Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part I. Physiologic and Pathophysiologic Features

Nishimura, Rick A.; Housmans, Philippe R.; Hatle, Liv; Tajik, A. Jamil

doi:10.1016/s0025-6196(12)65305-1

Cited by 236 publications

(93 citation statements)

References 89 publications

(113 reference statements)

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“…Mechanisms that might cause RV dysfunction in OSA patients include repetitive nocturnal arterial oxygen desaturation and hypercapnia, large intrathoracic negative-pressure periods, and increases in pulmonary artery pressure. 26,27 In animal models, intermittent hypoxia resulted in pulmonary artery remodeling and RV hypertrophy. 28 Moreover, in OSA patients, hypoxic or hypercapnic periods and oxidative stress lead to pulmonary vasoconstriction and endothelial dysfunction, which causes pulmonary remodeling.…”

Section: Discussionmentioning

confidence: 99%

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Akyol¹,

Çörtük²,

Baykan³

et al. 2016

Texas Heart Institute Journal

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Section: Discussionmentioning

confidence: 99%

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Akyol¹,

Çörtük²,

Baykan³

et al. 2016

Texas Heart Institute Journal

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“…In clinical practice, pulsed Doppler of LV inflow is extensively applied for noninvasive estimation of LV diastolic function in human and small animal patients [18,19,27,28,37]. However, E and E/A derived from the pulsed Doppler of LV inflow have the potential to show pseudonormalization of LV diastolic function [12,28,42,44].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Left Ventricular Function Using Pulsed Tissue Doppler Imaging in Healthy Dogs and Dogs with Spontaneous Mitral Regurgitation

et al. 2005

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ABSTRACT. Pulsed tissue Doppler imaging (pulsed TDI) has been demonstrated to be useful for the estimation of left ventricular (LV) systolic and diastolic functions in various human cardiac diseases. The objectives of this study were to investigate the relationship between pulsed TDI and LV function by using cardiac catheterization in healthy dogs and to evaluate the clinical usefulness of pulsed TDI in dogs with spontaneous mitral regurgitation (MR). The peak early diastolic velocity (E'), peak atrial systolic velocity (A'), and peak systolic velocity (S') were detectable in the velocity profiles of the mitral annulus in all the dogs. In the healthy dogs, S' and E' were correlated with LV peak +dP/dt and -dP/dt, respectively. E' was lower in dogs with MR than in dogs without cardiac diseases. E/E' in the MR dogs with decompensated heart failure was significantly increased in comparison with those with compensated heart failure. The sensitivity and specificity of the E/E' cutoff value of 13.0 for identifying decompensated heart failure were 80% and 83%, respectively. In addition, E/E' was significantly correlated with the ratio of left atrial to aortic diameter. These findings suggest that canine pulsed TDI can be applied clinically for estimation of cardiac function and detection of cardiac decompensation and left atrial volume overload in dogs with MR. KEY WORDS: canine, cardiac function, echocardiography, mitral regurgitation, pulsed tissue Doppler.J. Vet. Med. Sci. 67(12): 1207-1215, 2005 Doppler echocardiography is a predominant noninvasive modality that provides a large variety of useful information on cardiac conditions in human and small animal patients. Pulsed tissue Doppler imaging (pulsed TDI) derived from Doppler echocardiography can quantify the velocity of myocardial wall and/or valve annulus motions [30,31,40]. In humans, pulsed TDI of the mitral annulus and myocardial wall has been demonstrated to reflect the systolic and diastolic left ventricular (LV) function in normal subjects [30,45] and patients with dilated cardiomyopathy (DCM) [22,46], hypertrophic cardiomyopathy (HCM) [36,39,46], restrictive cardiomyopathy (RCM) [14,16,35], constrictive pericarditis [14,16,35], ischemic heart diseases [4,31,43,46], heart failure [1,24], mitral regurgitation (MR) [2,3,17], atrial fibrillation [29], arterial hypertension [13,46], and cardiac amyloidosis [20].Analysis of pulsed TDI revealed that the peak early diastolic velocity (E'), peak atrial systolic velocity (A'), and peak systolic velocity (S') are typically derived from the velocity profiles of myocardial or valve annulus motions (Fig. 1) [30]. Several studies have revealed that E' and A' are correlated with LV diastolic function [1,13,16,20,24,26,31,36,39,40,45], and S' is correlated with LV systolic function [17,20,22,29,30,43,46]. E' was almost independent of preload and showed no pseudonormal pattern in contrast to the peak early diastolic velocity of LV inflow (E) [5,24]. In addition, a ratio of E to E' (E/E') showed good correlation with pulmo...

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“…Left ventricular diastolic function is commonly assessed by studying the pattern of ventricular filling through the mitral valve. 83 The generally used diastolic function parameter is the E/A ratio. Our meta-analysis demonstrated a normal or slightly enhanced diastolic function in athletes compared with sedentary control subjects.…”

Section: Cardiac Functionmentioning

confidence: 99%

The Athlete’s Heart

Pluim

Zwinderman²,

Laarse³

et al. 2000

Circulation

861

293

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Background-It has been postulated that depending on the type of exercise performed, 2 different morphological forms of athlete's heart may be distinguished: a strength-trained heart and an endurance-trained heart. Individual studies have not tested this hypothesis satisfactorily. Methods and Results-The hypothesis of divergent cardiac adaptations in endurance-trained and strength-trained athletes was tested by applying meta-analytical techniques with the assumption of a random study effects model incorporating all published echocardiographic data on structure and function of male athletes engaged in purely dynamic (running) or static (weight lifting, power lifting, bodybuilding, throwing, wrestling) sports and combined dynamic and static sports (cycling and rowing

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Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part I. Physiologic and Pathophysiologic Features

Cited by 236 publications

References 89 publications

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Assessment of Left Ventricular Function Using Pulsed Tissue Doppler Imaging in Healthy Dogs and Dogs with Spontaneous Mitral Regurgitation

The Athlete’s Heart

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