Assessment of Duodopa® effects on quality of life of patients with advanced Parkinson’s disease and their caregivers

Corallo, Francesco; Buono, Viviana Lo; Lorenzo, Giuseppe Di; Versaci, Roberta; Allone, Cettina; Palmeri, Rosanna; Bramantı, Placido; Marıno, Silvia

doi:10.1007/s00415-018-8951-3

Cited by 26 publications

(32 citation statements)

References 52 publications

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“…2 It has recently been reported that after 6 months of LCIG treatment there was a significant improvement of anxiety, depression, level of care burden and QoL, especially in the domains related to social life, 2908 vitality and mental health compared to baseline, even if no significant relationship was found between these factors and the burden. 17 In another study, a parallel trend between caregivers' QoL, depression, burden, sleep and patients' QoL, depression and sleep has been observed. 28 We found it noteworthy in our study, that although more than 50% of the patients had sleep disturbances and approximately one third of the patients had a feeling of depressed mood, the intensity of the caregiver's burden was mild or moderate.…”

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confidence: 86%

<p>Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden</p>

Modugno¹,

Antonini²,

Tessitore³

et al. 2020

NDT

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The aim of this study was to assess the burden and the quality of life (QoL) perceived by caregivers assisting advanced Parkinson's disease (PD) patients. Patients and Methods: Consecutive advanced PD patients treated with levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) or care as usual (CU) and their care partners were recruited during routine visits according to a cross-sectional design. Caregiver's distress was assessed by Zarit Burden Interview (ZBI) and a QoL survey to evaluate and understand the burden experienced by care partners during family and working activities. Results: A total of 126 patients (53 LCIG, 19 CSAI and 54 CU) and their care partners were enrolled. The ZBI score boxplot showed that LCIG and CU populations have a similar distribution (ZBI inter-quartile range [IQR] values respectively 18-42 for LCIG and 19-43 for CU group), while the CSAI group has a wider score range (IQR 16-52). Caregivers assisting patients in treatment with LCIG have more time to perform family or household duties (p=0.0022), or to engage in leisure activities (p=0.0073) compared to CU, while no difference was found when compared to CSAI group. Approximately 50% of the care partners showed mood changes in the last 6 months and LCIG and CSAI had less impact on caregiver's mood compared to CU. Patients treated with LCIG were more independent in taking a bath or shower without assistance and were more able to move and walk without assistance. Conclusion: Care partners of advanced PD patients treated with device-aided therapies have more time for their own life and a better perception of their QoL with a tendency to an improvement of mood compared with those of patients treated with CU.

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confidence: 86%

<p>Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden</p>

Modugno¹,

Antonini²,

Tessitore³

et al. 2020

NDT

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“…Specifically, mood, neuropsychiatric symptoms, sleep problems, fatigue, and pain were more severe in patients with 5-2-1 positive criteria and the percentage of patients with severe to very severe NMS burden was the double in this group compared to those patients with negative criteria. On the other hand, some studies have shown improvement in the caregiver status of patients with advanced PD after starting some second-line therapies [29,30]. An overburdened caregiver cares less which contributes to a worse QoL of the patient, so it is important to identify the problem and take action.…”

Section: Discussionmentioning

confidence: 99%

5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson’s Treatment

Santos‐García

Fonticoba

Castro

et al. 2020

Parkinson's Disease

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Objective. 5-(5 times oral levodopa tablet taken/day) 2-(2 hours of OFF time/day) 1-(1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson's disease (PD). e aim of the present study is to compare quality of life (QoL) in PD patients with "5-2-1 positive criteria" vs QoL in PD patients without "5-2-1 positive criteria" (defined as meeting ≥1 of the criteria). Methods. is is a cross-sectional, observational, monocenter study. ree different instruments were used to assess QoL: the 39-Item Parkinson's Disease Quality of Life Questionnaire Summary Index Score (PDQ-39SI); a subjective rating of perceived QoL (PQ-10); and the EUROHIS-QOL 8-Item Index (EUROHIS-QOL8). Results. From a cohort of 102 PD patients (65.4 ± 8.2 years old, 53.9% males; disease duration 4.7 ± 4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6 ± 14 vs 12.1 ± 9.2; p < 0.0001) and global QoL (PQ-10, 6.1 ± 2 vs 7.1 ± 1.3; p � 0.007; EUROHIS-QOL8, 3.5 ± 0.5 vs 3.7 ± 0.4; p � 0.034) were worse in patients with 5-2-1 positive criteria. Moreover, nonmotor symptoms burden (Non-Motor Symptoms Scale total score, 64.8 ± 44.8 vs 39.4 ± 35.1; p < 0.0001) and autonomy for activities of daily living (ADLS scale, 73.5 ± 13.1 vs 89.2 ± 9.3; p < 0.0001) were worse in patients with 5-2-1 positive criteria. Patient's principal caregiver's strain (Caregiver Stain Index, 4.3 ± 3 vs 1.5 ± 1.6; p < 0.0001), burden (Zarit Caregiver Burden Inventory, 28.4 ± 12.5 vs 10.9 ± 9.8; p < 0.0001), and mood (Beck Depression Inventory II, 12.2 ± 7.2 vs 6.2 ± 6.1; p < 0.0001) were worse in patients with 5-2-1 positive criteria as well. Conclusions. QoL is worse in patients meeting ≥1 of the 5-2-1 criteria. is group of patients and their caregivers are more affected as a whole. ese criteria could be useful for identifying patients in which it is necessary to optimize Parkinson's treatment.

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“…Hinsichtlich der Bedeutung medikamentöser und invasiver Therapien auf die Betreuungsbelastung finden sich in der Literatur einerseits der Faktor Dosis der dopaminergen Therapie als Ausdruck der Krankheitsdauer und des Schweregrades der motorischen Symptomatik des Pfleglings als ein Belastungsfaktor [12,33,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50], andererseits einige medikamentöse Therapien, wie die Levodopa/Carbidopa intestinale Geltherapie (Duodopa), zu der in nichtkontrollierten Studien teilweise positive Effekte auf die Betreuungsbelastung festgestellt wurden [38,39] und die Palliativ-Betreuung [19,20,32]. Außerdem wurde in kontrollierten Therapiestudien mit Memantin und Donepezil bei Personen mit Parkinson-Demenz und Demenz mit Lewy-Körperchen sowie mit Rivastigmin bei apathischen depressions-und demenzfreien Parkinson-Pat.…”

Section: Literaturrecherche Und Analyseunclassified

Belastungen in der Betreuung von Parkinson-Patientinnen und - Patienten

Ransmayr¹

2020

Fortschr Neurol Psychiatr

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ZusammenfassungPatientinnen und Patienten (Pat.) mit Parkinson-Krankheit bedürfen mit zunehmender Krankheitsdauer und Schweregrad persönlicher Betreuung, die meist von weiblichen Angehörigen gewährleistet wird. Die Belastungen für pflegende Angehörige resultieren einerseits aus den motorischen Beeinträchtigungen der Pat., andererseits von neurokognitiven und neuropsychiatrischen Symptomen sowie Verhaltensstörungen, Störungen des autonomen Nervensystems, der Miktion, des Schlafes und der Selbstständigkeit. Gesundheitliche Probleme der Betreuungsperson, u. a. Depression und Angst, emotionale Probleme mit dem Pflegling, Beeinträchtigung des Schlafs, sowie Einschränkungen in persönlichen Anliegen, Beruf, Familie, Freizeitgestaltung, sozialen Aktivitäten, finanzielle Einbußen und mangelhafte soziale Unterstützung stellen weitere Belastungsfaktoren dar. Personen mit dem Risiko einer erheblichen Betreuungsbelastung sind frühzeitig zu identifizieren, um ihnen Informationen über die Krankheit und Unterstützungsmöglichkeiten sowie entsprechende personelle, psychologische und finanzielle Unterstützung zukommen zu lassen.

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Assessment of Duodopa® effects on quality of life of patients with advanced Parkinson’s disease and their caregivers

Cited by 26 publications

References 52 publications

<p>Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden</p>

<p>Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden</p>

5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson’s Treatment

Belastungen in der Betreuung von Parkinson-Patientinnen und - Patienten

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