Assessment of epinephrine sublingual stability and permeability pathways to enhance its permeability for the treatment of anaphylaxis

Rawas‐Qalaji, Mutasem; Bafail, Rawan; Cagliani, Roberta; Haider, Mohamed; Hussain, Zahid

doi:10.1016/j.ejps.2021.106025

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…In 2006, the sublingual administration of epinephrine 40 mg by tablet formulation resulted in epinephrine plasma concentrations similar to those obtained after epinephrine 0.3 mg intramuscular injection in the thigh 57 . In 2021, a novel fast‐disintegrating sublingual tablet showed the feasibility of using the sublingual route of delivery for epinephrine 58 …”

Section: Management Optionsmentioning

confidence: 90%

“…57 In 2021, a novel fast-disintegrating sublingual tablet showed the feasibility of using the sublingual route of delivery for epinephrine. 58 The term 'gastrointestinal anaphylaxis' describe rapid onset of severe abdominal signs and symptoms as the sole allergic reaction or as part of systemic anaphylaxis. 59 There is currently no treatment that specifically addresses abdominal pain or uterine cramping during food-induced anaphylaxis.…”

Section: Avoidance and Rescue Medicationmentioning

confidence: 99%

“… 57 In 2021, a novel fast‐disintegrating sublingual tablet showed the feasibility of using the sublingual route of delivery for epinephrine. 58 …”

Section: Management Optionsmentioning

confidence: 99%

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Management of IgE‐mediated food allergy in the 21st century

Cafarotti

Giovannini

Bégin

et al. 2022

Clin Experimental Allergy

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Food allergy is defined as an immune-mediated adverse reaction to food 1 consisting in a loss of tolerance to harmless environmental substances.An increase in food allergy epidemiological burden has been reported in the last few decades. 2 In parallel, hospital admissions for food-induced anaphylaxis appear to be increased. 3,4 A systematic review estimated the pooled lifetime and point prevalence of self-reported food allergy in Europe as 17.3% (95% CI: 17.0-17.6) and 5.9% (95% CI: 5.7-6.1), respectively. However, positive oral food challenge (OFC) rate was estimated as 0.9% (95%

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Section: Management Optionsmentioning

confidence: 90%

Section: Avoidance and Rescue Medicationmentioning

confidence: 99%

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Management of IgE‐mediated food allergy in the 21st century

Cafarotti

Giovannini

Bégin

et al. 2022

Clin Experimental Allergy

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“…Saliva samples were collected and filtered from ten people aged between 18 and 40. The formulations from the finest batch were placed in separate Petri dishes containing 5 mL of human saliva, and they were stored in a 37 ± 0.2 °C oven for six hours [ 43 , 44 ]. At regular intervals, the appearance of the buccoadhesive formulations, such as the colour and the shape, and the Nifedipine concentration were both evaluated in order to determine their stability.…”

Section: Methodsmentioning

confidence: 99%

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Alagusundaram,

Jain,

Begum

et al. 2023

Gels

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A promising controlled drug delivery system has been developed based on polymeric buccoadhesive bilayered formulation that uses a drug-free backing layer and a polymeric hydrophilic gel buccoadhesive core layer containing nifedipine. The DSC thermogravimetric analysis confirms the drug’s entrapment in the gel layer and reveals no evidence of a potential interaction. Various ratios of bioadhesive polymers, including HPMC K100, PVP K30, SCMC, and CP 934, were combined with EC as an impermeable backing layer to ensure unidirectional drug release towards the buccal mucosa. The polymeric compositions of hydrophilic gel-natured HPMC, SCMC, and CP formed a matrix layer by surrounding the core nifedipine during compression. Preformulation studies were performed for all of the ingredients in order to evaluate their physical and flow characteristics. Ex vivo buccoadhesive strength, surface pH, swelling index, in vitro and in vivo drug release, and ex vivo permeation investigations were performed to evaluate the produced gel-based system. Rapid temperature variations had no appreciable impact on the substance’s physical properties, pharmacological content, or buccoadhesive strength during stability testing using actual human saliva. It was clear from a histological examination of the ex vivo mucosa that the developed system did not cause any irritation or inflammation at the site of administration. The formulation NT5 was the best one, with a correlation coefficient of 0.9966. The in vitro and in vivo drug release profiles were well correlated, and they mimic the in vitro drug release pattern via the biological membrane. Thus, the developed gel-based formulation was found to be novel, stable, and useful for the targeted delivery of nifedipine.

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