Assessment of encrustation and physicochemical properties of poly(lactide‐glycolide) <scp>‐</scp> Papaverine hydrochloride coating on ureteral <scp>double‐J</scp> stents after long‐term flow of artificial urine

Antonowicz, Magdalena; Szewczenko, Janusz; Kajzer, Anita; Kajzer, W.; Jaworska, Joanna; Jelonek, Katarzyna; Karpeta-Jarząbek, Paulina; Bryniarski, Piotr; Krzywiecki, Maciej; Grządziel, Lucyna; Swinarew, Andrzej; Nakonieczny, Damian S.; Kasperczyk, Janusz

doi:10.1002/jbm.b.34913

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Soon afterwards, they investigated the impact of artificial urine on the physical and chemical properties of PLGA+PAP-coated stent tubes, building upon the foundation of previous studies on the stent tubes ( Antonowicz et al, 2022 ). The study showed that applying PAP coating increased surface hydrophilicity, which could make stent implantation easier.…”

Section: Future Clinical Applications Of Busmentioning

confidence: 99%

Recent development and future application of biodegradable ureteral stents

Hu,

Hou,

Huang

et al. 2024

Front. Bioeng. Biotechnol.

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Ureteral stenting is a common clinical procedure for the treatment of upper urinary tract disorders, including conditions such as urinary tract infections, tumors, stones, and inflammation. Maintaining normal renal function by preventing and treating ureteral obstruction is the primary goal of this procedure. However, the use of ureteral stents is associated with adverse effects, including surface crusting, bacterial adhesion, and lower urinary tract symptoms (LUTS) after implantation. Recognizing the need to reduce the complications associated with permanent ureteral stent placement, there is a growing interest among both physicians and patients in the use of biodegradable ureteral stents (BUS). The evolution of stent materials and the exploration of different stent coatings have given these devices different roles tailored to different clinical needs, including anticolithic, antibacterial, antitumor, antinociceptive, and others. This review examines recent advances in BUS within the last 5 years, providing an in-depth analysis of their characteristics and performance. In addition, we present prospective insights into the future applications of BUS in clinical settings.

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Section: Future Clinical Applications Of Busmentioning

confidence: 99%

Recent development and future application of biodegradable ureteral stents

Hu,

Hou,

Huang

et al. 2024

Front. Bioeng. Biotechnol.

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“…[ 1 ] At present, the most common USs are made of hydrophobic polyurethane or silicone polymers. [ 2 ] Reportedly, over 1.5 million USs are used worldwide every year, but more than 80% of patients normally suffer from the stent‐associated complications of bacterial infection and encrustation. [ 3 ] In the clinic, biofilm formation caused by the adhesion of urinary proteins, crystals and bacteria on the hydrophobic US surface is the main underlying cause of urinary tract infections (UTIs) and encrustation.…”

Section: Introductionmentioning

confidence: 99%

Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

Li,

Tang,

Peng

et al. 2023

Adv Funct Materials

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Hydrophilic lubricant coatings with antifouling properties are commercially applied to urological devices, such as ureteral stents (USs), to inhibit biofilm formation and reduce the likelihood of infectious encrustation. However, their long‐term effectiveness is limited due to the lack of active and precise antibacterial activity. Herein, this work reports a hydrophilic lubricant (defined as SA‐PU/PVP) coating with smart urease‐responsive antibiotic release functionality, achieved by incorporating the antibiotic sulfanilamide‐conjugated polyurethane (SA‐PU) polymers into a commercial lubricant coating agent containing hydrophilic polyvinylpyrrolidone (PVP). During the initial implantation period, the hydrophilic PVP chains rapidly absorb urine on the coating interface, forming a lubricating layer with the desired antifouling activities that reduce the attachment of host proteins, bacteria, and urate crystals by over 90%. As time progresses and the bacteria proliferates and produces urease, the urease enzymatically degrades the urea linkages in the SA‐PU/PVP coating, actively releasing SA antibiotics on demand to prevent biofilm formation and encrustation. Benefiting from this synergistic antifouling and smart antibacterial activities, the SA‐PU/PVP‐coated US exhibits superior performance in preventing infectious encrustation in a porcine model over a 7‐week period, surpassing the effectiveness of a commercial hydrophilic lubricant US. This coating strategy offers a practical solution for inhibiting urological device‐associated complications.

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“…20 However, the ends of this type of ureteral stent have a relatively large degree of curling, which causes patient discomfort and can easily cause kidney or bladder irritation. 21,22 Antonowicz et al 23 examined the impact of a biodegradable coating, containing an active diastolic substance, on the physical and chemical properties of ureteral stents used in the treatment of the upper urinary tract. The surface of PU double-J stents was coated with poly(lactide-glycolide) 85/15 loaded with diastolic papaverine hydrochloride, which has a relaxing effect on smooth muscle cells and decreases the patient's discomfort due to the stent implantation.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a novel braided biodegradable double‐J ureteral stent

Cui

Zhang

Gao

et al. 2022

Polymers for Advanced Techs

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Ureteral stents in current clinical use are non-degradable and have a large degree of curling at the ends. This end curling can cause discomfort to patients as well as renal or bladder irritation. In this study, a braided degradable ureteral stent was designed and characterized to eliminate these problems. Eight-, 12-, and 16-strand poly(lactide-co-ε-caprolactone) (PLCL) monofilament-braided degradable ureteral stents were prepared, and their tensile performance, radial support performance, in vitro degradation, fixation performance, bending resistance performance, and drainage performance were tested. Compared with the commonly used polyurethane (PU) stent, the tensile strengths of the three types of PLCL stents were higher, with the 12-strand monofilament-braided stent exhibiting the highest tensile strength ($508.06 MPa). In terms of radial support, the three PLCL stents meet clinical requirements. After repeated crimping-rebounding of the braided stent, the support force recovery rate of the 12-strand monofilament-braided stent was the best, reaching 92%. In vitro degradation results showed that the 12-strand stent still maintained good radial support after 8 weeks. The fixation strength of a 12-strand monofilament-braided stent with a single loop on the J-shaped end meets clinical requirements. Even after repeated bending, the 12-strand monofilament-braided stent can maintain the stability of the structure with excellent drainage performance.

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Assessment of encrustation and physicochemical properties of poly(lactide‐glycolide) ‐ Papaverine hydrochloride coating on ureteral double‐J stents after long‐term flow of artificial urine

Cited by 5 publications

References 43 publications

Recent development and future application of biodegradable ureteral stents

Recent development and future application of biodegradable ureteral stents

Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

Design and characterization of a novel braided biodegradable double‐J ureteral stent

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