Assessment of factors contributing to changes in the incidence of antimicrobial drug resistance in Salmonella enterica serotypes Enteritidis and Typhimurium from humans in England and Wales in 2000, 2002 and 2004

Threlfall, E. J.; Day, Martin J.; Pinna, Elizabeth de; Charlett, André; Goodyear, K.L.

doi:10.1016/j.ijantimicag.2006.07.009

Cited by 40 publications

(22 citation statements)

References 14 publications

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“…The results obtained for nalidixic acid (25%), and ciprofloxacin (3.75%) are of concern, because recent studies have detected increases in isolation of Salmonella spp strains resistant to quinolones in Germany (Malorny, Schoroeter, & Helmuth, 1999), England and Wales (Threlfall, Day, Pinna, Charlett, & Goodyear, 2006) and Spain (Marimón, Gomáriz, Zigorraga, Cilla, & Pérez-Trallero, 2004). Recently, the CLSI added a guideline recommending clinical laboratories to routinely test for nalidixic acid resistance in extraintestinal Salmonella isolates to alert physicians of the emerging resistance (Clinical & Laboratory Standards Institute (CLSI/NCCLS), 2004).…”

Section: Resultsmentioning

confidence: 99%

Characterization of Salmonella Enteritidis isolated from human samples

Oliveira

Pasqualotto

Silva

et al. 2012

Food Research International

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Section: Resultsmentioning

confidence: 99%

Characterization of Salmonella Enteritidis isolated from human samples

Oliveira

Pasqualotto

Silva

et al. 2012

Food Research International

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“…None of the isolates were resistant to ciprofloxacin, another first-line antimicrobial for salmonellosis (Guerrant et al, 2001), although many were resistant to nalidixic acid (8/14), which has been found to be an indicator of low level resistance to fluoroquinolones (I. Rodriguez-Avial et al, 2005;Threlfall et al, 2006) and may be a first step towards the development of resistance to ciprofloxacin (Van Looveren et al, 2001). Other common antimicrobial resistances exhibited among the resistant isolates were to sulfisoxazole (10/14), tetracycline (9/ 14), chloramphenicol (6/14), streptomycin (5/14), kanamycin (4/14) and ampicillin (3/14).…”

Section: Antimicrobial Resistance Of Salmonella In Spicesmentioning

confidence: 99%

Prevalence, serotype diversity, and antimicrobial resistance of Salmonella in imported shipments of spice offered for entry to the United States, FY2007–FY2009

Doren¹,

Kleinmeier²,

Hammack³

et al. 2013

Food Microbiology

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a b s t r a c tIn response to increased concerns about spice safety, the U.S. FDA initiated research to characterize the prevalence of Salmonella in imported spices. Shipments of imported spices offered for entry to the United Sates were sampled during the fiscal years 2007e2009. The mean shipment prevalence for Salmonella was 0.066 (95% CI 0.057e0.076). A wide diversity of Salmonella serotypes was isolated from spices; no single serotype constituted more than 7% of the isolates. A small percentage of spice shipments were contaminated with antimicrobial-resistant Salmonella strains (8.3%). Trends in shipment prevalence for Salmonella associated with spice properties, extent of processing, and export country, were examined. A larger proportion of shipments of spices derived from fruit/seeds or leaves of plants were contaminated than those derived from the bark/flower of spice plants. Salmonella prevalence was larger for shipments of ground/cracked capsicum and coriander than for shipments of their whole spice counterparts. No difference in prevalence was observed between shipments of spice blends and non-blended spices. Some shipments reported to have been subjected to a pathogen reduction treatment prior to being offered for U.S. entry were found contaminated. Statistical differences in Salmonella shipment prevalence were also identified on the basis of export country.Published by Elsevier Ltd.

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“…This finding illustrates that even this seemingly straightforward issue may not be as clear-cut as it originally appeared. Threlfall et al (2006) examined changes in the occurrence of antimicrobial resistance in other zoonotic pathogens, Salmonella enterica serotypes Enteritidis and Typhimurium obtained from human infections in England and Wales (2000, 2002 and 2004). These investigators showed that the incidence of strains of S. enteritidis with resistance to nalidixic acid, coupled with decreased susceptibility to ciprofloxacin, had more than doubled between 2000 and 2004.…”

Section: Impact Of Antibiotic Use On Resistancementioning

confidence: 99%

“…In their final analysis, Threlfall et al (2006) concluded that changes in the incidence of resistance in predominant Salmonella spp. in human patients in England and Wales are multifactorial.…”

Section: Impact Of Antibiotic Use On Resistancementioning

confidence: 99%

Antimicrobial Drug Resistance

Martinez

Silley²

2010

Comparative and Veterinary Pharmacology

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This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a matrix of complex variables that includes the mechanism of drug action, the pharmacokinetics (PK) of the antimicrobial agent in the targeted patient population, the pharmacodynamics (PD) of the bacterial response to the antimicrobial agent, the PK/PD relationship that will influence dose selection, and the integrity of the host immune system. Finally, the differences between bacterial tolerance and bacterial resistance are considered, and the potential for non-traditional anti-infective therapies is discussed.

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Assessment of factors contributing to changes in the incidence of antimicrobial drug resistance in Salmonella enterica serotypes Enteritidis and Typhimurium from humans in England and Wales in 2000, 2002 and 2004

Cited by 40 publications

References 14 publications

Characterization of Salmonella Enteritidis isolated from human samples

Characterization of Salmonella Enteritidis isolated from human samples

Prevalence, serotype diversity, and antimicrobial resistance of Salmonella in imported shipments of spice offered for entry to the United States, FY2007–FY2009

Antimicrobial Drug Resistance

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