Assessment of depression in children and adolescents with sickle cell anemia in a low-resource setting: a comparative study

Ezenwosu, Osita U; Chukwu, BF; Uwaezuoke, Ndubuisi A; Ezenwosu, Ifeyinwa L; Urom, Kelechi O; Udorah, Maria; Ikefuna, AN; Emodi, IJ

doi:10.1080/08880018.2022.2071510

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Several studies have investigated the association between anemia and depression among specific populations, such as women, 19 , 20 elderly individuals, 21 cancer patients, 22 children and adolescents, 23 and healthy adults. 24 However, research on the association between anemia and depression among men is scarce, and some studies have reported controversial outcomes in this regard.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Anemia and Depressive Symptoms in Non-White Male Adults: National Health and Nutrition Examination Survey (2005–2018)

Mou,

Zhou,

Feng

2023

J Res Health Sci

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Background: The relationship between anemia and depression remains controversial. This study aimed to investigate the association between hemoglobin (Hb) levels and depressive symptoms. Study Design: A cross-sectional study. Methods: This study was conducted using National Health and Nutrition Examination Survey data from 2005–2018. Hb levels were obtained from laboratory files, and depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9). Multivariable logistic regression analysis and smoothing plots were performed to examine the relationship between anemia and depression, including potential nonlinear associations. Results: The study included 6008 male adults. Multivariable analysis revealed that anemia was associated with an increased odds ratio for mild (OR=1.49, 95% CI: 1.06, 2.10) and moderate (OR=2.05, 95% CI: 1.14-3.70) anemia. Additionally, each additional g/dL of Hb was significantly inversely associated with developing depression (OR=0.91, 95% CI: 0.85, 0.96). A nonlinear relationship was detected between Hb and depression, with an inflection point at 15 g/dL. Below this threshold, there was a significantly negative association between Hb and depression (OR=0.88, 95% CI: 0.79, 0.98); no significant relationship was observed above it (OR=1.05, 95% CI: 0.84, 1.31). Conclusion: Anemia was positively associated with depression in non-White American men. A nonlinear relationship between Hb and depression was detected, and it had a saturation effect. A significant negative correlation with depression was observed when the Hb level was below 15 g/dL.

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Section: Introductionmentioning

confidence: 99%

The Association Between Anemia and Depressive Symptoms in Non-White Male Adults: National Health and Nutrition Examination Survey (2005–2018)

Mou,

Zhou,

Feng

2023

J Res Health Sci

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Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

Elenga,

Lony,

Mafemamissindu

et al. 2024

Depression and Anxiety

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Importance: While the prevalence and impact of depression have been widely described in sickle cell disease, its relationship with precariousness has never been studied.Objective: This study aimed to describe the prevalence of depression and its relationship with clinical and demographic factors including social precariousness in children with sickle cell disease in French Guiana.Methods: We included children aged 12–18 years with sickle cell disease from the Sickle Cell Reference Center in French Guiana. A simple depression questionnaire “Child depression inventory 2” was proposed and completed by a clinical examination and consultation by a psychologist. Using the known assessment of health inequalities and poverty in health screening centres (EPICES) score, we developed a composite precariousness score that uses five items (each item is scored from 0 to 2). According to the chosen items, precariousness was defined as a score ≥5.Results: The prevalence of depression was 42.5% [95% CI: 31.5–54]. The median age was 15 years [95% CI: 13–17]. The age distribution peaked at 14 years in patients with depression. There were 76% of precarious patients in the depressed group and 18% in the control group (p < 0.0001). In multivariate analysis, genotype SC (OR = 7.66, [1.17; 50.13], p = 0.0338) and precariousness (OR = 15.68, [4.73; 51.94], p < 0.0001) were associated with higher rates of depression. Baseline hemoglobin levels (OR = 0.48, [0.27; 0.88], p = 0.0173) were also associated with lower rates of depression.Conclusions and Relevance: Despite free healthcare, precariousness is an independent risk factor for depression.

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Interacción Entre la Depresión y la Nutrición en Adolescentes: Explorando el Vínculo con la Anemia

Gordillo Montero

2024

Revista Científica y Académica

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El vínculo entre la depresión y los hábitos alimenticios en jóvenes es fundamental en salud pública y psicología clínica. Numerosos estudios investigan esta conexión compleja, revelando hallazgos diversos y resaltando la importancia de considerar ambos aspectos para fomentar el bienestar general de los adolescentes. Se realizó una revisión sistemática para explorar el vínculo entre depresión y alimentación en esta población, enfocándose en su relación con la anemia. Se recopilaron datos de estudios indexados de los últimos cinco años, priorizando la mejor evidencia disponible sobre depresión y anemia. La revisión abarcó búsqueda, evaluación, síntesis y análisis de los estudios relevantes. Los resultados evidencian que dietas desequilibradas pueden incrementar la predisposición a sufrir alteraciones en el estado de ánimo, y la depresión puede influenciar las preferencias alimenticias y la cantidad consumida. Fomentar una alimentación saludable y apoyar la salud mental son esenciales para abordar integralmente la depresión y mejorar el bienestar emocional y físico de los adolescentes.

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Assessment of depression in children and adolescents with sickle cell anemia in a low-resource setting: a comparative study

Cited by 3 publications

References 27 publications

The Association Between Anemia and Depressive Symptoms in Non-White Male Adults: National Health and Nutrition Examination Survey (2005–2018)

The Association Between Anemia and Depressive Symptoms in Non-White Male Adults: National Health and Nutrition Examination Survey (2005–2018)

Precariousness Represents an Independent Risk Factor for Depression in Children With Sickle Cell Disease

Interacción Entre la Depresión y la Nutrición en Adolescentes: Explorando el Vínculo con la Anemia

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