Assessment of disease activity and damage in SLE: Are we there yet?

Effect of Sustained Clinical Remission on the Risk of Lupus Flares and Impaired Kidney Function in Patients With Lupus Nephritis

“…SLEDAI and SLEDAI-2K have been incorporated in SLE responder indexes as well as in the definitions of remission and low disease activity. 33 Acute kidney damage: eGFR <60 ml/min per 1.73 m 2 for <3 months, hematuria (urinary red blood cells >20/high power field), and/or erythrocyte casts, proteinuria ≥0.5 g/d 34 ; nephrotic syndrome: proteinuria ≥3.5 g/d, serum albumin ≤3 g/dl; isolated urinary abnormalities: normal renal function, proteinuria <3.5 g/d and ≥0.5 g/d and/or microscopic hematuria; IKF: eGFR <60 ml/min per 1.73 m 2 34 for at least 3 months; kidney failure: need of chronic dialysis or eGFR <15 ml/min per 1.73 m 2 ; arterial hypertension: the mean of 3 consecutive measurements of systolic blood pressure >140 mm Hg and/or diastolic blood pressure >90 mm Hg in sitting position; nephritic flares: increase in serum creatinine of at least 30% over the last value, associated with nephritic urinary sediment, with or without increased proteinuria 8 ; proteinuric flares: increase in proteinuria without modification of serum creatinine of at least 2 g/24h if the previous proteinuria was <3.5 g/24h, or doubling if previous proteinuria was ≥3.5 g/24h; 8 extrarenal flares were defined according to revised Safety of Estrogens in Lupus Erythematosus National Assessment-SLEDAI criteria. 35 , 36…”