Assessment of Corneal Biomechanical Properties in Normal Tension Glaucoma and Comparison With Open-angle Glaucoma, Ocular Hypertension, and Normal Eyes

Grise-Dulac, Alice; Saad, Alain; Abitbol, O.; Febbraro, Jean-Luc; Azan, Elodie; Moulin-Tyrode, Christine; Gatinel, Damien

doi:10.1097/ijg.0b013e318220daf0

Cited by 74 publications

(42 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][12][13][14][15][16][17][18][19][20][21][22] Central corneal thickness (CCT) has received the most attention in this regard, spurred by findings from the Ocular Hypertension Treatment Study (OHTS) in which CCT was the strongest independent predictor of conversion from ocular hypertension (OH) to primary open-angle glaucoma (POAG). 22 Furthermore, the OHTS investigators reported that after subjects were split into thin, intermediate, and thick CCT subgroups, subjects in the thinnest CCT subgroup were more than three times as likely to develop glaucoma compared with subjects in the thicker CCT subgroup.…”

Section: Introductionmentioning

confidence: 99%

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Pensyl

Sullivan-Mee

Torres-Monte

et al. 2012

Eye

View full text Add to dashboard Cite

Purpose To determine whether adjusting corneal hysteresis (CH) values for central corneal thickness (CCT) and intraocular pressure (IOP) improves its capability to differentiate primary open-angle glaucoma (POAG) from ocular hypertension (OH). Methods This prospective, observational, cross-sectional study included 169 eyes of 169 subjects with a diagnosis of POAG (n ¼ 81) or OH (n ¼ 88). We utilized the Ocular Response Analyzer (ORA), Pascal Dynamic Contour Tonometer (DCT), Goldmann applanation tonometer (GAT), and ORA ultrasound pachymeter to obtain CH, IOP, and CCT values. Correlational, regression, and t-test analyses were conducted before and after the sample was divided into low, intermediate, and thick CCT subgroups. Results In the full sample, CH and CCT were moderately correlated (r ¼ 0.44, Po0.001). Although both were related to diagnosis in univariate regression analysis, only CH was independently related to glaucoma diagnosis in multivariate analysis. After the sample was divided into CCT tertiles, CH was significantly lower in POAG vs OH eyes within all three CCT subgroups, and CH was the only multivariate variable that differentiated POAG from OH in each CCT subgroup. Moreover, the relationship between CH and diagnosis was more robust within the CCT subgroups compared with the full sample, suggesting that integrating CCT into CH interpretation is beneficial. Adjusting CH for IOP did not aid diagnostic precision in this study. ConclusionOur findings suggest that combining CH and CCT for glaucoma risk assessment improves diagnostic capability compared to using either factor alone. Conversely, adjusting CH for IOP provided no clear clinical benefit in this study.

show abstract

Section: Introductionmentioning

confidence: 99%

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Pensyl

Sullivan-Mee

Torres-Monte

et al. 2012

Eye

View full text Add to dashboard Cite

show abstract

“…4 The ORA provides the corneal hysteresis (CH) and the corneal resistance factor, which are considered to reflect the corneal biomechanical properties. 2 Studies have shown significant differences between the CH and corneal resistance factor values in normal eyes and those in eyes with glaucoma, [5][6][7] keratoconus, 4 high myopia, 8,9 and acquired pit of the optic nerve head 10 and eyes that have undergone refractive surgery. 11 Although these studies have suggested the relevance of corneal biomechanics in ocular clinical practice, studies also have reported the limitations of CH and corneal resistance factor as diagnostic tools.…”

mentioning

confidence: 99%

Factors Associated With Corneal Deformation Responses Measured With a Dynamic Scheimpflug Analyzer

Miki

Maeda

Ikuno

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to clarify correlations between corneal deformation parameters measured with a dynamic Scheimpflug analyzer and baseline factors such as axial length, intraocular pressure (IOP), age, central corneal thickness (CCT), and corneal curvature.METHODS. Ninety-six eyes of 96 healthy subjects (mean 55.2 6 16.1 years of age) were examined using a dynamic Scheimpflug analyzer. Eighteen of 35 deformation parameters were selected for analyses based on measurement reliability and clinical relevance. The associations between corneal deformation parameters and axial length, IOP, age, CCT, and average corneal power were evaluated using multivariate regression analyses.RESULTS. Deformation parameters were correlated significantly with axial length (n ¼ 13), IOP (n ¼ 13), age (n ¼ 8), and CCT (n ¼ 6) in the multivariate models. Longer axial length corresponded with greater corneal deformability, less viscous damping, and less movement of the entire eye. Higher IOP was associated with greater corneal resistance and less movement of the entire eye. Older age was associated with less corneal deformability and greater movement of the entire eye. Corneal curvature was correlated significantly with only three deformation parameters.CONCLUSIONS. This study clarified the substantial impact of axial length, age, and IOP on the biomechanical responses of the cornea and the entire eye. In contrast, corneal curvature did not affect most of the deformation parameters. The current results confirmed the importance of corneal biomechanics, especially in eyes with longer axial length and in older subjects.

show abstract

“…The ORA-based corneal biomechanical parameters, although significantly lower in glaucoma eyes (including PACG) compared to normals, [4][5][6]8 do not appear to be related to disease severity within PACG subjects. Our findings of the significant associations between CH and CRF with CCT are comparable with the findings in eyes with POAG.…”

Section: Discussionmentioning

confidence: 99%

“…3 Several studies have reported that CH is lower in eyes with glaucoma compared to normals. [4][5][6] Within the open angle subtypes, CH is reported to be lower in primary open angle glaucoma (POAG) compared to those with ocular hypertension (OHT) or glaucoma suspect. [5][6][7] However, within POAG itself, reports about CH differences between normal tension glaucoma (NTG) and high-tension glaucoma (HTG) have been variable.…”

mentioning

confidence: 99%

“…[4][5][6] Within the open angle subtypes, CH is reported to be lower in primary open angle glaucoma (POAG) compared to those with ocular hypertension (OHT) or glaucoma suspect. [5][6][7] However, within POAG itself, reports about CH differences between normal tension glaucoma (NTG) and high-tension glaucoma (HTG) have been variable. While Ang et al 8 found higher CH among NTG, Shah et al 4 reported lower CH when compared to HTG.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma

Nongpiur

Png

Chiew

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Nongpiur ME, Png O, Chiew JW, et al. Lack of association between corneal hysteresis and corneal resistance factor with glaucoma severity in primary angle closure glaucoma. Invest Ophthalmol Vis Sci. 2015;56:6879-6885. DOI:10.1167/ iovs.15-17930 PURPOSE. We investigated the association between corneal hysteresis (CH) and corneal resistance factor (CRF) with glaucoma severity in primary angle closure glaucoma (PACG). METHODS.We recruited 204 subjects with PACG. Each subject underwent CH and CRF measurements using the Ocular Response Analyzer (ORA), optic nerve head topography measurement using scanning laser ophthalmoscopy, and visual field assessment. Glaucoma severity was based on the visual field mean deviation (MD) and classified as mild (71), moderate (55), and severe (78).RESULTS. The mean age 6 SD of study subjects was 68.7 6 8.9 years, with most being Chinese (n ¼ 186; 91.2%). Corneal hysteresis and CRF were lowest in the severe PACG group (9.32 6 1.86 and 9.50 6 1.67 mm Hg) followed by moderate PACG (9.38 6 1.88 and 9.73 6 1.88 mm Hg) and mild PACG (9.47 6 1.90 and 9.85 6 1.75 mm Hg) respectively, but the differences were not significant (P ¼ 0.89 and P ¼ 0.46, respectively). There was a significant positive correlation between CH and central corneal thickness (CCT; correlation coefficient [r] ¼ 0.26, P < 0.001), CRF and CCT (r ¼ 0.43, P < 0.001), and negative correlation between CRF and vertical cup-disc ratio (VCDR; r ¼ À0.20, P ¼ 0.004), and CRF with cup-disc area (r ¼ À0.14, P ¼ 0.04). Corneal hysteresis and CRF were not correlated with MD (r ¼ 0.01 for CH, r ¼ 0.1 for CRF). After multivariate analyses, adjusting for age, sex, CCT, axial length, intraocular pressure, and number of glaucoma medication, no significant associations were noted between CH and CRF with MD, VCDR, disc area, rim area, or cup area.CONCLUSIONS. Corneal biomechanical parameters measured by the ORA are not associated with severity of glaucoma in PACG.

show abstract

Assessment of Corneal Biomechanical Properties in Normal Tension Glaucoma and Comparison With Open-angle Glaucoma, Ocular Hypertension, and Normal Eyes

Abstract: NTG was associated with significantly lower CRF than chronic POAG and N patients. CH and CRF could be a useful tool in early diagnosis of NTG.

Cited by 74 publications

References 19 publications

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

Factors Associated With Corneal Deformation Responses Measured With a Dynamic Scheimpflug Analyzer

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma

Contact Info

Product

Resources

About