Assessment of erectile dysfunction and associated psychological distress in Chinese men with type 2 diabetes mellitus

Chen, S; Peng, Dangwei; Xu, Xin; Gao, Jingjing; Dai, Fang; Zuo, Chengchao; Zhang, Q

doi:10.1038/ijir.2017.25

Cited by 19 publications

(14 citation statements)

References 35 publications

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“…The Massachusetts Male Ageing Study (MMAS) demonstrated a direct correlation between indexes of anger, depression and ED within middle‐aged to senior groups (40–70 years) (Feldman et al, 1994). Anxiety and depression evaluated by the SCL‐90‐R subscales were correlated with IIEF‐5 scores in type 2 diabetes mellitus patients (Chen et al, 2017). Furthermore, among patients with ED alone or ED combined with premature ejaculation, patients diagnosed with worse ED (measured by the IIEF) had worse psychological conditions (Mourikis et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Is milder psychological stress responsible for more severe erectile dysfunction?

Liao

Tang

et al. 2020

Andrologia

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China is a sexually conservative country compared with Western countries. To evaluate the psychological characteristics of Chinese erectile dysfunction (ED) patients, we conducted a cross‐sectional study of 153 ED outpatients. Patients were interviewed with the Structured Interview on Erectile Dysfunction (SIEDY) for pathogenic quantification. ED was measured by International Index of Erectile Function (IIEF). Depression and anxiety were evaluated with 9‐item Patient Health Questionnaire (PHQ‐9) and 7‐item Generalised Anxiety Disorder Scale (GAD‐7) respectively. Most patients (74.5%) were <40 years old. IIEF‐5 were significantly correlated with SIEDY scale 3 (r = .16, p = .040) and GAD‐7 (p = .15, p = .033). The SIEDY scale 1 increased with age, but the IIEF‐5, SIEDY scale 3, PHQ‐9 and GAD‐7 decreased with age. A negative correlation was observed between ED and psychological stress, which conflicts with many Western‐country studies. Younger patients were characterised by milder ED but more psychological stress, while older patients were characterised by worse ED but less psychological stress. Which may be responsible for the conflicting result. Meanwhile, the much younger age distribution among Chinese ED outpatients may indicate that quite a few older ED patients (≥40 years) in China do not seek outpatient service which should merit more attention.

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Section: Introductionmentioning

confidence: 99%

Is milder psychological stress responsible for more severe erectile dysfunction?

Liao

Tang

et al. 2020

Andrologia

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“…There are many theories on hypogonadism and erectile dysfunction in diabetes, with causes ranging from vasculopathy to neuropathy and endocrinopathy [ 4 ]. Some studies have even claimed psychogenic causes to be one of the most challenging treatment dilemmas for patients with diabetic erectile dysfunction [ 5 ]. However, it is unknown at present whether diabetes brings about any changes in the personal effects that result in erectile dysfunction or there are any other underlying factors that cause changes in the psychology of the patients [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The study was conducted following the principles of good clinical practice, as laid down in the Declaration of Helsinki, after approval of its synopsis by the ethical review board of Allama Iqbal Medical College, Lahore. A sample size of 160 cases was calculated using a 95% confidence level and a 5% margin of error and taking the expected frequency of hypogonadism to be 11.8% in patients with Type-II diabetic patients [ 5 ]. Patients aged between 20 and 60 years diagnosed with type-II diabetes mellitus in the past 24 months were recruited in the study using non-probability, consecutive sampling.…”

Section: Methodsmentioning

confidence: 99%

“…The reported frequency of hypogonadism and erectile dysfunction varies from 11.8% to 97.2% in different populations [ 2 - 4 ]. A possible explanation for this variation among studies can be the population differences, patient’s compliance and diabetic control, and the overall sexual health of the patients [ 5 - 7 ]. The topic has little attention in the recent medical literature from our country.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Hypogonadism and Erectile Dysfunction in Type-II Diabetic Patients

Mushtaq

Khan

Abid

et al. 2018

Cureus

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Introduction: The persistent state of hyperglycemia in diabetes mellitus predisposes diabetic patients to suffer from neuropathy, vasculopathy, and endocrinological changes. Hypogonadism and erectile dysfunction are commonly observed in diabetic patients secondary to androgen deficiency. In the developing world, patients usually under-report their sexual dysfunction. We conducted this study to determine the frequency of hypogonadism and erectile dysfunction and the associated risk factors in type-II diabetic male patients presenting in the outpatient department of a tertiary care hospital in Pakistan.Methods: This was an observational, cross-sectional hospital-based study conducted at Jinnah Allama Iqbal Institute of Diabetes and Endocrinology (JAIDE), Allama Iqbal Medical College/Jinnah Hospital, Lahore, Pakistan from April 2017 to October 2017. One hundred and sixty type-II diabetic patients meeting the inclusion criteria were enrolled in the study after informed consent. All patients were given the International Index of Erectile Function (IIEF) questionnaire to determine the severity of erectile dysfunction. Patients were tested for serum total testosterone levels and hypogonadism labeled if the serum testosterone level came out to be less than 8 nmol/L with or without symptoms of hypogonadism or with a testosterone level of 8-12 nmol/L and symptoms of hypogonadism.Results: The mean age of the patients was 51.2 ± 11.5 years (range: 31 – 60 years). The mean duration of type-II diabetes mellitus was 8.3 ± 5.1 years. The frequency of erectile dysfunction was found to be 62.5%. Mild erectile dysfunction was seen in 19 patients (11.9%), mild to moderate in 15 patients (9.4%), moderate in 42 patients (26.2%), and severe in 24 patients (15.0%) with an IIEF score of 17-21, 12-16, 8-11, and 1-7, respectively. More severe erectile dysfunction was seen in patients with a prolonged history of diabetes (p-value <0.0001). The mean testosterone level was 18.1 + 8.4 (range: 0.31-38.1) nmol/L. Based on our criteria, hypogonadism was seen in 61 patients (38.1%) with 29 (18.1%) and 32 (20.0%) suffering from severe and mild forms of hypogonadism, respectively. Forty percent of the patients with erectile dysfunction suffered from some form of hypogonadism with subnormal testosterone levels. The difference in the testosterone level of patients with and without erectile dysfunction was statistically significant (p-value: 0.0001).Conclusion: Patients suffering from type-II diabetes mellitus had a significantly greater frequency of erectile dysfunction and hypogonadism. Diabetic patients should be counseled and treated for these issues to improve their quality of life, especially in under-developed countries where sexual health problems are seldom reported.

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“…Neurogenic ED was diagnosed by identifying a history of spinal cord lesions or pelvic surgery [9]. To evalu-ate the patients' psychological issues, we used a Chinese version of the Symptom Checklist-90 [10][11][12], a multidimensional symptom self-reporting inventory composed of 90 items, each rated on a 5-point scale of distress from 0 (not at all) to 4 (extremely) [13]. The global severity index (GSI) provided a summary score for the number and intensity of psychological distresses, and was determined by adding raw scores from all dimensions divided by the total number of items (90) [14].…”

Section: Subjectsmentioning

confidence: 99%

Time-effect of penile color duplex Doppler ultrasound for diagnosing vascular erectile dysfunction

Wang

Liu

et al. 2020

Med Ultrason

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Introduction: This study aimed to explore the time-effect of color duplex Doppler ultrasound (CDDU) in the diagnosis of vascular erectile dysfunction (ED).Material and methods: Using a self-control study, we included patients who underwent penile CDDU and cavernosography in our hospital. We compared the arterial peak systolic velocity (PSV) of CDDU among different intervals for the diagnosis of arterial ED. We included 357 patients who were under consideration for vascular ED.Results: We found significant differences in all the pairwise comparison of PSV in the 1st (0–5 min), 2nd (6–10 min), 3rd (11–15 min), and 4th (16–20 min) 4 intervals after the injection of prostaglandin E1 (p<0.001), except the 11–15 min vs. the 16–20 min interval (p=0.387). Using cavernosography, 294 patients were diagnosed with venous ED. Compared with other intervals, the diagnosis of CDDU 11–15 min after the intracavernous injection of 20 ug prostaglandin E1 (PGE1) had the best consistency with cavernosography (Kappa=0.761; p<0.001). Compared with other intervals, CDDU at 11–15 min had the highest specificity (93.65%), the highest Youden index (0.85), positive likelihood ratio of 14.46, positive predictive value of 98.54%, negative predictive value of 71.08% and a coincidence rate of 92.16%.Conclusions: Our findings support the increased utilization of CDDU for the diagnosis of both arterial and venous ED. The diagnosis at 11–15 min after intracavernous injection of PGE1 is accurate and stable, which would help to simplify the process and shorten the time of CDDU.

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Assessment of erectile dysfunction and associated psychological distress in Chinese men with type 2 diabetes mellitus

Cited by 19 publications

References 35 publications

Is milder psychological stress responsible for more severe erectile dysfunction?

Is milder psychological stress responsible for more severe erectile dysfunction?

Frequency of Hypogonadism and Erectile Dysfunction in Type-II Diabetic Patients

Time-effect of penile color duplex Doppler ultrasound for diagnosing vascular erectile dysfunction

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