Assessment of efficacy of micronized progesterone by vaginal route for prevention of preterm labour

Deshpande, Hemant; Sharma, Monika; Reyaz, Afifa; Madkar, Chandrakant S.; Huzurbazar, Sarika

doi:10.33545/gynae.2019.v3.i6e.429

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The results obtained show than the use of progeterones both orally and vaginally, are comparable to parity. This is similar to the studies of Mostafa AH [11] and Deshpande H et al [12] . Mostafa AH 11 study found mean age for oral group was (28.7±7.2) and for the vaginal group was (28.1±8) which showed insignificant difference statistically.…”

Section: Comparison Of Birth Weight Of Neonates Between Groupssupporting

confidence: 92%

“…Mostafa AH 11 study found mean age for oral group was (28.7±7.2) and for the vaginal group was (28.1±8) which showed insignificant difference statistically. Deshpande H et al [12] prospective study assessing efficacy of natural micronized progesterone by vaginal route in prevention of PTL found maternal age was 28±4.3 in progesterone group versus 28.2±4.5 in placebo group. The mean gestational age of patients in OMP group and VMP group was 31.37 ± 1.94 weeks and 33.49 ± 2.49 weeks respectively.…”

Section: Comparison Of Birth Weight Of Neonates Between Groupsmentioning

confidence: 99%

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Comparative study of oral and vaginal natural micronized progesterone 300mg in preventing preterm labor in semi urban population

Das¹,

G²,

Priya³

et al. 2022

Int. J. Clin. Obstet. Gynaecol.

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Preterm deliveries is the major contributors of neonatal mortalities and under 5 age group morbidities. Excessive use of Progesterone and its supplements, antenatal steroidal cover and tocolysis prevents this. In this study, there has been made an attempt to study the perinatal outcome of both mother and neonate revolving around premature deliveries by using two different routes for progesterone administration. A prospective study was done on randomly selected 300 patients who complained of pain abdomen after 24 weeks of pregnancy, and were followed up till delivery after administration of progesterone, after dividing into 2 separate groups. This leads to collection of data for interpretation of association of variation in various parameters with relation to use of different routes for micronized progesterone. When compared, users of Oral micronized progesterone (OMP) presented at 31.37±1.94 weeks for delivery and that of Vaginal micronized progesterone (VMP) presented at 33.49±2.49 weeks of gestation. 78.7% neonates of Oral group were asymptomatic at birth than those 90.7% of vaginal neonates. Incidence of neonatal morbidity, like signs of birth asphyxia (16.7% vs 3.3%), mean APGAR Score of 1 min (7.77±2.11 vs. 8.07±1.63), mean birth weight (2.89±0.67 vs. 3.19±0.61), NICU admission (13.3% vs 3.3%) were found to be higher in Oral group than Vaginal group. Administration of Vaginal micronized progesterone helps in reduction of preterm labor and the rate of neonatal NICU admissions, neonatal mortality and morbidity as compared to oral micronized progesterone. Vaginal progesterone surpasses the first pass metabolism explaining the better outcome of the vaginal in preventing preterm labor.

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Section: Comparison Of Birth Weight Of Neonates Between Groupssupporting

confidence: 92%

Section: Comparison Of Birth Weight Of Neonates Between Groupsmentioning

confidence: 99%

Comparative study of oral and vaginal natural micronized progesterone 300mg in preventing preterm labor in semi urban population

Das¹,

G²,

Priya³

et al. 2022

Int. J. Clin. Obstet. Gynaecol.

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show abstract

“…5 When administered through vagina, however, it avoids the first-pass effect by the liver, is absorbed quickly, has increased bioavailability, directly affects the uterus, and is maintained in a high concentration in the serum. 6 Vaginal progesterone gel is administered through a specific applicator and a dose of 90 mg was used in all published studies. Vaginal progesterone suppository is inserted in the vagina with clean hands or plastic gloves.…”

Section: Introductionmentioning

confidence: 99%

Assessment Of Oral And Vaginal Natural Micronised Progesterone In Preventing Preterm Labor

2022

pnr

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Background: Preterm birth is an essentially rising global problem, however more than 60% of those occur in South Asia and Sub-Saharan Africa. The present study was conducted to compare oral and vaginal natural micronised progesterone 300 mg in preventing preterm labor.Materials & Methods: 80 pregnant women with gestational age between >24 week to <36 weekswere divided into 2 groups of 40 each. Group I patients were administered oral micronized progesterone 300 mg and group II were administered vaginal micronized progesterone. APGAR scoreat 5 minutes and birthweight were recorded. Number of neonates who required NICU admission were noted.Results: Gestational age 24-28 weeks had 10 patients in group I and 12 in group II, 29-32 weeks had 24 in group I and 20 in group II and 32-36 weeks had 6 in group I and 8 in group II. Perinatal outcome was asymptomatic at birth seen in 30 and 34, meconium aspiration syndrome in 1 and 2, birth asphyxia in 5 and 1, neonatal sepsis in 2 and 1 and hypoxemic ischaemic encephalopathyin 2 and 1 in group I and II respectively. The difference was significant (P< 0.05).NICU admission was seen in 4 in group I and 2 in group II, APGAR score at 1 minute was 7.25 in group I and 8.15 in group II and at 5 minutes was 7.85 in group I and 8.69 in group II. The mean birth weight<2.5 kgs was seen in 11 and 4, 2.5-3 Kgs in 15 and 11 and >3 kgs in 14 and 25 in group I and II respectively. The difference was significant (P< 0.05). Conclusion:Vaginal mode of administration is considered more efficaciousas compared to oral progesterone. It plays a vital role in the reduction of pre-term labor, reduces the rate of neonatal NICU admissions, neonatal mortality and morbidity.

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Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis

Conde-Agudelo

Romero

2022

American Journal of Obstetrics and Gynecology

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Assessment of efficacy of micronized progesterone by vaginal route for prevention of preterm labour

Cited by 3 publications

References 20 publications

Comparative study of oral and vaginal natural micronized progesterone 300mg in preventing preterm labor in semi urban population

Comparative study of oral and vaginal natural micronized progesterone 300mg in preventing preterm labor in semi urban population

Assessment Of Oral And Vaginal Natural Micronised Progesterone In Preventing Preterm Labor

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis

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