Assessment of drug-related problems among type 2 diabetic patients on follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

Abdulmalik, Haymen; Tadiwos, Yohannes; Legese, Nanati

doi:10.1186/s13104-019-4760-8

Cited by 13 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 26 , 32 , 33 , 35 The remaining were from Southern Ethiopia and Eastern Ethiopia. The lion’s share of studies were conducted on a single disease such as diabetes mellitus 30 , 33 , 37 , 39 , 40 and hypertension. 29 , 36 The sample size in the included studies ranged from 103 35 to 418.…”

Section: Resultsmentioning

confidence: 99%

Drug-related problems in Ethiopian public healthcare settings: Systematic review and meta-analysis

Ayele

Tesfaye

2021

SAGE Open Medicine

View full text Add to dashboard Cite

Identification and prevention of drug-related problems have become the central role of patient-centered pharmacy practitioners. After the initiation of patient-oriented pharmacy service, many studies evaluating magnitude of drug-related problems at facility level in Ethiopia have been conducted, though the extent of the problem at a national level remains unknown. Hence, this systematic review and meta-analysis is undertaken with the aim of quantifying the prevalence of drug-related problems in Ethiopian public healthcare settings using Cipolle/Strand classification system. Electronic databases were searched including PubMed, EMBASE, Web of Science, MEDLINE and HINARI, Google Scholar and ResearchGate for both published and unpublished works. Data on study characteristics and outcomes were extracted using the format developed on Microsoft Excel. The primary measure was the pooled prevalence of drug-related problems. The meta-analysis was conducted using OpenMeta[Analyst].A total of 17 studies were included in this systematic review and meta-analysis. The pooled prevalence of drug-related problems of patients who experienced at least one drug-related problem during their therapy was found to be 69.4% (95% confidence interval: 61.5–77.4). The most frequently reported types of drug-related problems were “need for additional drug and “noncompliance,” together accounting for more than half of the drug-related problems. The most frequently reported factors associated with drug-related problems were patients’ age, polypharmacy, comorbidities and the number days of hospital stay.The prevalence of drug-related problems in Ethiopian public healthcare settings was found to be high. Inconsistent reporting of drug-related problems was observed across the studies. It is imperative to design and implement interventions aimed at reducing drug-related problems. Responsible stakeholders should adopt uniform drug-related problem classification approach to ensure uniform reporting of drug-related problems in Ethiopian healthcare settings

show abstract

Section: Resultsmentioning

confidence: 99%

Drug-related problems in Ethiopian public healthcare settings: Systematic review and meta-analysis

Ayele

Tesfaye

2021

SAGE Open Medicine

View full text Add to dashboard Cite

show abstract

“…Of the total included studies, eight studies were conducted in Jimma University Medical Center (JUMC) [26][27][28][29][30][31][32][33], seven were conducted in Tikur Anbesa Specialized Hospital [25,[34][35][36][37][38][39]. Three studies were conducted in Hiwot Fana Specialized University Hospital [40]- [42] and two studies were conducted in Dessie Referral Hospital [43,44]. Majority (n = 20) of the studies were conducted in ambulatory care [24, 25, 27, 30, 34-37, 39-42, 45-52], while eight studies were conducted in the medical wards [26,28,29,32,38,43,49,53].…”

Section: Characteristics Of the Studymentioning

confidence: 99%

“…Majority (n = 20) of the studies were conducted in ambulatory care [24, 25, 27, 30, 34-37, 39-42, 45-52], while eight studies were conducted in the medical wards [26,28,29,32,38,43,49,53]. Four studies were focused on hypertensive patients [45][46][47][48], four studies conducted among patients with diabetes [34,40,50,51] and six studies were conducted among heart failure patients [25,27,42,49,52,52]. Furthermore, two studies involved diabetic patients with comorbid hypertension [30,41] (Table 1).…”

Section: Characteristics Of the Studymentioning

confidence: 99%

Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Adem

Abdela

Edessa

et al. 2021

J of Pharm Policy and Pract

View full text Add to dashboard Cite

Background Drug-related problems (DRPs) can occur at any stages of medication use processes, and a single drug could be associated with multiple DRPs. Once happened, it adversely affects health outcomes. In Ethiopia, evaluation of the magnitude and factors associated with DRPs had not been attempted at the national level. Method The literature search was conducted in the following databases; PubMed, Embase, Medline, and Google Scholar. The quality of the included studies was checked using Joanna Brigg’s Institute (JBI’s) checklist, and data were analyzed using Stata software (version 14.0). The pooled estimate of DRPs was computed by a Random effect model (DerSimonian–Laird method). Cochran’s Q test (I2) statistic)), and Begg’s correlation and Egger’s regression test were assessed for heterogeneity and publication bias, respectively. Result Overall, 32 studies with a total sample size of 7,129 were included in the review. The estimated pooled prevalence of DRPs was 70% [0.70 (95% CI 0.64—0.76; I2 = 97.6% p = 0.000)]. Polypharmacy (taking ≥ 5 drugs) [RR = 1.3], medical comorbidity [RR = 1.3], poor medication adherence [RR = 1.7], uncontrolled blood pressure [RR = 1.4], substance use [RR = 1.2], type 2 diabetes [RR = 1.8], significant drug interaction [RR = 1.33], and a negative medication belief [RR = 3.72] significantly influenced the occurrence of DRPs. Conclusion The estimated national prevalence of DRPs in Ethiopia was high. Presence of medical comorbidity, using multiple drugs, significant drug interaction, poor medication adherence, uncontrolled blood pressure, type 2 diabetes, substance use and a negative belief about medication significantly influenced the occurrence of DRPs. Initiating and/or strengthening pharmaceutical care services at the health care facilities could lower the occurrence of DRPs. PROSPERO registration number CRD42020162329.

show abstract

“…The development of diabetic complications also results from the insufficient effectiveness of pharmacotherapy of synthetic drugs [3]. Given the aging population, the trend of developing diabetes and the limited efficacy of synthetic drug therapy will be increasing.…”

Section: Introductionmentioning

confidence: 99%

Herbal Infusions as a Valuable Functional Food

et al. 2021

View full text Add to dashboard Cite

Herbal infusions are an underestimated and easy to intake a source of biologically active natural compounds (polyphenols), which, in the dissolved form, are more easily absorbed. Therefore, this study aimed to assess the potential of herbal infusions as a functional food to reduce postprandial hyperglycemia (inhibition of α-amylase and α-glucosidase) and to reduce the effects of increased blood glucose level (antioxidant effect-DPPH, CUPRAC, and Fe2+ chelating assays, as well as anti-inflammatory activity-inhibition of collagenase). We showed that polyphenols are present in the examined aqueous herbal infusions (including chlorogenic and gallic acids). Subsequently, our research has shown that herbal infusions containing cinnamon bark, mulberry leaves, and blackberry fruits most strongly inhibit glucose release from complex carbohydrates, and that all herbal infusions can, to different degrees, reduce the effects of elevated blood sugar. In conclusion, infusions prepared from herbal blends could be recommended to prevent type II diabetes.

show abstract

Assessment of drug-related problems among type 2 diabetic patients on follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

Cited by 13 publications

References 17 publications

Drug-related problems in Ethiopian public healthcare settings: Systematic review and meta-analysis

Drug-related problems in Ethiopian public healthcare settings: Systematic review and meta-analysis

Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Herbal Infusions as a Valuable Functional Food

Contact Info

Product

Resources

About