Assessment of Cortical Dysfunction in Infantile Esotropia Using fMRI

Yang, Xubo; Zhang, Junran; Lang, Lijuan; Gong, Qiyong; Liu, Longqian

doi:10.5301/ejo.5000368

Cited by 30 publications

(39 citation statements)

References 41 publications

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“…The precuneus is not only involved in the interwoven network of the self-consciousness ( 30 ), but also involved in different aspects of visuospatial mental operations ( 31 ). A previous study suggested that the bold signal was increased in the left cingulate gyrus, bilateral precuneus and left angular gyrus in the patients with infantile esotropia ( 32 ). In the present study, significantly decreased GMV values were observed in the brain regions of the left cuneus in CS patients.…”

Section: Discussionmentioning

confidence: 94%

The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

Ouyang

Yang

Huang

et al. 2017

Molecular Medicine Reports

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To compare the difference in white matter volume (WMV) and gray matter volume (GMV) between the comitant strabismus (CS) patients and health controls by voxel-based morphometry (VBM) and the relationship with behavioral performance. A total of 20 patients with comitant strabismus (10 males and 10 females), and 20 healthy subjects (10 males and 10 females) with matched age, sex status underwent magnetic resonance examination. The authors analyzed the original 3D T1 brain images using the VBM module. The comitant strabismus groups were compared with the control groups for the GMW and WMV of the entire brain. Correlation analysis was performed to investigate the relationship between the GMV and WMV altered areas and the behavioral performance in comitant strabismus. CS patients were distinguishable from the healthy controls (HCs) by receiver operating characteristic curves. Results of the VBM analysis demonstrated that the CS groups had decreased GMV in the brain regions of the left middle temporal pole, left cerebellum posterior lobe, right posterior cingulate cortex, left cuneus and right premotor cortex. Meanwhile, the WMV was significantly decreased in the brain regions of the left middle temporal gyrus, right middle temporal gyrus, left middle temporal gyrus, right precuneus and right premotor cortex in the comitant strabismus patients compared with HCs. Furthermore, the duration of CS was negatively correlated with the GMV values of the left middle temporal pole (r=−0.486, P=0.030). CS caused GMV and WMV atrophy in many brain regions, which may indicate the neural mechanisms of the ocular motility disorders in CS patients.

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Section: Discussionmentioning

confidence: 94%

The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

Ouyang

Yang

Huang

et al. 2017

Molecular Medicine Reports

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“… 39 , 40 Researches of strabismus subjects suggested that white matter volume was reduced in the right precuneus in the comitant strabismus patients. 41 Nevertheless, Yang et al found a significant increase of the bold signal in the bilateral precuneus in the patients with infantile esotropia, 42 and cortical activations in intermittent exotropia were found in right precuneus. 23 In the present study, we detected an increased ALFF in the right precuneus of SA group.…”

Section: Discussionmentioning

confidence: 98%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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ObjectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects.Patients and methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson’s correlation analysis.ResultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.ConclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.

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“… 41 The parietal and occipital lobes were involved in gaze, movement, and body guidance. 42 Yang et al 43 showed that the left cingulate gyrus, bilateral precuneus, and left angular gyrus visual cortex may compensate for fusion dysfunction in infantile esotropia. In our study, we found higher ALFF values in the left angular gyrus, which may reflect a compensation for visual fusion dysfunction in patients with strabismus.…”

Section: Discussionmentioning

confidence: 99%

A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation

Tan¹,

Huang²,

Zhang³

et al. 2016

NDT

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ObjectiveThe aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to investigate local features of spontaneous brain activity in patients with congenital comitant strabismus and clarify their relationship with emotional and psychosocial problems.MethodsA total of 20 patients with congenital comitant strabismus (ten males and ten females), and 20 healthy controls (ten males and ten females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. Congenital comitant strabismus patients were distinguished from healthy controls by receiver operating characteristic curve. Correlation analysis was performed to explore the relationships between the observed mean ALFF signal values of the different areas and the Chinese version of the Hospital Anxiety and Depression Scale.ResultsCompared with healthy controls, patients with congenital comitant strabismus had significantly lower ALFF in the bilateral medialfrontal gyrus and higher values in the bilateral cerebellum posterior lobe and left angular gyrus. In the congenital comitant strabismus group, the Hospital Anxiety and Depression Scale-depression score showed a negative correlation with the ALFF signal values of the bilateral medial frontal gyrus (r=−0.550, P=0.012) and a negative correlation was noted between the mean ALFF signal values of the left angular gyrus and strabismus duration (r=−0.515, P=0.020).ConclusionCongenital comitant strabismus mainly involves dysfunction in the bilateral medial frontal gyrus, bilateral cerebellum posterior lobe, and left angular gyrus, which may reflect the underlying pathologic mechanism of congenital strabismus.

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Assessment of Cortical Dysfunction in Infantile Esotropia Using fMRI

Cited by 30 publications

References 41 publications

The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation

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