Assessment of depression and anxiety in patients with chronic liver disease

Popović, Dušan; Culafic, Djordje; Kisić-Tepavčević, Darija; Kovačević, Nada; Špuran, Milan; Djuranović, Srdjan; Jovicic, Ivana; Krstić, Miodrag; Perišić, Mirjana; Gazibara, Tatjana

doi:10.2298/vsp130904007p

Cited by 19 publications

(24 citation statements)

References 45 publications

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“…A total of 39 studies assessing symptom prevalence were included (see Supplementary Material). 20–58 The majority reported data from North America (16) and Europe (14), although Asia (8) and Africa (1) were also covered. Most were cross-sectional studies conducted while patients were outpatients or stable after hospitalization.…”

Section: Symptom Prevalence Of Patients With End-stage Liver Diseasementioning

confidence: 99%

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

et al. 2018

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Background:End-stage liver disease is a common cause of morbidity and mortality worldwide, yet little is known about its symptomatology and impact on health-related quality of life.Aim:To describe symptom prevalence and health-related quality of life of patients with end-stage liver disease to improve care.Design:Systematic review.Data sources:We searched eight electronic databases from January 1980 to June 2018 for studies investigating symptom prevalence or health-related quality of life of adult patients with end-stage liver disease. No language restrictions were applied. Meta-analyses were performed where appropriate.Results:We included 80 studies: 35 assessing symptom prevalence, 41 assessing health-related quality of life, and 4 both. The instruments assessing symptoms varied across studies. The most frequently reported symptoms were as follows: pain (prevalence range 30%–79%), breathlessness (20%–88%), muscle cramps (56%–68%), sleep disturbance (insomnia 26%–77%, daytime sleepiness 29.5%–71%), and psychological symptoms (depression 4.5%–64%, anxiety 14%–45%). Erectile dysfunction was prevalent (53%–93%) in men. The health-related quality of life of patients with end-stage liver disease was significantly impaired when compared to healthy controls or patients with chronic liver disease. Compared with compensated cirrhosis, decompensation led to significant worsening of both components of the 36-Item Short Form Survey although to a larger degree for the Physical Component Summary score (decrease from average 6.4 (95% confidence interval: 4.0–8.8); p < 0.001) than for the Mental Component Summary score (4.5 (95% confidence interval: 2.4–6.6); p < 0.001).Conclusion:The symptom prevalence of patients with end-stage liver disease resembled that of patients with other advanced conditions. Given the diversity of symptoms and significantly impaired health-related quality of life, multidisciplinary approach and timely intervention are crucial.

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Section: Symptom Prevalence Of Patients With End-stage Liver Diseasementioning

confidence: 99%

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

et al. 2018

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“…The sampling method and detailed methodology were published previously 30,32 . We performed a cross-sectional study for a period of one year (October 2009 -October 2010).…”

Section: Patientsmentioning

confidence: 99%

“…The study was conducted at the Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, and included 103 patients with chronic liver disease (chronic hepatitis or cirrhosis). Exclusion criteria were: age < 18 years, psychiatric disorders, acute complications of the CLD, hepatic encephalopathy (grade > 2) and liver transplantation 30,32 .…”

Section: Patientsmentioning

confidence: 99%

“…Although the numerous and heterogeneous studies were conducted in order to find out the influence of the CLD on HRQoL, the majority of these investigations were based on the importance of etiology 1,6,14,15,[17][18][19][20][21][22][23] and severity of the CLD 1, 2, 6, 14-16, 19, 20-22, 24-26 on HRQoL. The most often evaluated predictors of HRQoL among cohort of the CLD patients were: gender 6, 12, 14-16, 19-23, 27 , age 6, 14, 16, 19-23, 27, 28 , ascites 15,23 , hepatic encephalopathy 8,23 , depression and anxiety 16,18,21,26,[28][29][30] and fatigue 12,18,[26][27][28] . Furthermore, the possible influence of level of education, employment and marital status on HR-QoL is available from studies conducted on patients with liver transplantation 31 and patients with the CLD using the disease specific questionnaire 16,19 .…”

Section: Introductionmentioning

confidence: 99%

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Quality of life in patients with chronic liver disease

Popović¹,

Kisić-Tepavčević²,

Kovačević³

et al. 2018

VOJNOSANIT PREGL

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Background/Aim. Quality of life is impaired in patients with the chronic liver disease (CLD). Patients with this disease have numerous disabling problems which lead to a reduced health related quality of life (HRQoL). The aim of our study was to evaluate the predictive value of selected socio-demographic and clinical characteristics on HRQoL in Serbian cohort of patients with the CLD. Methods. Over a period of one year, we performed a study which included patients with the CLD. We used Short Form Health Survay-36 (SF-36) for assessment of HRQoL. The assessment of depression and anxiety was made by using Hamilton scale of depression and anxiety, while the assessment of fatigue was performed by Fatigue severity scale. Results. The study included 103 patients with the CLD. The average values of the overall SF-36 scores were 52.6 ± 20.4, while the mean score of the composite scores were 53.5 ± 19.6 for the Mental component summary and 49.8 ± 21.3 for the Physical component summary. Some domains of HRQoL were significantly affected by following factors: gender, age, employment status, alcohol consumption, depression, anxiety and fatigue. Predictors of physical components of HRQoL were employment, depression and fatigue, and predictors of mental components were depression and fatigue. Conclusion. The tested socio-demographic, clinical and behavioral factors have an impact on the HRQoL in patients with the CLD. The most important predictors of HRQoL are behavioral factors suggesting the need for an adequate therapeutic action in order to improve the HRQoL in these patients.

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“…For example, Ismail et al (2007) used standard psychiatric interview (Schedules of Clinical Assessment in Neuropsychiatry) to diagnose MDD in patients with diabetes and their first foot ulcer. In a cross-sectional study, Popović et al (2015) used the Hamilton depression rating scale (HDRS) in patients with CLD and found that depression was present in 62.9% of them. In addition, a number of studies on CLD have instead used self-report questionnaires (Bellentani et al, 1994; Dwight et al, 2000; Dan et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

Huang

Liu

2017

Front. Mol. Neurosci.

102

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The occurrence of depression is higher in patients with chronic liver disease (CLD) than that in the general population. The mechanism described in previous studies mainly focused on inflammation and stress, which not only exists in CLD, but also emerges in common chronic diseases, leaving the specific mechanism unknown. This review was to summarize the prevalence and risk factors of depression in CLD including chronic hepatitis B, chronic hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease, and to point out the possible underlying mechanism of this potential link. Clarifying the origins of this common comorbidity (depression and CLD) may provide more information to understand both diseases.

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Assessment of depression and anxiety in patients with chronic liver disease

Abstract: Age and the mean corpuscular volume have significant influence on the HDRS score while unemployment, gastrointestinal bleeding, serum potassium and serum sodium have predictive value for HARS score.

Cited by 19 publications

References 45 publications

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

Quality of life in patients with chronic liver disease

Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

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