“…Secondary outcome measures were changes in the appendicular skeletal mass index (ASMI), skeletal muscle mass index (SMI), body composition, handgrip strength, biomarkers [lactate, creatine kinase (CK), insulin growth factor (IGF)-1, growth hormone (GH), and high-sensitivity C-reactive protein (hs-CRP) concentrations], and Euro-QoL-5D (EQ-5D) score, which is representative of the quality of life, 19 within the 12-week treatment period. Lactate, CK, IGF-1, and GH concentrations were measured to assess exercise-induced fatigue 20 and hs-CRP concentrations were measured to determine the inflammatory status (ESI Table 1 †). 21 The study was conducted at the Department of Basic Science Research Institute and the Department of Physical Education of Kyungnam University, Changwon, South Korea.…”