Assessment of Differences in HLA-A, -B, and -DRB1 Allele Mismatches Among African-American and non–African-American Recipients of Deceased Kidney Transplants

HLA-A amino acid polymorphism and delayed kidney allograft function

“…In this cohort, the frequency of HLA-A, -B, and -DRB1 antigen mismatches in donor-recipient pairs and the degree and distribution of allele mismatches among recipients with no mismatch or one antigen mismatch were previously reported (14). In recipients with a zero antigen (serologic) mismatch at HLA-A, -B, or -DR, the frequency of one or two HLA allele (high resolution) mismatches were 10.7%, 28.7%, and 47.2%, respectively, in the entire cohort.…”

“…These findings remained similar after modeling HLA antigen mismatches categorically, as 0, 1, or 2 (data not shown). Interestingly, we have previously reported in this cohort that HLA-A amino acid residues at peptide contact sites were frequently mismatched among donorrecipient pairs who have one or two mismatches at the allele level, but are matched at the antigen level (14). These findings suggested that amino acid mismatches at functionally important sites may be associated with DGF and prompted us to evaluate these potential associations further.…”

“…We enrolled 705 recipients of deceased-donor renal transplants into a prospective cohort study during the period April 1998 through November 2001, as previously described (14). Patients were recruited at the time of transplantation from eight centers served by the Gift of Life Donor Program in eastern Pennsylvania, as previously reported (15).…”

“…In recipients with a zero antigen (serologic) mismatch at HLA-A, -B, or -DR, the frequency of one or two HLA allele (high resolution) mismatches were 10.7%, 28.7%, and 47.2%, respectively, in the entire cohort. Among recipients with one antigen mismatch at HLA-A, -B, or -DR, additional allele mismatches were observed in 9.6%, 21.9%, and 33% respectively (14). None of three ordinal terms for HLA antigen mismatches at the A, B, and DR loci was associated with DGF in an unadjusted logistic regression model (Table 1).…”

“…A total of 705 donor-recipient pairs were enrolled into a longitudinal cohort study of transplantation, as previously described (14,15). The racial distribution was as follows: 498 (70.6%) were non-African Americans (AA) and 207 were AA (29.4%).…”