Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

Wood, Lisa G.; Attia, John; McElduff, Patrick; McEvoy, Mark; Gibson, Peter G.

doi:10.1038/ejcn.2010.68

Cited by 30 publications

(19 citation statements)

References 43 publications

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“…The negative association between DII and both IL-6 and lung function that we observed concurs with a previous study that we conducted in another cohort from the general population in Australia, where plasma IL-6 and %total energy as dietary fat were found to be negative predictors of FEV 1 in males [22]. A number of other studies have suggested that dietary intake of foods known to have pro-or anti-inflammatory effects may be related to altered respiratory outcomes.…”

Section: Discussionsupporting

confidence: 92%

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma

Wood

Shivappa

Berthon

et al. 2014

Clin Experimental Allergy

247

210

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Background Asthma prevalence has increased in recent years and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the Dietary Inflammatory Index (DII) has been developed and validated to assess the inflammatory potential of individual diets. Objective This study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation. Methods Subjects with asthma (n=99) and healthy controls (n=61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results The mean DII score for the asthmatics was higher than the DII score for healthy controls (−1.40 versus −1.86, p=0.04), indicating their diets were more pro-inflammatory. For every 1 unit increase in DII score the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; p=0.040). FEV1 was significantly associated with DII score (β=−3.44, 95% CI: −6.50,−0.39; p=0.020), indicating that for every 1 unit increase in DII score, FEV1 decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (β=0.13, 95% CI: 0.05, 0.21;p=0.002). Conclusion and clinical relevance As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.

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Section: Discussionsupporting

confidence: 92%

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma

Wood

Shivappa

Berthon

et al. 2014

Clin Experimental Allergy

247

210

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“…Significant P ‐values for trends were reported for associations with COPD breathlessness across quartiles of PUFA and n‐6 fatty acid intakes, but not n‐3 fatty acids or (n‐3) : (n‐6) ratio. In contrast with the other papers referenced earlier, this study excluded fatty acids from cooking oils, margarine, butter, mayonnaise and salad dressings, and may therefore have underestimated actual intake levels.…”

Section: Resultsmentioning

confidence: 94%

“…In the much smaller population‐based Hunter Community Study, comprising 195 Australian men and women aged 55–85 years (including 45 subjects with FEV 1 < 80% of predicted), no cross‐sectional associations were found between dietary intake of saturated fatty acids, monounsaturated fatty acids, n‐3 PUFA and n‐6 PUFA with FEV 1 , FVC or FEV 1 /FVC. The study did find that higher fat intake (as a percentage of total energy intake) was associated with lower FEV 1 and FVC among men, but from these data, it cannot be concluded that specific fatty acids account for these associations.…”

Section: Resultsmentioning

confidence: 96%

Dietary fibre and fatty acids in chronic obstructive pulmonary disease risk and progression: a systematic review

et al. 2013

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Dietary intake attracts increasing interest in the risk for and progression of chronic obstructive pulmonary disease (COPD). In particular, dietary fibre and fatty acids have drawn specific attention for their immunomodulating potential. The study aimed to review the current evidence on the potential roles of dietary fibre or fatty acid intake in the risk and progression of COPD. Pubmed, EMBASE, Cochrane Collaboration Database and conference databases for original studies in adults addressing the association between fibre or fatty acid intake and COPD in terms of risk, lung function and respiratory symptoms were searched. Nine articles were included of which four reported on dietary fibre and five on fatty acids. Data of studies could not be pooled because of methodological diversity. Greater intake of dietary fibre has been consistently associated with reduced COPD risk, better lung function and reduced respiratory symptoms. Results on the associations between fatty acids and COPD are inconsistent. Dietary quality deserves further attention in developing COPD prevention and management programs.

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“…[30] IL-6 was identified as negatively associated with FVC. [31] Wang et al [32] had suggested that the IL-12 level was significantly lower in asthma patients, and the IL-12 level was positively associated with FEV1. Consequently, it is believed that IL-4, IL-6, and IL-12 levels in PB were associated with lung function and cellular immune function in children with moderate-to-severe asthma.…”

Section: Discussionmentioning

confidence: 99%

Associations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma

Cui

Zhao²,

ShuXiang³

et al. 2017

Medicine

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Background:Pediatric asthma has gained increasing concerns with poorly understood pathogenesis. The purpose of this study was to explore the associations of interleukin-4 (IL-4), IL-6, and IL-12 levels in peripheral blood (PB) with lung function, cellular immune function, and children's quality of life (QOL) with moderate-to-severe asthma.Methods:A total of 1158 children with moderate-to-severe asthma (the experimental group) and 1075 healthy children (the control group) were recruited for our study. Enzyme-linked immunosorbent assay was used to detect IL-4, IL-6, and IL-12 levels. T lymphocytes were detected by alkaline phosphatase antialkaline phosphatase, and erythrocyte immune was measured by red blood cell C 3b receptor (RBC-C3bR) rosette-forming test. The forced expiratory volume in 1 second (FEV1) and peak expiratory flow (PEF) were detected, after which FEV1/forced vital capacity (FVC) was calculated before and after treatment. PedsQL3.0 was used to measure the effect of asthma on QOL of children, and the correlation between IL-4, IL-6, and IL-12 levels and the lung function and QOL was measured. Logistic regression analysis was applied to detect related factors of moderate-to-severe asthma of children.Results:After treatment, the decreased IL-4 and IL-6 levels and increased IL-12 level were revealed in the experimental group. The cellular immune function's disorder was significantly decreased, and an elevated CD3, CD4, CD8, and declined CD4/CD8 level was performed in T lymphocytes. RBC-C3bR was increased, and red blood cell immune complex (RBC-IC) was reduced in erythrocyte immune in comparison with those before treatment. Lung function parameters all increased. After treatment, the symptoms of asthma in children reduced with scores of increased QOL. IL-4 was positively related to RBC-IC, but negatively associated with the QOL score. IL-6 showed negative connection with CD4/CD8, RBC-C3bR, FEV1/FVC, and QOL score, and had positive connection with PEF. In addition, IL-12 was negatively correlated with PEF. The levels of IL-4, RBC-C3bR, FEV1/FVC, and PEF were independent risk factors for the prognosis of treatment for children with moderate-to-severe asthma.Conclusion:This study demonstrated that IL-4, IL-6, and IL-12 levels in PB were associated with lung function, cellular immune function, and QOL in children with moderate-to-severe asthma.

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Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

Cited by 30 publications

References 43 publications

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma

Dietary fibre and fatty acids in chronic obstructive pulmonary disease risk and progression: a systematic review

Associations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma

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