Assessment of condylar anatomy and degenerative changes in temporomandibular joint disorders – A scoping review

Almpani, Konstantinia; Tran, Huy; Ferri, Anna; Hung, Man

doi:10.1016/j.jobcr.2023.10.004

Cited by 6 publications

(1 citation statement)

References 62 publications

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“…The etiologies of TMDs are multi-factorial and can be attributed to both physical and psychosocial factors. Various predisponding factors have been identified, including genetic, hormonal, functional, and anatomical factors [8,9].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Cervical Range of Motion in Subjects Affected by Temporomandibular Disorders: A Controlled Study

Nota,

Pittari,

Lannes

et al. 2023

Medicina

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Background and Objectives: The aim of this study were to compare the cervical ROM data obtained from accelerometer exams between patients suffering from TMDs (study group) and healthy patients (control group). Material and Methods: A sample of 43 young adult subjects (23 control subjects and 20 TMD patients) were included in this study and analyzed with the accelerometer (Baiobit™, BTS, Garbagnate Milanese, Milan, Italy) to assess cervical ROM using a standardized protocol, including the following occlusal conditions: mandibular rest position, clenching, clenching with cotton rolls, maximal intercuspation, and mandibular position with cotton rolls. The cervical ROM was measured in degrees and expressed as the mean and standard deviation. Results: TMD patients showed a reduced cervical extension compared to control subjects in all the conditions, with statistically significant relevance. Regarding the other movements, the differences were not statistically or clinically significant. Conclusions: Based on the results of the present study, it can be observed that temporomandibular disorders are associated with a decreased cervical extension range, while the remaining components of ROM do not seem to be significantly associated. The use of accelerometers in ROM analysis could be helpful in improving interdisciplinary communication between dentists and physiotherapists.

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Section: Introductionmentioning

confidence: 99%

Analysis of Cervical Range of Motion in Subjects Affected by Temporomandibular Disorders: A Controlled Study

Nota,

Pittari,

Lannes

et al. 2023

Medicina

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Evaluating the bi-directional causal association between temporomandibular disorders and neurodegenerative diseases: a two-sample Mendelian randomisation study

Huang,

Li,

Wang

et al. 2024

Preprint

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Background Previous observational studies suggested that temporomandibular disorders (TMD) are associated with neurodegenerative diseases (NDs). This association may be mediated by confounding factors or reverse causation. Therefore, the objective of this study was to test the causal relationship between TMD and the four most common NDs [Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS)]. Methods Data on TMD (N = 134,280), AD (N = 63,926), PD (N = 482,730), ALS (N = 80,610), and MS (N = 115,803) were extracted from publicly available Genome-Wide Association Studies (GWAS). Single-nucleotide polymorphisms (SNPs) used as instrumental variables (IVs) were screened by setting the association strength and eliminating linkage disequilibrium. Inverse-variance weighting (IVW) method was employed as the primary analytical approach. However, weighted median, Mendelian randomization-Egger, and simple and weighted modes were used as complementary analysis methods to evaluate the causal effects. Tests for heterogeneity and pleiotropy were also performed. The results' stability was assessed using a leave-one-out analysis. Results Our findings revealed significant positive genetic correlations between TMD and PD (odds ratio = 1.223, 95% confidence interval = 1.064–1.406, P = 0.005). There was no significant association between TMD and AD, ALS, or MS. In the reverse Mendelian randomisation, no significant results supported the effect of NDs on TMD (all P > 0.05). The analyses did not reveal any evidence of heterogeneity or horizontal pleiotropy. Conclusions These results supply evidence of a potential causal relationship between TMD and PD, emphasising the importance of effectively managing TMD to prevent PD. However, it is imperative to conduct comprehensive studies to validate and elucidate the underlying mechanisms of this association.

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Diet and risk of temporomandibular disorders: a Mendelian randomization study

Li,

Huang,

Wang

et al. 2024

Preprint

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Objectives Temporomandibular disorders (TMD) are the second most prevalent musculoskeletal condition after chronic low back pain, and have been demonstrated to be associated with a multiple factors. However, studies on the relationship between diet and TMD are limited. This study examined the causal association between diet and TMD using Mendelian randomization (MR) analysis. Materials and methods Leveraging large-scale genome-wide association study (GWAS) data, we employed MR analysis to assess the causal associations between diet and TMD. This study employed three primary methods: weighted median, MR-Egger, and inverse variance weighting (IVW). Furthermore, sensitivity analysis was performed to verify the results’ robustness. Results Our results suggested that a higher intake of tea, alcoholic drinks, and fizzy drinks correlated with an increased risk of TMD ( alcoholic drinks per week: odds ratio (OR) = 1.714; 95% confidence interval (CI), 1.056–2.782; P = 0.029; tea intake: OR = 1.476; 95% CI, 1.012–2.151; P = 0.043; fizzy drink intake: OR = 2.712; 95% CI, 1.504–4.890; P = 0.001). Sensitivity analysis revealed no evidence of heterogeneity or pleiotropy. However, no significant association was observed between TMD and other dietary intakes. Conclusions In this study, we presented convincing evidence supporting the presence of a causal link between diet and TMD. Refraining from excessive consumption of alcohol, tea, and fizzy beverages may contribute to TMD prevention. Clinical relevance Acknowledging the significance of diet as a controllable factor in preventing and managing TMD is crucial, and our research provides valuable perspectives on this matter.

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Assessment of condylar anatomy and degenerative changes in temporomandibular joint disorders – A scoping review

Cited by 6 publications

References 62 publications

Analysis of Cervical Range of Motion in Subjects Affected by Temporomandibular Disorders: A Controlled Study

Analysis of Cervical Range of Motion in Subjects Affected by Temporomandibular Disorders: A Controlled Study

Evaluating the bi-directional causal association between temporomandibular disorders and neurodegenerative diseases: a two-sample Mendelian randomisation study

Diet and risk of temporomandibular disorders: a Mendelian randomization study

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