Assessment of dry eye in a GVHD murine model: Approximation through tear osmolarity measurement

Martínez-Carrasco, Rafael; Sánchez‐Abarca, Luis Ignacio; Nieto-Gómez, Cristina; García, Elisabet M. Rascón; Ramos, Teresa Lopes; Velasco, Almudena; Sánchez‐Guijo, Fermín; Aijón, José; Hernández-Galilea, Emiliano

doi:10.1016/j.exer.2016.11.004

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…At the basic research level, there are several ocular GVHD animal models [120][121][122][123] and several candidates that may be applicable for developing new therapies in the future. Heavy chain hyaluronan pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane and is known to exert anti-inflammatory and antifibrotic actions.…”

Section: Treatmentmentioning

confidence: 99%

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Ogawa

2018

Invest. Ophthalmol. Vis. Sci.

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I have reviewed available literature on dry eye related to Sjögren's syndrome (SS), non-Sjögren's syndrome (non-SS), and graft-versus-host disease (GVHD) to examine aqueous tear deficient dry eye as a subtype of dry eye. This section will focus on clinical studies regarding those subtypes of dry eye. I searched the PubMed database from 1990-2017 for discussion of clinical features, diagnostic criteria, and risk factors of SS, non-SS, and GVHD-related dry eye. In addition, therapeutic options for each subtype of dry eye are described. Although the clinical presentations of SS and chronic graft-versus-host disease (cGVHD) are similar, ocular surface fibrotic changes are characteristic of ocular GVHD but not SS-or non-SS-related dry eye. Recently, diagnostic criteria for each disease have been proposed and include the American College of Rheumatology/European League Against Rheumatism (ACR-EULAR) for SS and the International Chronic Ocular GVHD consensus criteria. Although there has been gradual progress, there are currently no specific therapies and few approved treatment options for these intractable diseases, including SS and GVHD. As judged by the findings, these subtypes of dry eye are different clinical entities from simple dry eye. Therefore, novel therapies, specific to these subtypes of dry eye, may be required in the future.

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Section: Treatmentmentioning

confidence: 99%

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Ogawa

2018

Invest. Ophthalmol. Vis. Sci.

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“…Dry eye disease (DED) is a very common disease, associated with high osmolarity of the tear film and mild inflammation at the surface of eye [ 1 ]. The surface of eye consists of meibomian glands (the special sebaceous glands located at the eyelid margin to produce the outer lipid layer of the tear film), accessory lacrimal glands, conjunctiva, cornea, the main lacrimal gland, and the connection between all these structures collectively forms a proper functioning unit.…”

Section: Introductionmentioning

confidence: 99%

Determination of Risk Factors and Treatment of Dry Eye Disease in Type 1 Diabetes Before Corneal Complications at Sindh Institute of Ophthalmology And Visual Sciences

Shujaat¹,

Jawed²,

Memon³

et al. 2017

TOOPHTJ

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Objective:The objective of this study was to assess and determine the risk factors and treatment of dry eye disease in type 1 diabetes before any ocular surface or corneal complication occurs. This study was conducted at Sindh Institute of Ophthalmology And Visual Sciences, Hyderabad, Pakistan.Methodology:Subjects and methods for observational study were undertaken at the Department of Ophthalmology Sindh Institute Of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Hundred confirmed cases of type 1 diabetes were included in the study by non probability convenience sampling. Tear film breakup time and schrimer test were carried out to determine dry eye disease. Data was collected by self-prepared questionnaire and entered and analyzed by using Statistical Program for Social Sciences (SPSS, version 20.0). The frequencies and percentage were recorded and any associations with predisposing factors were statistically analyzed by t test.Results:Out of hundred patients, 71 (71%) were found to have dry eyes (P<0.001). The mean age of the subject in this study was 50.97 years (range 30-70 years). Old age was related to high risk of dry eye disease (P<0.001). There was no big difference in the incidence of dry eyes in males and females. Long duration was found to be related with increased occurrence of dry eyes (P<0.001). We found higher values for abnormal tear film break up time than schirmer test values leading to increased occurrence of evaporative dry eyes.Conclusion:There is marked increase in frequency/ risk of developing dry eye disease in type 1 diabetes patients. Therefore, it is recommended to have periodic ophthalmic examination for type 1 diabetic patients.

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“…Devices than can measure tear osmolarity and MMP-9 level are likely to be more objective than previous tests. Tear hyperosmolarity was found to be significantly correlated with the pathophysiology and severity of immune-mediated DE, such as that in SS [17][18][19]. Levels of MMP-9, which are known to be increased in ocular injuries such as graft-versus-host-disease and laser surgery, are also elevated in the salivary and lacrimal glands of SS patients [20][21][22].…”

mentioning

confidence: 99%

Tear Osmolarity and Matrix Metallopeptidase-9 in Dry Eye Associated with Sjögren's Syndrome

Kook

Jin

et al. 2020

Korean J Ophthalmol

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Sjögren's syndrome (SS), with an estimated prevalence of 0.5% to 1.0% in the general population, is a chronic autoim-mune disease characterized by the production of autoantibodies, deposition of immune complexes, and infiltration of the musculoskeletal system, respiratory system, kidneys, nervous system, and exocrine glands with immune cells [1-5]. SS occurs predominately in middle-aged women and can lead to severe dry eye (DE) or dry mouth as it typically affects exocrine glands-mainly the lacrimal and salivary glands. In SS, tear production is reduced due to chronic autoim-Purpose: To evaluate the correlations between tear osmolarity and matrix metallopeptidase-9 (MMP-9) and dry eye (DE) indices in patients with DE associated with Sjögren's syndrome (SS). Methods: Sixty-three patients with DE associated with SS who underwent tear analysis were included. DE tests performed were ocular surface disease index, tear break-up time, Schirmer's test, ocular staining score, and tear osmolarity and MMP-9 tests. Correlations between tear osmolarity and DE indices, differences between patients with abnormal and normal tear osmolarity, and those between positive and negative MMP-9 patients were analyzed. Patients were classified into four groups according to tear osmolarity and MMP-9 results, and between-group differences were analyzed (group 1: abnormal tear osmolarity, MMP-9 positive; group 2: abnormal tear osmolarity, MMP-9 negative; group 3: normal tear osmolarity, MMP-9 positive; group 4: normal tear osmolarity, MMP-9 negative). Results: Mean age of patients was 54.2 ± 13.9 years, and 96.2% were female. Thirty-five patients had abnormal tear osmolarity and 40 patients were MMP-9 positive. DE indices differed between groups with abnormal and normal tear osmolarity (p < 0.01), but not between positive and negative MMP-9 groups. There were 22 patients in group 1, 13 in group 2, 18 in group 3, and 10 in group 4. Compared to group 4, tear break-up time was shorter in groups 1 (p < 0.01) and 2 (p = 0.02). Schirmer's test values in group 1 were lower than those in group 4 (p = 0.03). Ocular staining score was higher in groups 1 (p < 0.01) and 2 (p < 0.05) than in group 4. Conclusions: Tear osmolarity was correlated with ocular surface indices in DE associated with SS. Combination of tear osmolarity and MMP-9 test results may be helpful to determine the severity of DE associated with SS.

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Assessment of dry eye in a GVHD murine model: Approximation through tear osmolarity measurement

Cited by 12 publications

References 30 publications

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Determination of Risk Factors and Treatment of Dry Eye Disease in Type 1 Diabetes Before Corneal Complications at Sindh Institute of Ophthalmology And Visual Sciences

Tear Osmolarity and Matrix Metallopeptidase-9 in Dry Eye Associated with Sjögren's Syndrome

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