Assessment of effect of propofol and ketamine in electroconvulsive therapy anesthesia

Abstract

Background: Ketamine is in clinical use since 1970. It is a unique intravenous (IV) anesthetic that produces a wide spectrum of pharmacological effects including sedation, catalepsy, somatic analgesia, bronchodilation, and sympathetic nervous system stimulation. Materials and Methods: The present study was conducted in the Department of Anesthesiology of MGM Medical College, Navi Mumbai. 100 patients who were scheduled for ECT treatment were enrolled. The study population was randomly assigned to receive one of three anesthetic agents (Ketamine, Propofol, or Ketofol). After premedication with intravenous atropine sulfate (0.25 mg), propofol (10 mg/ml), ketamine (10 mg/ml), or ketofol was administered slowly (20 mg/10 s) until the patient no longer responded to his/her name being called loudly and showed loss of the eyelash reflex. Results: We found that both ketamine and Ketofol have an increased mean seizure duration compared to propofol. Conclusion:We found that both Ketamine and Ketofol have an increased mean seizure duration compared to propofol.