Assessment of early lung disease in young children with CF: A comparison between pressure‐controlled and free‐breathing chest computed tomography

Oudraad, Merel C. J.; Kuo, Wieying; Rosenow, Tim; Andrinopoulou, E.-R.; Stick, Stephen M.; Tiddens, Harm A.W.M.

doi:10.1002/ppul.24702

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…Given the speed of operation, CT scanning can be performed without anaesthesia, thus avoiding cumbersome logistics and anaesthetic recovery times [32,34,37,147]. Thus, CT appears to be higher-yielding and easier to perform than MRI for cross-sectional imaging in preschool patients with a new diagnosis of CF, especially when performed in uncooperative patients [32,[146][147][148]162 Follow-up CR versus CT Despite the absence of strong supporting evidence in the literature, CR remains the most frequently used imaging modality for lung disease monitoring in several specialist centres; this is due to its ready availability and low cost, and the decades-long use of this technique by CF clinicians during routine follow-up. However, the sensitivity of CR is poor, and inter-observer variability between radiologists is high, even when combined with adequate scoring systems [47,48,50].…”

Section: First Diagnosismentioning

confidence: 99%

State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” (MAESTRO) consortium

et al. 2022

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ObjectiveImaging represents an important noninvasive means to assess cystic fibrosis (CF) lung disease, which remains the main cause of morbidity and mortality in CF patients. While the development of new imaging techniques has revolutionised clinical practice, advances have posed diagnostic and monitoring challenges. The authors aim to summarise these challenges and make evidence-based recommendations regarding imaging assessment for both clinicians and radiologists.Study designA committee of 21 experts in CF from the 10 largest specialist centres in Italy was convened, including a radiologist and a pulmonologist from each centre, with the overall aim of developing clear and actionable recommendations for lung imaging in CF. An a priori threshold of at least 80% of the votes was required for acceptance of each statement of recommendation.ResultsAfter a systematic review of the relevant literature, the committee convened to evaluate 167 articles. Following five RAND conferences, consensus statements were developed by an executive subcommittee. The entire consensus committee voted and approved 28 main statements.ConclusionsThere is a need for international guidelines regarding the appropriate timing and selection of imaging modality for patients with CF lung disease; timing and selection depends upon the clinical scenario, the patient's age, lung function and type of treatment. Despite its ubiquity, the use of the chest radiograph remains controversial. Both computed tomography and magnetic resonance imaging should be routinely used to monitor CF lung disease. Future studies should focus on imaging protocol harmonisation both for computed tomography and for magnetic resonance imaging. The introduction of artificial intelligence imaging analysis may further revolutionise clinical practice by providing fast and reliable quantitative outcomes to assess disease status. To date, there is no evidence supporting the use of lung ultrasound to monitor CF lung disease.

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Section: First Diagnosismentioning

confidence: 99%

State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” (MAESTRO) consortium

et al. 2022

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“…Given the speed of the latest generation of CT scanners, the entire chest can be scanned in less than a second. For this reason, CT scanning can be performed without anaesthesia, thus avoiding cumbersome logistics and anaesthetic recovery times [ 20 , 21 ]. When needed, young children can be immobilised in a vacuum mattress, providing consistent diagnostic image quality (Fig.…”

Section: Clinical Scenario and Imaging Protocolsmentioning

confidence: 99%

Chest radiography and computed tomography imaging in cystic fibrosis: current challenges and new perspectives

et al. 2022

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Imaging plays a pivotal role in the noninvasive assessment of cystic fibrosis (CF)-related lung damage, which remains the main cause of morbidity and mortality in children with CF. The development of new imaging techniques has significantly changed clinical practice, and advances in therapies have posed diagnostic and monitoring challenges. The authors summarise these challenges and offer new perspectives in the use of imaging for children with CF for both clinicians and radiologists. This article focuses on chest radiography and CT, which are the two main radiologic techniques used in most cystic fibrosis centres. Advantages and disadvantages of radiography and CT for imaging in CF are described, with attention to new developments in these techniques, such as the use of artificial intelligence (AI) image analysis strategies to improve the sensitivity of radiography and CT and the introduction of the photon-counting detector CT scanner to increase spatial resolution at no dose expense.

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“…Changes in CT scan modality between pressure‐controlled CT under general anesthesia to multi‐slice CT during free breathing without anesthesia were compared using findings from AREST‐CF cohort 49 . Comparison of this young cohort (median age around 4 years) used the PRAGMA‐CF score.…”

Section: Introductionmentioning

confidence: 99%

Cystic fibrosis year in review 2020: Section 2 pulmonary disease, infections, and inflammation

Antos

Savant

2021

Pediatric Pulmonology

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The outlook for those with cystic fibrosis (CF) has never been brighter with ever increasing life expectancy and the approval of the highly effective CFTR modulators, such as elexacaftor/tezacaftor/ivacaftor. With that being said, the progressive pulmonary decline and importance of lung health, infection, and inflammation in CF remains. This review is the second part in a three‐part CF Year in Review 2020. Part one focused on the literature related to CFTR modulators while part three will feature the multisystem effects related to CF. This review focuses on articles from Pediatric Pulmonology, including articles from other journals that are of particular interest to clinicians. Herein, we highlight studies published during 2020 related to CF pulmonary disease, infection, treatment, and diagnostics.

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Assessment of early lung disease in young children with CF: A comparison between pressure‐controlled and free‐breathing chest computed tomography

Cited by 11 publications

References 28 publications

State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” (MAESTRO) consortium

State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” (MAESTRO) consortium

Chest radiography and computed tomography imaging in cystic fibrosis: current challenges and new perspectives

Cystic fibrosis year in review 2020: Section 2 pulmonary disease, infections, and inflammation

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