Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Yu, Huajun; Huang, Yingbao; Chen, Lifang; Shi, Liuzhi; Yang, Yunjun; Xia, Weiliang

doi:10.2147/ijgm.s311118

Cited by 6 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding broadly supports the findings of other studies in this area that VAT is not significantly associated with the severity of AP 15,27 . CT imaging is a reliable method to analyze the fat distribution and measure adipose tissue, and according to some earlier findings, VAT was found to be an important indicator of AP severity 10,11 . A recent study by Ji Ting illustrated that for patients with HTGP, VAT and VAT/SAT were important factors to predict the severity of AP.…”

Section: Discussionsupporting

confidence: 86%

“…15,27 CT imaging is a reliable method to analyze the fat distribution and measure adipose tissue, and according to some earlier findings, VAT was found to be an important indicator of AP severity. 10,11 A recent study by Ji Ting illustrated that for patients with HTGP, VAT and VAT/SAT were important factors to predict the severity of AP. The different research results can be explained by several factors.…”

Section: Discussionmentioning

confidence: 99%

“…Recent trends in the severity of HTGP are also related to some radiological parameters that assess body composition parameters and have led to a proliferation of studies. 10,11 Body composition may change more significantly in patients with triglyceride-rich lipoproteins metabolism states or insulin resistance. 12 However, most of these studies did not consider changes in muscles or the association between them.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The modified computed tomography severity index combined with low skeletal muscle mass can better predict the severity of hypertriglyceridemia‐induced pancreatitis

Chen

et al. 2022

J Hepato Biliary Pancreat

Self Cite

View full text Add to dashboard Cite

Background: Body composition parameters are associated with hypertriglyceridemia-induced pancreatitis (HTGP). This study investigated the association between the quantity of muscle assessed using computed tomography (CT) and the severity of HTGP. Methods:The modified CT severity index (MCTSI) was calculated from admission examination data. Patients' characteristics and body composition parameters were collected. Univariate and multivariate logistic regression analyses were also performed. The receiver operating characteristic curves and corresponding area under the curves (AUC) were calculated to test the efficiency of the model. A nomogram was then constructed.Results: Of the 175 included patients, 138 were male, of which 85 had moderately severe to severe HTGP. Patients with low skeletal muscle mass (LSMM) and high MCTSI were significantly more likely to have moderately severe to severe HTGP. Patients with LSMM had lower body mass index, lower HDL-C level, higher amylase level, prevalence of surgery, shorter umbilical waist circumference, and longer length of hospital stay. Univariate and multivariate logistic regression analyses confirmed that female sex, lipase, total cholesterol, LSMM-MCTSI (P = .004, odds ratio = 23.105), and albumin were risk factors. The TOTAL model that combined LSMM-MCTSI and clinical risk parameters performed best (AUCs = 0.875), followed by other models (LSMM-MCTSI: AUCs = 0.762, MCTSI: AUCs = 0.728). The Delong test revealed significant difference. Finally, a nomogram was developed to predict the severity of HTGP. Conclusion:The performance of MCTSI in predicting severity can be improved by considering LSMM, which is a promising strategy for the treatment of HTGP.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The modified computed tomography severity index combined with low skeletal muscle mass can better predict the severity of hypertriglyceridemia‐induced pancreatitis

Chen

et al. 2022

J Hepato Biliary Pancreat

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several recent studies have shown that computed tomography (CT) defined muscle and adipose tissue features are associated with AP severity and mortality [17][18][19][20][21][22][23][24]. Since most patients undergo CT during the diagnosis of AP, predictions of prognosis of AP by simple body composition analyses using CT images is a cost-effective proposition.…”

Section: Introductionmentioning

confidence: 99%

“…Since most patients undergo CT during the diagnosis of AP, predictions of prognosis of AP by simple body composition analyses using CT images is a cost-effective proposition. Subcutaneous adipose tissue (SAT) are [18][19][20][21][22], visceral adipose tissue (VAT) area [17][18][19][20][21][22][23][24], skeletal muscle mass or density [17][18][19][20][21]24], visceral fat-to-muscle ratio (VMR) [21,22], and mean muscle attenuation (MMA) [19,21] have all been evaluated in the context of CT-defined body composition analysis. In addition, fatty liver has also been reported to affect AP severity [25].…”

Section: Introductionmentioning

confidence: 99%

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis

et al. 2021

View full text Add to dashboard Cite

Aim Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP). Methods Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The presence of liver cirrhosis was determined using clinical and CT findings. Factors potentially associated with moderately severe or severe AP were included in the multivariable logistic regression analysis. Results A total of 242 patients (47.0 ± 12.6 years, 215 males) with presumed AAP were included. The mild and moderately severe/severe (MSS) groups included 137 (56.6%) and 105 patients (43.4%), respectively. Patients in the MSS group had higher rates of liver cirrhosis, organ failure, and local complications. Among body composition parameters, mean MMA (33.4 vs 36.8 HU, P<0.0001) and abdominal muscle mass (126.5 vs 135.1 cm2, P = 0.029) were significantly lower in the MSS group. The presence of liver cirrhosis (OR, 4.192; 95% CI, 1.620–10.848) was found to be a significant risk factor for moderately severe or severe AP by multivariable analysis. Conclusion The results of this study suggest that liver cirrhosis has a significant impact on the severity of AAP. Of the body composition parameters examined, MMA and abdominal muscle mass showed potential as promising predictors.

show abstract

Relationship of computed tomography quantified visceral adiposity with the severity and complications of acute pancreatitis: a systematic review

Tan

Misur

et al. 2023

Jpn J Radiol

View full text Add to dashboard Cite

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Cited by 6 publications

References 49 publications

The modified computed tomography severity index combined with low skeletal muscle mass can better predict the severity of hypertriglyceridemia‐induced pancreatitis

The modified computed tomography severity index combined with low skeletal muscle mass can better predict the severity of hypertriglyceridemia‐induced pancreatitis

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis

Relationship of computed tomography quantified visceral adiposity with the severity and complications of acute pancreatitis: a systematic review

Contact Info

Product

Resources

About