Assessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalate

Park, Joonwoo; Park, Choa; Gye, Myung Chan; Lee, Youngjoo

doi:10.1016/j.envres.2019.02.001

Cited by 41 publications

(25 citation statements)

References 34 publications

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“…Bisphenol A (BPA) is a recognised environmental toxicant and one of the endocrine‐disrupting chemicals (EDCs), which is widely utilised as a monomer to manufacture various plastic products including food containers and dental sealants (Park et al., 2019; Wang, Liu, et al., ) and thus very easily leached out from these, into foodstuffs and beverages (Negev et al., 2018). Further, it gets hydrolysed by heat or extreme pH that poses a potential risk of exposure to humans and other animals (Vandenberg et al., 2007).…”

Section: Introductionmentioning

confidence: 99%

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

et al. 2021

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Being a vital micronutrient, along with a trace element, selenium (Se) protects the cells from oxidative stress (OS) in the form of selenoproteins. Bisphenol A (BPA) is a xeno‐oestrogenic compound that adversely affects the spermatogenesis process by inducing oxidative stress, which ultimately leads to male infertility. Therefore, it is hypothesised that Se could protect against BPA‐induced OS, and further germ cell death by modifying mitogen‐activated protein kinase (MAPK) signalling. Male Balb/c mice were divided into four groups: Group I (C) (0.2 ppm Se), Group II (Se) (0.5 ppm Se), Group III (BPA) (0.2 ppm Se, and BPA = 1 mg/kg orally) and Group IV (Se + BPA) (0.5 ppm Se, and BPA = 1 mg/kg bodyweight orally). Results indicated that BPA‐treated animals demonstrated a marked decrease in antioxidant enzyme activities (superoxide dismutase, catalase, redox ratio), a marked elevation in the expressions of stress‐activated kinases (c‐Jun NH2‐terminal kinase (JNK), extracellular signal‐regulated kinase (ERK) and p38) and the expressions of pro‐apoptotic markers (caspase‐9, caspase‐8 and caspase‐3). However, Se supplementation considerably restored the antioxidant enzyme activities and lowered the expressions of stress‐activated kinases, which further down‐regulated the apoptosis. Thus, Se supplementation demonstrated to be effective against BPA provoked testicular damage.

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Section: Introductionmentioning

confidence: 99%

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

et al. 2021

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“…Phthalates are easily released into the environment during their manufacture, use, or disposal since they are not covalently bound to the plastic [ 6 , 7 ], and, consequently, could be absorbed by the human body through different routes of exposure [ 8 ]. They can bind to molecular targets in the body and interfere with hormonal homeostasis [ 2 , 9 ], leading to different disorders in fetuses, infants, children, and adults [ 10 , 11 ], thus being considered as endocrine-disrupting compounds (EDCs). In addition, a common feature of endocrine disruptors is that they do not have a typical dose-response curve, that is, the increase in concentration does not correspond to the increase in their effect, as they present a non-monotonic curve [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phthalates Implications in the Cardiovascular System

Mariana

Cairrão

2020

JCDD

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Today’s sedentary lifestyle and eating habits have been implicated as some of the causes of the increased incidence of several diseases, including cancer and cardiovascular diseases. However, environmental pollutants have also been identified as another possible cause for this increase in recent decades. The constant human exposure to plastics has been raising attention regarding human health, particularly when it comes to phthalates. These are plasticizers used in the manufacture of industrial and consumer products, such as PVC (Polyvinyl Chloride) plastics and personal care products, with endocrine-disrupting properties, as they can bind molecular targets in the body and interfere with hormonal function. Since these compounds are not covalently bound to the plastic, they are easily released into the environment during their manufacture, use, or disposal, leading to increased human exposure and enhancing health risks. In fact, some studies have related phthalate exposure with cardiovascular health, having already shown a positive association with the development of hypertension and atherosclerosis in adults and some cardiometabolic risk factors in children and adolescents. Therefore, the main purpose of this review is to present and relate the most recent studies concerning the implications of phthalates effects on the cardiovascular system.

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“…Another study also indicated that ATEC has no effects on estrogen or antiestrogen activity or steroidogenesis. These reports suggest that ATEC may not have endocrine-disrupting activities [10]. Therefore, ATEC is considered relatively safe on the basis of the toxicological data published thus far.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Metabolism of Acetyl Triethyl Citrate, a Water-Soluble Plasticizer for Pharmaceutical Polymers in Rats

Kim

Rehman

et al. 2019

Pharmaceutics

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Acetyl triethyl citrate (ATEC) is a water-soluble plasticizer used in pharmaceutical plasticized polymers. In this study, the pharmacokinetics and metabolism of ATEC were investigated using liquid chromatography–tandem mass spectrometry (LC–MS/MS) in rats. Plasma protein precipitation with methanol was used for sample preparation. For chromatographic separation, a C18 column was used. The mobile phases consisted of 0.1% formic acid and 90% acetonitrile, and gradient elution was used. The following precursor-product ion pairs were selected for reaction monitoring analysis: 319.1 m/z → 157 m/z for ATEC and 361.2 m/z → 185.1 m/z for tributyl citrate (internal standard) in positive ion mode. The LC–MS/MS method was fully validated and successfully applied to a pharmacokinetic study of ATEC in rats. The pharmacokinetic study showed that the volume of distribution and mean residence time of ATEC were higher after oral administration than after intravenous administration, pointing to extensive first-pass metabolism and distribution in tissue. In addition, the plasma concentration profile of the postulated metabolites of ATEC was investigated in plasma, urine, and feces. The resulting data indicated that ATEC was extensively metabolized and excreted mainly as metabolites rather than as the parent form. The developed analytical method and the data on the pharmacokinetics and metabolism of ATEC may be useful for understanding the safety and toxicity of ATEC.

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Assessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalate

Cited by 41 publications

References 34 publications

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

Phthalates Implications in the Cardiovascular System

Pharmacokinetics and Metabolism of Acetyl Triethyl Citrate, a Water-Soluble Plasticizer for Pharmaceutical Polymers in Rats

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