Assessment of Cytotoxic and Immunomodulatory Properties of Piper Nigrum Linn. (White Pepper) Seed Extract

Saravanan, P; Mohamed, M Sheik Noor; K, Jaikumar; Anand, D.

doi:10.25004/ijpsdr.2017.090204

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only WE of T. cordifolia exhibited a dose-dependent pinocytic activity and modulated the immune system; its water extract is superior to alcoholic extract [30]; however WE of P. emblica and P. nigrum showed maximum pinocytic activity at lowest dose. P. nigrum showed immunomodulatory potential through macrophage proliferation as well as splenocyte proliferation [31]. W. somnifera did not show any significant differences among three different extracts.…”

Section: Discussionmentioning

confidence: 79%

TLC-Based Metabolite Profiling and Bioactivity-Based Scientific Validation for Use of Water Extracts in AYUSH Formulations

Zahiruddin

Parveen

Khan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

We aimed to develop a chromatographic method for scientific validation of water extract of some important Indian traditional plants used in AYUSH-based formulation as immunomodulator and to evaluate their bioactive potential. Fruits of Phyllanthus emblica L. and Piper nigrum L., stem of Tinospora cordifolia (Willd.) Miers, rhizome of Curcuma longa L., leaves of Ocimum sanctum L. and Achillea millefolium L., roots of Withania somnifera L., and stem bark of Azadirachta indica A. Juss. were coarsely powdered and extracted in three different solvents (water, ethanol, and hydroethanol). The antioxidant potential was determined through 1, 1-diphenyl-2-picrylhydrazyl and ferric reducing capacity methods. Thin-layer chromatography (TLC) was carried out for the comparative metabolite profiling of the extracts using toluene, ethyl acetate, and formic acid (5 : 4 : 1, v/v/v) as a solvent system. In vitro immunomodulatory activity of the extracts has been tested on splenocyte proliferation and pinocytic assay. Hydroethanolic extract (HEE) of most of the plant materials has the highest phenolic and flavonoid contents, followed by water extract (WE) and ethanolic extract (EE), whereas the water extracts of most of the plant material showed better antioxidant activity. Almost all extract exhibited splenocyte proliferation and pinocytic activity in a dose-dependent manner. But water extract showed significantly higher splenocyte proliferation and pinocytic activity as compared to the other two extracts. TLC analysis resulted in detection of totally 63 and 56 metabolites at 254 nm and 366 nm, respectively. Through principal component analysis (PCA), it was observed that metabolite pattern of different extracts from same plant materials may be different or similar. This preliminary result can be used for quality evaluation and to develop a synergy-based polyherbal combination of water extracts of selected plant materials.

show abstract

Section: Discussionmentioning

confidence: 79%

TLC-Based Metabolite Profiling and Bioactivity-Based Scientific Validation for Use of Water Extracts in AYUSH Formulations

Zahiruddin

Parveen

Khan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

Traditional Formulations for Managing COVID-19: A Systematic Review

Bhandari,

Balkrishna,

Maheshkumar

et al. 2024

Journal of Integrative and Complementary Medicine

View full text Add to dashboard Cite

Unravelling the Immune Modulatory Effect of Indian Spices to Impede the Transmission of COVID-19: A Promising Approach

Devan

Nair

Kumar

et al. 2022

CPB

View full text Add to dashboard Cite

: Months after WHO declared COVID-19 as a Global Public Health Emergency of International Concern, it does not seem to be flattening the curve as we are still devoid of an effective vaccine and treatment modality. Amid such uncertainty, being immune is the best strategy to defend against corona attack. As the whole world is referring back to immune-boosting grandma remedies, interest is rekindled in the Indian system of Medicine, which is gifted with an abundance of herbal medicines as well as remedies. Among them, spices (root, rhizome, seed, fruit, leaf, bud, and flower of various plants used to add taste and flavors to food) are bestowed with immense medicinal potential. A plethora of clinical as well as preclinical studies reported the effectiveness of various spices for various ailments. The potential immune-boosting properties together with its excellent safety profile are making spices the current choice of Phyto-research as well as the immune-boosting home remedies during these sceptical times. The present review critically evaluates the immune impact of various Indian spices and their potential to tackle the novel coronavirus, with comments on the safety and toxicity aspects of spices.

show abstract

Assessment of Cytotoxic and Immunomodulatory Properties of Piper Nigrum Linn. (White Pepper) Seed Extract

Cited by 4 publications

References 0 publications

TLC-Based Metabolite Profiling and Bioactivity-Based Scientific Validation for Use of Water Extracts in AYUSH Formulations

TLC-Based Metabolite Profiling and Bioactivity-Based Scientific Validation for Use of Water Extracts in AYUSH Formulations

Traditional Formulations for Managing COVID-19: A Systematic Review

Unravelling the Immune Modulatory Effect of Indian Spices to Impede the Transmission of COVID-19: A Promising Approach

Contact Info

Product

Resources

About