Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single‐blinded, placebo‐controlled, right‐left comparative clinical study

El-Komy, Mohamed H.M.; Shalaby, Suzan; Hegazy, Rehab A.; Hay, Rania Abdel; Sherif, Saly; Bendas, Ehab R.

doi:10.1111/jocd.12298

“…The balneological procedures with the use of sulfide/hydrogen sulfide mineral waters are commonly used in the treatment of a variety of dermatological diseases, including psoriasis, atopic dermatitis, dermatoses with congenital hyperkeratosis and even scleroderma [ 37 ]. On the other hand, recent observations documented a beneficial effect of many formulations containing LA on the skin [ 38 ]. The comparison of the effects of LA and H 2 S/sulfane sulfur on the skin showed striking analogies.…”

Section: Discussionmentioning

confidence: 99%

Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Bilska‐Wilkosz

¹

,

Iciek

²

,

Kowalczyk-Pachel

³

et al. 2017

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The aim of the present study was to verify whether lipoic acid (LA) itself is a source of H2S and sulfane sulfur. It was investigated in vitro non-enzymatically and enzymatically (in the presence of rat tissue homogenate). The results indicate that both H2S and sulfane sulfur are formed from LA non-enzymatically in the presence of environmental light. These results suggest that H2S is the first product of non-enzymatic light-dependent decomposition of LA that is, probably, next oxidized to sulfane sulfur-containing compound(s). The study performed in the presence of rat liver and kidney homogenate revealed an increase of H2S level in samples containing LA and its reduced form dihydrolipoic acid (DHLA). It was accompanied by a decrease in sulfane sulfur level. It seems that, in these conditions, DHLA acts as a reducing agent that releases H2S from an endogenous pool of sulfane sulfur compounds present in tissues. Simultaneously, it means that exogenous LA cannot be a direct donor of H2S/sulfane sulfur in animal tissues. The present study is an initial approach to the question whether LA itself is a donor of H2S/sulfane sulfur.

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“…There were no instances of irritation, peeling or other apparent adverse side effects [152]. In a similar study with 5% Cubosomal ALA significantly increased epidermal thickness with effective and safe modality for improving aging face [154]. Lin et.al, 2004 were unable to detect protection using ALA alone or together with vitamins C and E. According to them, a commercial formulation of ALA provided no protection [153].…”

Section: G α-Lipoic Acidmentioning

confidence: 97%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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“…There were no instances of irritation, peeling or other apparent adverse side effects [152]. In a similar study with 5% Cubosomal ALA significantly increased epidermal thickness with effective and safe modality for improving aging face [154]. Were unable to detect protection using ALA alone or together with vitamins C and E. According to them, a commercial formulation of ALA provided no protection [153].…”

Section: G α-Lipoic Acidmentioning

confidence: 99%

Skin Aging and Modern Age Anti-Aging Strategies

AK¹

2019

Austin J Womens Health

0

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, "photoaging" is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue. Upon exposure to a strain, such a multilayer system demonstrates structural instabilities in its stiffer layers, which in its simplest form is the wrinkling. These instabilities appear hierarchically when the mechanical strain in the skin exceeds some critical values. Their appearance is mainly dependent on the mismatch in mechanical properties between adjacent skin layers or between the skin and subcutaneous white adipose tissue, on the adhesive strength and thickness ratios between the layers, on their bending and tensile stiffness as well as on the value of the stress existing in single layers. Gradual reduction of elastic fibers in aging significantly reduces the skin's ability to bend, prompting an up to 4-fold reduction of its stability against wrinkling, thereby explaining the role of these fibers in skin aging. Anti-aging medicine is practiced by physicians, scientists, and researchers dedicated to the belief that the process of physical aging in humans can be slowed, stopped, or even reversed through existing medical and scientific interventions. This specialty of medicine is based on the very early detection and prevention of age-related diseases. Physicians practicing anti-aging medicine seek to enhance the quality of life as well as its length, limiting the period of illness and disability toward the end of one's life. Anti-aging medicine encompasses lifestyle changes (diet and exercise); hormone replacement therapies, as needed, determined by a physician through blood testing (DHEA, melatonin, thyroid, human growth hormone, estrogen, testosterone); antioxidants and vitamin supplements;...

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Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single‐blinded, placebo‐controlled, right‐left comparative clinical study

Abstract: 5% Cubosomal ALA is an effective and safe modality for improving aging face.

Cited by 18 publications

References 16 publications

Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Skin Aging & Modern Age Anti-aging Strategies

Skin Aging and Modern Age Anti-Aging Strategies

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