Assessment of DNA damage in coal open-cast mining workers using the cytokinesis-blocked micronucleus test and the comet assay

León-Mejía, Grethel; Espitia-Pérez, Lyda; Hoyos-Giraldo, Luz Stella; Silva, Juliana da; Hartmann, Andreas; Henriques, João Antônio Pêgas; Quintana, Milton

doi:10.1016/j.scitotenv.2010.10.049

Cited by 87 publications

(37 citation statements)

References 43 publications

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“…León-Mejía et al, evaluated genotoxic effects in a population exposed to coal residues from the open-cast mine "El Cerrejón". They included in this study 100 exposed workers and 100 non-exposed control individuals [63]. These results indicate that exposure to coal mining residues may result in an increased genotoxic exposure in coal mining workers, the mean values of the Comet assay variables of the two study groups was demonstrated increased levels of DNA damage in the exposed group compared to the non-exposed control group.…”

Section: Recents Studies Using Comest Assaymentioning

confidence: 61%

“…These results indicate that exposure to coal mining residues may result in an increased genotoxic exposure in coal mining workers, the mean values of the Comet assay variables of the two study groups was demonstrated increased levels of DNA damage in the exposed group compared to the non-exposed control group. No difference was observed between the exposed groups executing different mining activities [63]. Villani et al, tested bull sperm treated with additional mutagens (bleomycin colchicine, diethylsulfate and mitomycin C) with the standard comet assay, mutagenisis effect of diethylsulfate was obtained with themodified assay is dose-dependent, according to their study treatment with colchicine don't causes DNA lesions [64].…”

Section: Recents Studies Using Comest Assaymentioning

confidence: 99%

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Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Gharsalli¹

2016

J Environ Anal Toxicol

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Section: Recents Studies Using Comest Assaymentioning

confidence: 61%

Section: Recents Studies Using Comest Assaymentioning

confidence: 99%

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Gharsalli¹

2016

J Environ Anal Toxicol

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“…Despite its poor environmental reputation, coal represents an important source of energy worldwide (Zakrzewski 1991, Chen et al 2005, Bhuiyan et al 2010, León-Mejia et al 2011, Council 2013 because between 27% (Bhuiyan et al 2010) and 40% (Council 2013) of the world's energy consumption originates from incineration of coal.…”

Section: Introductionmentioning

confidence: 99%

“…Overall, the system of coal energy production involves coal-mining, mineral processing, coal burning, and subsequent energy generation, whereas the environmental challenges from coal exploitation include coal mine accidents (Bian et al 2010), land subsidence (Bian et al 2010, Sadhu et al 2012, damage to the water and terrestrial environment (Bian et al 2010, 2014, Sadhu et al 2012, Wang et al 2013), especially to the vegetation (Donggan et al 2011) and to soil structure (Ghose 1996, Dutta and Agrawal 2002, Banerjee et al 2004, Sadhu et al 2012, Wang et al 2013, mining waste disposal (Singh and Singh 2006, Bian et al 2010, Bhuiyan et al 2010, Wang et al 2013, air pollution (Querol et al 2008, Zhao et al 2008, León-Mejia et al 2011, and landscape changes (Bian et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Elemental composition of vegetables cultivated over coal-mining waste

Zocche

Rohr

Damiani

et al. 2017

An. Acad. Bras. Ciênc.

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We assessed elemental composition of the liver in mice subjected to one-time or chronic consumption of the juice of vegetables cultivated in a vegetable garden built over deposits of coal waste. Lactuca sativa L. (lettuce), Beta vulgaris L. (beet), Brassica oleracea L. var. italica (broccoli) and Brassica oleracea L. var. acephala (kale) were collected from the coal-mining area and from a certified organic farm (control). Elemental composition was analyzed by particle-induced X-ray emission (PIXE) method. Concentrations of Mg, S, and Ca of mice subjected to one-time consumption of broccoli and concentrations of these same elements plus Si of mice receiving kale were higher in the coal-mining area. Concentrations of P, K, and Cu were increase after chronic consumption of lettuce from the coal-mining area, whereas the levels of Si, P, K, Fe, and Zn were higher in the group consuming kale from the coal-mining area. Our data suggests that people consuming vegetables grown over coal wastes may ingest significant amounts of chemical elements that pose a risk to health, since these plants contain both essential and toxic metals in a wide range of concentrations, which can do more harm than good.

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“…En 37,7 % de los centros de trabajo del departamento de Boyacá, se ha determinado que el material en partículas es un factor de riesgo respiratorio (18). A pesar de estas cifras, el estudio de los posibles impactos de la minería del carbón en la salud son incipientes y hay muy pocas referencias de la gran prevalencia de síntomas respiratorios y alteración de la función respiratoria, relacionada con la explotación del carbón (19)(20)(21)(22)(23)(24)(25)(26).…”

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Spirometry in a population of coal miners in Paipa, Colombia

et al. 2017

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Introducción: Las enfermedades respiratorias derivadas de la exposición a material en partículas, como sucede en la minería del carbón, continúa siendo un reto investigativo en el país y un problema de salud pública. La espirometría es una prueba de la función respiratoria, fundamental para el diagnóstico y la vigilancia de este tipo de enfermedades pulmonares crónicas.Objetivo. Determinar los valores de la espirometría en la población minera de carbón del municipio de Paipa, y su asociación con la edad y el tiempo de exposición laboral.Materiales y métodos. Se hizo un estudio descriptivo de corte transversal. Se diligenció el cuestionario de enfermedad respiratoria ocupacional de la American Thoracic Society (ATS), se registraron las mediciones de la espirometría y se interpretaron siguiendo las recomendaciones internacionales.Resultados. La muestra incluyó 226 trabajadores de minas de carbón de Paipa; en 12,3 % (n=28) de ellos se registraron alteraciones leves, de tipo obstructivo o restrictivo. En 35 % (n=80) hubo disminución de la relación entre la capacidad vital forzada y el volumen espirado en el primer segundo (CVF/VEF1). Se encontró una asociación estadísticamente significativa entre el rango de edad (p=0,002) y los años de trabajo minero (p=0,34), además de trastornos restrictivos y obstructivos. Asimismo, hubo una asociación estadísticamente significativa entre el rango de edad (p<0,01) y los años de trabajo minero (p<0,01), de diferente seriedad en el patrón de las mediciones de la espirometría.Conclusiones. La espirometría es una prueba útil para detectar la presencia de trastornos respiratorios en la población minera del carbón. La enfermedad respiratoria en estos mineros estuvo significativamente asociada con el tiempo de exposición.

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Assessment of DNA damage in coal open-cast mining workers using the cytokinesis-blocked micronucleus test and the comet assay

Cited by 87 publications

References 43 publications

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Elemental composition of vegetables cultivated over coal-mining waste

Spirometry in a population of coal miners in Paipa, Colombia

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