2018
DOI: 10.1111/ijcp.13261
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Assessment of discharge treatment prescribed to women admitted to hospital for hyperemesis gravidarum

Abstract: Aims Prescribing drug treatment for the management of hyperemesis gravidarum (HG), the most severe form of nausea and vomiting in pregnancy, remains controversial. Since most manufacturers do not recommend prescribing antiemetics during pregnancy, little is known regarding which treatments are most prevalent among pregnant patients. Here, we report for the first time, evidence of actual treatments prescribed in English hospitals. Methods A retrospective pregnancy cohort was constructed using anonymised electro… Show more

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Cited by 4 publications
(5 citation statements)
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“…49,51 The increased use of ondansetron to treat NVP, which is evident from the management of women screened for participation in the EMPOWER trial, is consistent with a recent report of antiemetic discharge prescriptions from one large UK trust between 2010 and 2015. 52 Following the first admission with HG, 45% of women were discharged with ondansetron [either alone (8.5%) or in combination with another antiemetic (37.0%)], compared with 27.5% with metoclopramide (3.7% alone and 23.8% in combination). The rates of ondansetron and metoclopramide prescription increased to 72.9% and 44.9%, respectively, for subsequent admissions.…”
Section: Chapter 5 Discussionmentioning
confidence: 99%
“…49,51 The increased use of ondansetron to treat NVP, which is evident from the management of women screened for participation in the EMPOWER trial, is consistent with a recent report of antiemetic discharge prescriptions from one large UK trust between 2010 and 2015. 52 Following the first admission with HG, 45% of women were discharged with ondansetron [either alone (8.5%) or in combination with another antiemetic (37.0%)], compared with 27.5% with metoclopramide (3.7% alone and 23.8% in combination). The rates of ondansetron and metoclopramide prescription increased to 72.9% and 44.9%, respectively, for subsequent admissions.…”
Section: Chapter 5 Discussionmentioning
confidence: 99%
“…Many women will require a combination of two or more antiemetics. 46 A slow-release combination of doxylamine and pyridoxine (vitamin B 6 ) called Xonvea®™ is the only licensed treatment of NVP in the UK. 44 A delayed-release formulation containing 10 mg doxylamine succinate and 10 mg pyridoxine hydrochloride has been available in Canada since 1979 and since 2013 in the USA.…”
Section: +mentioning
confidence: 99%
“…Clinicians should use antiemetics with which they are familiar and should use drugs from different classes if the first drug is not effective or only partially effective. Many women will require a combination of two or more antiemetics 46 …”
Section: How Should Women With Nvp and Hg Be Cared For?mentioning
confidence: 99%
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“…It is commonly used ‘off-label’ to treat NVP/HG, in particular for inpatient management, where it is frequently prescribed. 3…”
mentioning
confidence: 99%