Painters experience occupational exposure through inhalation
and
skin absorption to various chemicals that are used as ingredients
of paint mixtures and other related painting trades. Although several
investigations indicated significant contribution of exposure via
skin absorption to exhibit harmful effects on health among painters,
assessment of the skin absorption hazards of the paint chemicals is
limited. Here, we evaluated the skin absorption of a number of organic
chemicals relevant to painting trades using mathematical models. For
this purpose, we estimated the skin permeability coefficient of the
chemicals using the Potts and Guy correlation equation. The estimated
permeability coefficients were further utilized to estimate the maximum
flux of the non-volatile chemicals across the skin. The skin permeability
coefficient and maximum flux of the chemicals across the skin were
compared to those of the chemicals to which the American Conference
of Governmental Industrial Hygienists (ACGIH) assigned a “skin”
notation. We critically analyzed the estimated maximum fluxes and
the acute toxicity data of the chemicals available in the literature
that helped to identify the chemicals posing a significant skin absorption
hazard. The analyses suggest that triethanolamine and m-phenylenediamine pose significant skin absorption hazards, though
these chemicals have not yet been assigned a “skin”
notation in the ACGIH TLV book. The ratio of dermal uptake directly
from air to inhalation intake of volatile solvents used in paint mixtures
was estimated for a typical occupational setting. N-Methyl-2-pyrrolidone showed significant dermal uptake fraction compared
to its intake via inhalation route.