Assessment of endothelial function by flow-mediated dilation of the brachial artery in adolescents with a history of preeclampsia or a normotensive pregnancy

Andrade, Joana Adalgisa Furtado Magalhães; Carvalho, Francisco Herlânio Costa; Mota, Rosa Maria Salani; Andrade, Guilherme Augusto Magalhães; Feitosa, Helvécio Neves; Ibiapina, Flávio Lúcio Pontes; Medeiros, Francisco das Chagas

doi:10.1590/s1519-38292014000100008

Cited by 2 publications

(2 citation statements)

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“…Preeclampsia was also associated with a significant reduction in FMD among the studies that examined women with less severe 23, 34, 54 (Figure S3, Panel A) and more severe 23, 34, 48, 49, 54 (Figure S3, Panel B) forms of preeclampsia.…”

Section: Resultsmentioning

confidence: 95%

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Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia

et al. 2016

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Endothelial dysfunction is believed to play a critical role in preeclampsia, however it is unclear whether this dysfunction precedes the pregnancy or is caused by early pathophysiological events. It is also unclear for how long vascular dysfunction may persist post-partum, and whether it represents a mechanism linking preeclampsia with future cardiovascular disease. Our objective was to determine whether women with preeclampsia have worse vascular function compared to women who did not have preeclampsia by performing systematic review and meta-analysis of studies that examined endothelial dysfunction using flow-mediated dilation (FMD). We included studies published before May 29, 2015 that examined FMD before, during and after preeclampsia. Differences in FMD between study groups were evaluated by standardized mean differences. Out of 610 abstracts identified through PubMED, EMBASE and Web of Science, 37 studies were eligible for the meta-analysis. When compared to women who did not have preeclampsia, women who had preeclampsia had lower FMD prior to the development of preeclampsia (~20–29 weeks gestation), at the time of preeclampsia, and for three years post-partum, with the estimated magnitude of the effect ranging between 0.5 and 3 standard deviations. Similar effects were observed when the analysis was limited to studies that excluded women with chronic hypertension, smokers, or both. Vascular dysfunction predates preeclampsia and may contribute to its pathogenesis. Future studies should address whether vascular changes that persist after preeclamptic pregnancies may represent a mechanistic link with the increased risk for future cardiovascular disease.

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Section: Resultsmentioning

confidence: 95%

“…Six prospective cohort studies, 20, 23, 32, 34, 35, 38 eight cross-sectional studies, 47–54 and one randomized controlled trial of exercise training 55 were eligible for the meta-analysis (Tables S3, S6). These studies included 429 women who had a history of preeclampsia and 470 women who did not have a history of preeclampsia.…”

Section: Resultsmentioning

confidence: 99%