Assessment of Early Markers of Cardiovascular Risk in Polycystic Ovary Syndrome

Alexandraki, Krystallenia; Kandaraki, Eleni; Poulia, Kalliopi-Anna; Piperi, Christina; Papadimitriou, Eirini; Παπαϊωάννου, Θεόδωρος

doi:10.17925/ee.2021.17.1.37

Cited by 11 publications

(9 citation statements)

References 283 publications

(294 reference statements)

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“…Treatment with a PPARƳ agonist inhibits LPS-induced endothelial inflammation by reducing IL-6, VCAM, TNF-α, and mRNA expression [ 96 ]. In turn, this reduces the production of inflammatory mediators, adhesion molecules, and atherosclerosis in endothelial cells [ 97 , 98 ]. Similarly, a model of diabetic nephropathy suggested that treatment with pioglitazone reduces glomerular sclerosis, fibrosis, and hypertrophy by lowering ICAM-1, E-selectin, and albuminuria [ 98 , 99 ].…”

Section: Discussionmentioning

confidence: 99%

“…In turn, this reduces the production of inflammatory mediators, adhesion molecules, and atherosclerosis in endothelial cells [ 97 , 98 ]. Similarly, a model of diabetic nephropathy suggested that treatment with pioglitazone reduces glomerular sclerosis, fibrosis, and hypertrophy by lowering ICAM-1, E-selectin, and albuminuria [ 98 , 99 ]. However, a study on women with polycystic ovarian syndrome found that pioglitazone treatment for insulin resistance dramatically improved endothelial-independent function, adipokines, and ET-1 [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

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Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

et al. 2022

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Type 2 diabetes mellitus (T2D) is a world wild health care issue marked by insulin resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction, increasing the risk of cardiovascular complications. Peroxisome proliferator-activated receptor PPAR) agonists have therapeutically mitigated hyperlipidemia and hyperglycemia in T2D patients. Therefore, we aimed to experimentally investigate the efficacy of newly designed synthetic PPARα/Ƴ partial agonists on a High-Fat Diet (HFD)/streptozotocin (STZ)-induced T2D. Female Wistar rats (200 ± 25 g body weight) were divided into four groups. The experimental groups were fed the HFD for three consecutive weeks before STZ injection (45 mg/kg/i.p) to induce T2D. Standard reference PPARƳ agonist pioglitazone and the partial synthetic PPARƳ (PIO; 20 mg/kg/BW, orally) were administered orally for 2 weeks after 72 h of STZ injection. The aorta tissue was isolated for biological ELISA, qRT-PCR, and Western blotting investigations for vascular inflammatory endothelial mediators endothelin-1 (ET-1), intracellular adhesion molecule 1 (ICAM-1), E-selectin, and anti-inflammatory vasoactive intestinal polypeptide (VIP), as well as microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR, endothelial Nitric Oxide Synthase (eNOS) immunohistochemical staining all are coupled with and histopathological examination. Our results revealed that HFD/STZ-induced T2D increased fasting blood glucose, ET-1, ICAM-1, E-selectin, and VIP levels, while decreasing the expression of both microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR phosphorylation. In contrast, the partial synthetic PPARƳ derivative evidenced a vascular alteration significantly more than reference PIO via decreasing (ET-1), ICAM-1, E-selectin, and VIP, along with increased expression of microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR. In conclusion, the partial synthetic PPARƳ derivative significantly affected HFD/STZ-induced T2D with vascular complications in the rat aorta.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

et al. 2022

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“…Barber et al, have shown that insulin resistance (IR) is a common abnormality in 50-90% of PCOS individuals (11). In women with PCOS, IR appears to be related to abnormal insulin-independent serine phosphorylation of the beta-subunit of insulin receptor and insulin receptor substrate 1 (IRS1) (2). PCOS women have decreased uptake of insulin by liver with consequent hyperinsulinemia (7).…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence varies widely based on the criteria used for diagnosis of PCOS (1). In 1996, the prevalence was found to be 6-8% (2). The prevalence has been increasing worldwide due increase in individuals with obesity and diabetes mellitus (3).…”

Section: Introductionmentioning

confidence: 99%

“…Presence of type 2 diabetes mellitus (T2DM), hypertension, obesity and dyslipidemia lead to metabolic syndrome (MetS) in PCOS individuals. Thus around 40% individuals are at risk for atherosclerosis and myocardial infarction (2). Women with PCOS vary in the clinical presentations; there can be mild irregularity in menstruation, menorrhagia, amenorrhea, infertility, features of hyperandrogenism and IR.…”

Section: Introductionmentioning

confidence: 99%

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Association of prolactin and insulin with obesity in women with polycystic ovarian syndrome

Lavanya¹,

Palaniappan²,

V.M.³

et al. 2022

Biomedicine

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Introduction and Aim: Polycystic Ovarian Syndrome (PCOS) manifests with menstrual irregularities, infertility, galactorrhoea and hirsutism. Hormonal irregularities are found to be the pathogenesis behind PCOS. The study was aimed to evaluate whether obesity is associated with serum prolactin and insulin levels in PCOS women. Materials and Methods: This case control study was conducted in a tertiary care hospital in Chennai. Control group included 30 apparently healthy women and cases included 30 PCOS patients, diagnosis based on Rotterdam criteria. The individuals were of 20-40 years of age in both the groups. The serum prolactin and insulin were analysed by ELISA. The obtained data were checked for normality of distribution and subjected to statistical analysis. Receiver Operating Characteristics (ROC) curve was done. Statistical analyses were performed using SPSS version 16.0. P less than 0.05 was considered statistically significant. Results: The median and interquartile range (IQR) of serum insulin were 11.5 (1.8-70) and 5 (1.8-44) mIU/L in cases and controls respectively. The cut-off level of insulin was 7.0 mIU/L. The median and IQR of serum prolactin were 12.5 (4.5-53.0) and 12 (3.5-20) ng/mL in cases and controls respectively. BMI was positively correlated with age of the participants and prolactin. Conclusion: PCOS is prevalent among obese reproductive individuals. Insulin was markedly elevated in PCOS individuals. Insulin resistance alters levels of luteinizing hormone and sex hormone binging globulins. Hyperprolactinemia is associated with anovulation or oligoovulation, galactorrhoea and hirsutism. In obese PCOS women, prolactin and insulin could be diagnostic markers of PCOS.

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Polycystic Ovarian Syndrome Treated by Homoeopathy: An Evidence-Based Case Report

Nahar,

Shil

2024

Homœopathic Links

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Background Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive women. Cardinal manifestations of PCOS include hyperandrogenism, oligo/anovulation and/or polycystic ovarian morphology. Affected women often display notable metabolic co-morbidities. Plenty of evidence on PCOS favouring homoeopathy is available in the literature. In this case, also individualised medicine portrayed a favourable response within a short span of time. Case Summary A case of PCOS with the complaint of irregular, delayed menses, acne on the face and dark pigmentation on the neck for the last 3 years is presented here. The outcome was assessed by using two validated measurement scales. After 4 months of follow-up, the case was markedly improved on the Outcome Related to Impact on Daily Living (ORIDL) scale (+4) as per the patient's perspective. Clinical improvement was correlated with objective evidence from the ultrasonography report. Modified Naranjo criteria for Homeopathy (MONARCH) score recorded at the final visit (+8 on the ‘−6 to 13’ scale) is suggestive of a high likelihood of improvement by homoeopathic intervention. Conclusion The case report presented here has produced significant evidence of the effect of individualised homoeopathic medicine in the treatment of PCOS within a short time.

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Assessment of Early Markers of Cardiovascular Risk in Polycystic Ovary Syndrome

Cited by 11 publications

References 283 publications

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

Association of prolactin and insulin with obesity in women with polycystic ovarian syndrome

Polycystic Ovarian Syndrome Treated by Homoeopathy: An Evidence-Based Case Report

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