Assessment of Dog Owner Concern Regarding Peri-operative Nausea and Vomiting and Willingness to Pay for Anti-emetic Treatment

Kraus, Bonnie L. Hay; Cazlan, Callie E

doi:10.3389/fvets.2019.00264

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…(2019) also determined that many canine owners are aware of the discomfort and negative in uence of nausea on animal welfare and would accept higher costs and longer hospital stays in return for an effective relief for their pets. 35 Golden Retriever (n = 4) and mixed-breed dogs (n = 2) were most likely to have a diagnosis of 'vestibular syndrome' in this case series. Bongartz et al (2020) also found mixed-breed dogs (15.1%) to be most likely affected.…”

Section: Discussionmentioning

confidence: 78%

The Use of Ondansetron for the Treatment of Nausea in Dogs With Vestibular Syndrome

Foth

Meller

Kenward

et al. 2021

Preprint

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Background: Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5‑HT3 receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders.Methods: Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentric study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed.Results: All dogs initially showed signs of nausea, whereas only 31% showed vomitus. The intensity of nausea was significantly reduced in all dogs (p≤0.0001) 2 h after ondansetron administration, including the clinical signs of nausea analysed in 11 dogs (salivation [p=0.0078], lip licking [p=0.0078], restlessness [p=0.0039], and lethargy [p=0.0078]) except for vocalisation (p>0.9999).Conclusion: The results provide preliminary evidence of the potential benefit of ondansetron in the treatment of nausea, which was present in all examined dogs. Vomiting was only observed in 5 dogs indicating that nausea can occur separately and should not be perceived only as a preceding stimulation of the vomiting centre.

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Section: Discussionmentioning

confidence: 78%

The Use of Ondansetron for the Treatment of Nausea in Dogs With Vestibular Syndrome

Foth

Meller

Kenward

et al. 2021

Preprint

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“…Research has shown that pet owners are willing to pay more, arrive earlier, and wait longer to prevent their pets from vomiting and feeling nauseated. 15 An ideal premedication protocol would be one that provides adequate pain control and sedation while decreasing the frequency of vomiting and nausea. Two different antiemetics-maropitant and ondansetron-are commonly used in dogs.…”

Section: S41mentioning

confidence: 99%

Effectiveness of orally administered maropitant and ondansetron in preventing preoperative emesis and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate

Burke¹,

Hess²,

Silverstein³

2022

javma

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OBJECTIVE To compare effectiveness of maropitant and ondansetron in preventing preoperative vomiting and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate. ANIMALS 88 dogs owned by rescue organizations. PROCEDURES Dogs received maropitant (n = 29) or ondansetron (28) PO 2 hours prior to premedication or did not receive an antiemetic (31; control). Dogs were evaluated for vomiting, nausea, and severity of nausea (scored for 6 signs) for 15 minutes following premedication with hydromorphone, acepromazine, and glycopyrrolate. RESULTS A significantly lower percentage of dogs vomited after receiving maropitant (3/29 [10%]), compared with control dogs (19/31 [62%]) and dogs that received ondansetron (15/28 [54%]). A significantly lower percentage of dogs appeared nauseated after receiving maropitant (3/29 [10%]), compared with control dogs (27/31 [87%]) and dogs that received ondansetron (14/28 [50%]), and a significantly lower percentage of dogs appeared nauseated after receiving ondansetron, compared with control dogs. Nausea severity scores for hypersalivation, lip licking, hard swallowing, and hunched posture were significantly lower for dogs that received maropitant than for control dogs, and scores for hypersalivation, lip licking, and hard swallowing were significantly lower for dogs that received ondansetron than for control dogs. CONCLUSIONS AND CLINICAL RELEVANCE Oral administration of maropitant 2 hours prior to premedication with hydromorphone reduced the incidence of vomiting and the incidence and severity of nausea in healthy dogs. Oral administration of ondansetron reduced the incidence and severity of nausea but not the incidence of vomiting.

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“…A recent study 9 Low incidence of postoperative nausea, vomiting, regurgitation, and aspiration pneumonia in geriatric dogs receiving maropitant, famotidine, and fentanyl as part of an anesthesia protocol Ashley L. Moyer, VMD 1 *; Talon S. McKee 2 ; Philip J. Bergman, DVM, PhD 2 ; Arathi Vinayak, DVM 1 revealed an incidence of PONV in 50% of dogs undergoing routine ovariohysterectomy, and there is an emerging clinical interest in reducing PONV in veterinary patients. 10 However, most previous studies 2,11 have focused on PORV due to the objective nature of these events.…”

Section: Conclusion and Clinical Relevancementioning

confidence: 99%

Low incidence of postoperative nausea, vomiting, regurgitation, and aspiration pneumonia in geriatric dogs receiving maropitant, famotidine, and fentanyl as part of an anesthesia protocol

Moyer

McKee²,

Bergman³

et al. 2022

javma

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OBJECTIVE To determine the incidence of and potential risk factors for postoperative regurgitation and vomiting (PORV), postoperative nausea and vomiting (PONV), and aspiration pneumonia in geriatric dogs using premedication with maropitant and famotidine, intraoperative fentanyl, and postoperative fentanyl as part of an anesthetic protocol. ANIMALS 105 client-owned geriatric dogs that underwent general anesthesia for a major surgical procedure between January 2019 and March 2020. PROCEDURES Medical records were reviewed to collect data on signalment, historical gastrointestinal signs, American Society of Anesthesiologists (ASA) score, indication for surgery, duration of anesthesia and surgery, patient position during surgery, mode of ventilation, and perioperative administration of maropitant, famotidine, anticholinergics, opioids, colloidal support, NSAID, corticosteroids, and appetite stimulants. The incidence of postoperative regurgitation, vomiting, nausea, and aspiration pneumonia was calculated, and variables were each analyzed for their association with these outcomes. RESULTS 2 of 105 (1.9%) dogs regurgitated, 1 of 105 (1.0%) dogs developed aspiration pneumonia, 4 of 105 (3.8%) dogs exhibited nausea, and no dogs vomited. Identified possible risk factors included older age (≥ 13 years old) for postoperative regurgitation, regurgitation for postoperative aspiration pneumonia, and high ASA score (≥ 4) for both regurgitation and aspiration pneumonia. CONCLUSIONS AND CLINICAL RELEVANCE The use of an antiemetic protocol including maropitant, famotidine, and fentanyl in geriatric dogs resulted in very low incidences of PORV, PONV, and aspiration pneumonia. Future prospective studies are warranted to further evaluate and mitigate postoperative risks.

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Assessment of Dog Owner Concern Regarding Peri-operative Nausea and Vomiting and Willingness to Pay for Anti-emetic Treatment

Cited by 10 publications

References 34 publications

The Use of Ondansetron for the Treatment of Nausea in Dogs With Vestibular Syndrome

The Use of Ondansetron for the Treatment of Nausea in Dogs With Vestibular Syndrome

Effectiveness of orally administered maropitant and ondansetron in preventing preoperative emesis and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate

Low incidence of postoperative nausea, vomiting, regurgitation, and aspiration pneumonia in geriatric dogs receiving maropitant, famotidine, and fentanyl as part of an anesthesia protocol

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