Assessment of coronary vasodilator reserve by N-13 ammonia PET using the microsphere method and Patlak plot analysis

Tadamura, Eiji; Tamaki, Nagara; Yonekura, Yoshiharu; Kudoh, Takashi; Magata, Yasuhiro; Torizuka, Tatsuo; Tateno, Madoka; Nohara, Ryuji; Sasayama, Shígetake; Konishi, Junji

doi:10.1007/bf03165036

Cited by 9 publications

(2 citation statements)

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“…[11][12][13][14][15] Nor was the recovery of CFR in the septal and inferior walls on dipyridamole provocation after EECP treatment enough compared with previous studies. 9,[11][12][13][14][15] We hypothesized that the decrease in the CFR at anterior and lateral walls was because the coronary perfusion at baseline after treatment increased compared with that done before treatment, and the blood steal from the anterior and lateral walls to the inferior wall might have been augmented with the developed collateral vessels. However, CAG was not performed after treatment, and so this hypothesis has not been proved yet.…”

Section: Discussionmentioning

confidence: 99%

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Improvement of Regional Myocardial and Coronary Blood Flow Reserve in a Patient Treated With Enhanced External Counterpulsation

et al. 1999

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Section: Discussionmentioning

confidence: 99%

“…The coronary perfusions were calculated with the ROIs following Tadamura's method. 9 The CFR was calculated as that the coronary perfusion during provocation was divided by that on the baseline.…”

Section: Interpretation Of Imagesmentioning

confidence: 99%

Improvement of Regional Myocardial and Coronary Blood Flow Reserve in a Patient Treated With Enhanced External Counterpulsation

et al. 1999

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Evaluation of coronary blood flow reserve by13N-NH3 positron emission computed tomography (PET) with dipyridamole in the treatment of hypertension with the ACE inhibitor (Cilazapril)

et al. 2000

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These results indicate that hypertensive patients at the early stage show decreased coronary flow reserve despite having normal resting flow. Treatment with an ACE inhibitor (Cilazapril) for 12 weeks improved coronary flow reserve in 42% of our patients. The CVR of the patients with CFR < 2.0 showed improvement compared to those with CFR> or = 2.0. This result indicates that an ACE inhibitor (e.g., Cilazapril) should be one of the choices for improving CFR if hypertensive patients in early stage show signs of ischemia or diastolic dysfunction, which may be one of the sequels of reserve restriction.

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Myocardial viability assessment using nuclear imaging

Matsunari¹,

Taki

Nakajima

et al. 2003

Ann Nucl Med

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Myocardial assessment continues to be an issue in patients with coronary artery disease and left ventricular dysfunction. Nuclear imaging has long played an important role in this field. In particular, PET imaging using 18F-fluorodeoxyglucose is regarded as the metabolic gold standard of tissue viability, which has been supported by a wide clinical experience. Viability assessment using SPECT techniques has gained more wide-spread clinical acceptance than PET, because it is more widely available at lower cost. Moreover, technical advances in SPECT technology such as gated-SPECT further improve the diagnostic accuracy of the test. However, other imaging techniques such as dobutamine echocardiography have recently emerged as competitors to nuclear imaging. It is also important to note that they sometimes may work in a complementary fashion to nuclear imaging, indicating that an appropriate use of these techniques may significantly improve their overall accuracy. In keeping these circumstances in mind, further efforts are necessary to further improve the diagnostic performance of nuclear imaging as a reliable viability test.

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Assessment of coronary vasodilator reserve by N-13 ammonia PET using the microsphere method and Patlak plot analysis

Abstract: The modified microsphere method is a very simple and reliable approach for quantifying MBF with N-13 ammonia PET which is comparable to Patlak graphical analysis. It also makes possible CVR assessment as accurate as Patlak graphical analysis.

Cited by 9 publications

References 15 publications

Improvement of Regional Myocardial and Coronary Blood Flow Reserve in a Patient Treated With Enhanced External Counterpulsation

Improvement of Regional Myocardial and Coronary Blood Flow Reserve in a Patient Treated With Enhanced External Counterpulsation

Evaluation of coronary blood flow reserve by13N-NH3 positron emission computed tomography (PET) with dipyridamole in the treatment of hypertension with the ACE inhibitor (Cilazapril)

Myocardial viability assessment using nuclear imaging

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