Assessment of Disease Activity and Progression of Osteoarthritis With Using Molecular Markers of Cartilage and Synovium Turnover

Abstract

Osteoarthritis (OA) is the most common joint disease, which is characterized by cartilage loss and concomitant alteration of synovium and subchondral bone metabolism. Pain and stiffness in the affected joints are the main complains. It also causes physical functional impairment. The measurement of joint space width by plain radiography is currently established method for assessing the progression of the disease. This method however has some limitations. The most important issue is to determine early OA before significant joint damage has occurred. When there is radiological evidence of OA, significant joint damage has often already occurred. Therefore, there is need for noninvasive methods that can be repeated and have better sensitivity than plain radiography to identify patients at high risk for destructive OA and monitoring drug efficacy.Molecular markers are released into biological fluids during tissue biosynthesis and turnover. They can be measured by immunoassay. Several molecular markers of bone, cartilage and synovium have been described such as crosslinking telopeptide of collagen type II (CTX II), Glc-Gal-PYD, hyaluronic acid, type I collagen.In conclusion, using a newly developed molecular marker, early OA can be properly detected before significant joint destruction has occurred.

Osteoarthritis diagnosis using wear particle analysis technique: Investigation of correlation between particle and cartilage surface in walking process

“…Current methods to assess the severity of OA include arthroscopic surgery, which is intrusive and experience dependent; plain radiography which poorly correlates with clinical symptoms; or magnetic resonance imaging (MRI) which is expensive and not readily available [3]. One of the major difficulties in OA management is the lack of ability to accurately predict the rate and factors influencing progression of joint surface degeneration.…”

Use of serum biomarkers to predict the development and severity of osteochondrosis lesions in the distal portion of the femur in pigs

“…15,21 By use of antibody detection assays, differences in concentrations of these specific proteins in various samples from unaffected and affected animals have been detected. 22 Cartilage and bone metabolism markers have been correlated with disease state with some success and have been used to determine treatment effectiveness in several different animal models of osteoarthritis 23,24 and OC [25][26][27] ; however, only a few biomarkers of bone turnover have been evaluated in swine. [28][29][30] Therefore, the objective of the study of this report was to evaluate the use of serum biomarkers of cartilage and bone metabolism to predict the occurrence and severity of OC lesions in the distal portion of femurs in growing pigs.…”

Effectiveness of Mobilization with Movement on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

“…Osteoarthritis (OA) is a chronic degenerative disease characterized by the deterioration of the cartilage in the joints, creating stiffness, pain, and impaired movement [ 1 , 2 ]. Osteoarthritis a leading cause of pain and functional disability in both developed and developing countries, especially in the elderly population [ 3 , 4 ].…”