Assessment of endometrial receptivity

Lessey, Bruce A.

doi:10.1016/j.fertnstert.2011.07.1095

Cited by 217 publications

(146 citation statements)

References 186 publications

(187 reference statements)

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“…Under the influence of ovarian hormones, and in the period preceding implantation, the uterine epithelial layer acquires a receptive state (Carson et al, 2000;Lessey, 2011). Implantation is a complicated bidirectional process between the embryo and the endometrium and is regulated by complex signaling pathways.…”

Section: Molecular Changes To the Plasma Membranementioning

confidence: 99%

Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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Successful pregnancy is dependent upon the implantation of a competent embryo into a receptive endometrium. Despite major advancement in our understanding of reproductive medicine over the last few decades, implantation failure still occurs in both normal pregnancies and those created artificially by assisted reproductive technology (ART). Consequently, there is significant interest in elucidating the etiology of implantation failure. The complex multistep process of implantation begins when the developing embryo first makes contact with the plasma membrane of epithelial cells within the uterine environment. However, although this biological interaction marks the beginning of a fundamental developmental process, our knowledge of the intricate physiological and molecular processes involved remains sparse. In this synopsis, we aim to provide an overview of our current understanding of the morphological changes which occur to the plasma membrane of the uterine endothelium, and the molecular mechanisms that control communication between the early embryo and the endometrium during implantation. A multitude of molecular factors have been implicated in this complex process, including endometrial integrins, extracellular matrix molecules, adhesion molecules, growth factors, and ion channels. We also explore the development of in vitro models for embryo implantation to help researchers investigate mechanisms which may underlie implantation failure. Understanding the precise molecular pathways associated with implantation failure could help us to generate new prognostic/diagnostic biomarkers, and may identify novel therapeutic targets.

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Section: Molecular Changes To the Plasma Membranementioning

confidence: 99%

Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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“…При эндометриозе могут повреж-даться все звенья репродукции: оогенез, сперматогенез, эмбриогенез и рецепторная активность эндометрия [50]. Рекомендации по прегравидарной подготовке зависят от распространенности патологического процесса и выра-женности клинических проявлений.…”

Section: наследственные тромбофилииunclassified

Pregravid preparation for women with a history of miscarriage

Пустотина¹,

Ахмедова²

2016

Med. sov.

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“…This step was time limited and was performed through cell surface receptor communication. In the window of implantation [26] -a short period where it is only possible to realize the implantation process, both endometrial and embryonic cells express adhesion molecules and materialize the adhesion. The adhesion molecules are mainly receptors form the integrin family [27].…”

Section: Overview Of Human Embryo Implantation Stages Adhesion Glycomentioning

confidence: 99%