Assessment of dim light melatonin onset based on plasma and saliva samples

Dermanowski, Michał; Hejduk, Arkadiusz; Kuczyńska, Julita; Wichniak, Adam; Urbańska, Agnieszka; Mierzejewski, Paweł

doi:10.1080/07420528.2021.2016796

Cited by 8 publications

(9 citation statements)

References 40 publications

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“…The melatonin concentration in saliva and plasma, as well as DLMO, is highly correlated at r = 0.76, and r = 0.69, respectively. According to our previous study in healthy adults, the average DLMO time was 21:30 ± 0:45 [1], which was similar to the results of other studies [2][3][4][5].…”

Section: Introductionsupporting

confidence: 90%

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Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers

Dermanowski,

Wichniak,

Hejduk

et al. 2023

JCM

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Dim light melatonin onset (DLMO) is considered the most reliable marker of the circadian rhythm phase in humans. DLMO may moderately correlate with sleep onset and sleep offset time. There are no sufficient data about the correlations between DLMO and clinical scales assessing sleep quality and daytime symptoms of poor night sleep. The aim of the study was to determine the association between DLMO and basic sleep parameters from actigraphy and sleep diaries, as well as the association between DLMO and the following insomnia clinical scales: the Athens Insomnia Scale (AIS), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and chronotype questionnaires: Morningness–Eveningness Questionnaire (MEQ) and Composite Scale of Morningness (CSM). Participants of the study were healthy volunteers. Sleep parameters were measured by sleep diaries and actigraphy, and the following clinical scales: the AIS, ISI, and ESS, and chronotype questionnaires: MEQ and CSM. DLMO was calculated based on plasma melatonin concentration. The blood samples were collected hourly at five time points between 20:00 and 00:00 during the session in dim red light (<50 lux). Melatonin concertation was determined by LC-MS/MS. Twenty-one volunteers participated in the study. DLMO was calculated in 12 participants. There was a significant correlation between DLMO and ISI (r = 0.60, p = 0.038) and ESS (r = 0.61, p = 0.034). The correlation coefficient between the DLMO and the AIS was also high, however insignificant (r = 0.57, p = 0.054). There were no significant correlations between DLMO and chronotype scales MEQ and CSM. DLMO did not correlate with sleep onset and sleep offset; however, DLMO correlated with the Sleep Fragmentation Index (SFI) (r = 0.67, p = 0.017). DLMO is associated with poorer sleep maintenance, a stronger feeling of insomnia, and sleepiness during the day. Simultaneously, chronotype pattern and circadian rhythm parameters do not correlate with DLMO. Biological circadian rhythm does not reflect the real-life sleep–wake rhythm, indicating that the lifestyle is more often disconnected from the biological clock.

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Section: Introductionsupporting

confidence: 90%

“…DLMO is determined by measuring melatonin concentration during the evening and night hours. DLMO can be determined from both plasma and saliva samples [1]. The melatonin concentration in saliva and plasma, as well as DLMO, is highly correlated at r = 0.76, and r = 0.69, respectively.…”

Section: Introductionmentioning

confidence: 99%

Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers

Dermanowski,

Wichniak,

Hejduk

et al. 2023

JCM

Self Cite

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“…The exogenous melatonin can be administered orally or intravenously and its concentration can be assessed by blood, saliva and so on. It is considered a more convenient and accessible approach to provide greater comfort to patients and improve their quality of life ( Dermanowski et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Zhang

Lang²,

Guo³

et al. 2022

Front. Neurosci.

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Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.

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“…In addition to its heterogeneous spatial distribution, saliva is also under circadian control, displaying daily variations in flow rate and composition. 6 , 10 Salivary metabolites such as melatonin 11 , 12 , 13 and cortisol 14 , 15 , 16 , 17 are used as circadian biomarkers. The circadian rhythm regulates many aspects of mammalian physiology ranging from energy homeostasis to sleep to the detoxification of xenobiotics.…”

Section: Introductionmentioning

confidence: 99%

Spatially and temporally resolved metabolome of the human oral cavity

Ciurli,

Mohammed,

Ammon

et al. 2024

iScience

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Assessment of dim light melatonin onset based on plasma and saliva samples

Cited by 8 publications

References 40 publications

Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers

Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers

Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Spatially and temporally resolved metabolome of the human oral cavity

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