A multi-axial continuum damage mechanics (CDM) model was proposed to calculate the multi-axial creep-fatigue damage o f a high temperature component. A specific outer cyl inder o f a 1000M W supercritical steam turbine was used in this study, and the interac tion o f the creep and fatigue behavior o f the outer cylinder was numerically investigated under a startup-running-shutdown process. To this end, the multi-axial stress-strain behavior o f the outer cylinder was numerically studied using A baqus. The in-site meas ured temperatures were provided to validate the heat transfer coefficients, which were used to calculate the temperature field o f the outer cylinder. The multi-axial mechanics behavior o f the outer cylinder was investigated in detail, with regard to the temperature, Mises stress, hydrostatic stress, multi-axial toughness factor, multi-axial creep strain, and damage. The results demonstrated that multi-axial mechanics behavior reduced the total damage.