Assessment of extracellular matrix proteins (laminin and fibronectin) in adenoid cystic carcinoma of salivary gland using morphometric method

Wegner, Anna; Waśniewska, Elżbieta; Golusiński, Paweł

doi:10.1016/s1507-1367(10)60074-0

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Similar to the results regarding vimentin expression, fibronectin seems to act as a key player in the process of SACC invasiveness. In solid subtypes, fibronectin expression was observed to diminish in the outer region of invasive tumor clusters, while strong expression was detected in neoplastic cells that surround and infiltrate the nerve fibers, suggesting its potential dual role in promoting PNI, while potentially inhibiting invasion at the invasive tumor front [73,[97][98][99]. In contrast, other studies have found lower fibronectin expression in the solid SACC variant compared to the tubular and cribriform subtypes [100,101].…”

Section: The Complex Role Of Fibronectin In Sacc: Promoting Pni Inhib...mentioning

confidence: 99%

Unraveling the Role of Epithelial–Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Hoch

Stögbauer

Wollenberg

2023

Cancers

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Salivary adenoid cystic carcinoma (SACC) is considered a challenging malignancy; it is characterized by a slow-growing nature, yet a high risk of recurrence and distant metastasis, presenting significant hurdles in its treatment and management. At present, there are no approved targeted agents available for the management of SACC and systemic chemotherapy protocols that have demonstrated efficacy remain to be elucidated. Epithelial–mesenchymal transition (EMT) is a complex process that is closely associated with tumor progression and metastasis, enabling epithelial cells to acquire mesenchymal properties, including increased mobility and invasiveness. Several molecular signaling pathways have been implicated in the regulation of EMT in SACC, and understanding these mechanisms is crucial to identifying new therapeutic targets and developing more effective treatment approaches. This manuscript aims to provide a comprehensive overview of the latest research on the role of EMT in SACC, including the molecular pathways and biomarkers involved in EMT regulation. By highlighting the most recent findings, this review offers insights into potential new therapeutic strategies that could improve the management of SACC patients, especially those with recurrent or metastatic disease.

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Section: The Complex Role Of Fibronectin In Sacc: Promoting Pni Inhib...mentioning

confidence: 99%

Unraveling the Role of Epithelial–Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Hoch

Stögbauer

Wollenberg

2023

Cancers

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“…Most of the authors revealed a positive fibronectin reaction in all investigated specimens of salivary ACC, most prevalent with filamentous pattern but also as irregular forms both in matrix and inside pseudocyst [38][39][40]. Wegner et al (2007) found a lower fibronectin expression in the tubular variant of salivary ACC compared with two other types solid and cribriform [40]. Also, the authors speculated that this expression might have prognostic role.…”

Section: Figure 7 -(A) Statistical Analysis Proving a Strong Correlation Between E-cadherin And Vimentin Ihc Scores (R=0999 P=0027) (B) Amentioning

confidence: 99%

Immunophenotypical alterations with impact on the epithelial–mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas

Belulescu

Mărgăritescu

Dumitrescu³

et al. 2020

Rom J Morphol Embryol

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Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary glands neoplasms with an indolent clinical course, slow-growing but locally aggressive and quite often with delayed recurrence and distant metastasis. In order to elucidate this tumoral behavior, we conducted an immunohistochemical study investigating the alterations of epithelial phenotype with anti-cytokeratin (CK) AE1/AE3 and anti-E-cadherin antibodies, and the acquisition of mesenchymal phenotype with vimentin, fibronectin, N-cadherin and P-cadherin in salivary ACCs. Thus, we recorded a reduction of CK AE1/AE3, E-cadherin, P-cadherin and fibronectin reactivity in the solid variant and especially in the cells from the periphery of invasive neoplastic proliferations, regardless histological type. These phenotypical alterations suggest the involvement of the epithelial-mesenchymal transition (EMT) process in the progression of salivary ACCs.

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Assessment of extracellular matrix proteins (laminin and fibronectin) in adenoid cystic carcinoma of salivary gland using morphometric method

Cited by 2 publications

References 9 publications

Unraveling the Role of Epithelial–Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Unraveling the Role of Epithelial–Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Immunophenotypical alterations with impact on the epithelial–mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas

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