Assessment of Drug Usage Pattern during Pregnancy at a Tertiary Care Teaching Hospital

Varghese, Bency Mary; Vanaja, K.; Banu, Reshma

doi:10.5530/ijmedph.2016.3.7

Cited by 10 publications

(19 citation statements)

References 9 publications

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“…In the current finding there was no drug used from FDA category X. This was similar with the study conducted in Adama [1], northern Ethiopia [8] and Banglore [36]. Studies indicated that there was a practice of prescribing drugs from category X in Omani (0.3%) [9], in Brazil (0.03%) [28], in Jimma, Ethiopia (7.4%) [10], in Bahirdar, Ethiopia (5.5%) [12], and in United States (4.6%) [11].…”

Section: Discussionsupporting

confidence: 91%

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

2018

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ObjectiveThis study is aimed to investigate drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia from March 1 to April 20, 2018.ResultA total of 369 pregnant women medical records were reviewed. The mean age of pregnant women was 24.34 (± 4.48) years and the majority of them were within the age of 18-25 years. About three-fourths (n = 277, 75.1%) of them were urban residents. Besides, 314 (85.1%) women had taken at least one drug with a total of 377 drugs prescribed. From which, supplemental drugs accounted majority of the drug therapy (84.88%) whereas non-supplemental drugs (15.12%) were used by 41 pregnant women during the review period. According to Food and Drug Administration FDA pregnancy risk classification, 320 (84.88%) drugs were prescribed from category A; 33 (8.75%) drugs were from category B; 19 (5.04%) drugs were from category C and 5 (1.33%) drugs were from category D. There was no drug prescribed from category X. As this result indicated, there is a decrease in the prevalence of drug use from Category A to X as the possibility of potential risk to fetus might outweigh the potential benefit to the mother. Some drugs were utilized from category D for treatment of chronic illnesses.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3966-5) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

2018

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“…1,2 Medications such as folic acid, vitamins, iron, and others may be needed to supplement mothers' diet or to manage co-morbid illness such as diabetes mellitus, malaria, urinary tract infection, hypertension, Human Immune-deficiency Virus (HIV) infection, or mental illness. 3,4 Rational medications use during pregnancy has always created a challenge in antenatal care due to the potential risk associated with use, both to the mother and the foetus. 5 Drug utilization studies have revealed that a high proportion of women use medications during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Medication use among pregnant women at a secondary health institution: utilisation patterns and predictors of quantity

Obadeji¹,

Obadeji²,

Bamidele³

et al. 2020

Afr H. Sci.

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Background: Despite the lack of adequate studies on the safety of drugs in pregnancy, surprisingly, available evidence shows that pregnant women still take large number of drugs. Objectives: The study aim was to determine drug utilization pattern and predictors of number of medications used by pregnant women. Methods: This was a cross-sectional survey of 369 pregnant women attending a secondary health facility. Data were collect- ed using interviewer-administered questionnaire. Descriptive and inferential statistics using the Chi-Square test were carried out with level of significance set at p<0.05. Results: Three hundred and sixty-nine women were interviewed. Their mean age was 27.7 years (SD± 4.78) and the mean number of pregnancies was 2.46 (SD± 1.34). On average, 2.62 medications were taken, with the lowest being 1 and the highest being 12 different medications during the course of pregnancy. Those who were on more than 2 medications were more likely to be older than 30 years, had lower education and with history of associated medical conditions. All participants were on one form of supplements or the other, nearly half had used antimalarials, 12.8%, 5.8% 2.4% were on antibiotics, anti-hypertensive and anti-retroviral medications respectively. All the medications prescribed were from category A, B, C, N, and none from category D and X. Conclusion: Varieties of medications were used during the course of pregnancy among this population, however, most of these drugs were still within safety profile. Keywords: Medications; pregnancy; pattern; predictors; co-morbidity.

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“…In general, the use of prescription medications and other over the counter drugs should be avoided during pregnancy. However, it is unlikely to avoid all drugs during pregnancy because this may put both the mother and fetus in danger from complications of untreated acute and chronic medical disorders such as epilepsy, diabetes mellitus, thyroid disorder, severe depression, hypertension, and bronchial asthma [4,5]. Besides, respiratory infections, headaches, constipation, nervousness, and other common complaints that occur during pregnancy may also need drug treatments.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have been conducted in various parts of developed [20][21][22][23][24] and developing countries [5,10,[25][26][27] to assess drug utilization patterns during pregnancy. Despite the limited information available on the safety and effectiveness of drugs in pregnancy, a large proportion of those studies reported that health care professionals prescribe and pregnant mothers consume a surprisingly large number of drugs.…”

Section: Introductionmentioning

confidence: 99%

Patterns and determinants of prescribed drug use among pregnant women in Adigrat general hospital, northern Ethiopia: a cross-sectional study

Alema

Semagn

Melesse

et al. 2020

BMC Pregnancy Childbirth

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Background A vigilant prescription of drugs during pregnancy can potentially safeguard the growing fetus from the deleterious effect of the drug while attempting to manage the mother’s health problems. There is a paucity of information about the drug utilization pattern in the area of investigation. Hence, this study was implemented to investigate the pattern of drug utilization and its associated factors among pregnant women in Adigrat general hospital, Northern Ethiopia. Methods An institution-based cross-sectional study was conducted among randomly selected 314 pregnant women who attended obstetrics-gynecology and antenatal care units of the hospital. Relevant data were retrieved from the pregnant women’s medical records and registration logbook. The drugs prescribed were categorized based on the United States Food and Drug Administration (US-FDA) fetal harm classification system. Data analysis was done using SPSS version 20 statistical software. Multivariate logistic regression was employed to analyze the association of the explanatory variables with the medication use, and p < 0.05 was declared statistically significant. Results The overall prescribed drug use in this study was found to be 87.7%. A considerable percentage of the study participants (41.4%) were prescribed with supplemental drugs (iron folate being the most prescribed drug) followed by antibiotics (23.4%) and analgesics (9.2%). According to the US-FDA drug’s risk classification, 42.5, 37, 13, and 7% of the drugs prescribed were from categories A, B, C, and D or X respectively. Prescribed drug use was more likely among pregnant women who completed primary [AOR = 5.34, 95% CI (1.53–18.6)] and secondary education [AOR = 4.1, 95% CI (1.16–14)], who had a history of chronic illness [AOR = 7.9, 95% CI (3.14–19.94)] and among multigravida women [AOR = 2.9, 95% CI (1.57 5.45)]. Conclusions The finding of this study revealed that a substantial proportion of pregnant women received drugs with potential harm to the mother and fetus. Reasonably, notifying health practitioners to rely on up-to-date treatment guidelines strictly is highly demanded. Moreover, counseling and educating pregnant women on the safe and appropriate use of medications during pregnancy are crucial to mitigate the burden that the mother and the growing fetus could face.

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Assessment of Drug Usage Pattern during Pregnancy at a Tertiary Care Teaching Hospital

Cited by 10 publications

References 9 publications

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

Medication use among pregnant women at a secondary health institution: utilisation patterns and predictors of quantity

Patterns and determinants of prescribed drug use among pregnant women in Adigrat general hospital, northern Ethiopia: a cross-sectional study

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