Assessment of fatty acid metabolism in taxan-induced myocardial damage with iodine-123 BMIPP SPECT: Comparative study with myocardial perfusion, left ventricular function, and histopathological findings

Saito, Kimimasa; Takeda, Kan; Imanaka‐Yoshida, Kyoko; Imai, Hiroshi; Sekine, Takao; Kamikura, Yuko

doi:10.1007/bf03006439

Cited by 27 publications

(20 citation statements)

References 16 publications

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“…Novel SPECT techniques for early detection of cardiotoxicity are shown in Table 6. 46 These novel techniques include static volume indices and functional LV indices by gated SPECT ERNA and MPI, 27,28 sympathetic neuronal imaging with a wide variety of SPECT and PET tracers, [47][48][49][50][51][52][53][54][55] In-111 antimyosin which is a specific marker of myocyte injury and necrosis, 54,56,57 Tc-99m annexin V which visualized apoptosis and programmed cell death, [58][59][60] fatty acid scintigraphy which visualizes fatty acid retention in the lipid pool of the cytosol which can be impaired by cardiotoxic agents, 61 and direct imaging of In-111 trastuzumab to study trastuzumab targeting of the myocardium have been considered. 62 Each of these techniques would require a prospective clinical trial to assess its incremental value in avoiding clinical CHF.…”

Section: Novel Scintigraphic Methodsmentioning

confidence: 99%

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Traditional and novel methods to assess and prevent chemotherapy-related cardiac dysfunction noninvasively

Schwartz

Jain

Storozynsky

2013

Journal of Nuclear Cardiology

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The field of cardio-oncology is challenged to address an ever greater spectrum of cardiotoxicity associated with combination chemotherapy, greater dose intensity, extremes of age, and enhanced patient survival which exposes more protracted risk of developing congestive heart failure (CHF). Recent reports of chemotherapy-induced hypertension as a common adverse effect of angiogenesis inhibitors and immunosuppressants clarify the need for routine blood pressure (BP) monitoring and guideline-based management of hypertension as an integral strategy to preserve LV function. Serial monitoring of radionuclide left ventricular ejection fraction (LVEF) in adults and echocardiography in children continues to provide outcome based, cost-effective prevention of CHF in high risk patients receiving chemotherapy. To optimize treatment and monitoring strategies to eliminate late-onset LV dysfunction and CHF, traditional and novel candidate methods for assessment of chemotherapy-induced LV dysfunction are reviewed. These include serial assessment of LV volume indices by gated SPECT ERNA and gated SPECT MPI, 3D echocardiography and contrast 2D echocardiography; longitudinal strain imaging, diastolic functional parameters, 123 I-MIBG, 111 In-Antimyosin antibody imaging, and 99m Tc-Annexin V apoptosis imaging, biomarkers including troponins and BNP; genetic markers, and both functional and tissue characterization techniques with T1 weighted and T2 weighted images with cardiac magnetic resonance imaging (CMR). In our quest to optimize strategies for long-term cancer survival and prevention of CHF for patients receiving chemotherapy, rigorous modality and guideline-specific clinical outcome trials are required. A new multi-modality monitoring approach is proposed, which integrates evidencebased strengths of CMR, echocardiography, ERNA, biomarkers, and BP management for surveillance and validation of cardiotoxicity and prevention of clinical heart failure in patients receiving a broad spectrum of cancer therapies.

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Section: Novel Scintigraphic Methodsmentioning

confidence: 99%

“…61 Taxanes in combination with carboplatin are reported to exert a more profound depression on myocardial FFA metabolism and myocardial contractile dysfunction than doxorubicin alone. The incremental value of reduced 123 I BMIPP or 123 I IPPA metabolism on prediction of chemotherapyinduced CHF remains undefined.…”

Section: Fatty Acidsmentioning

confidence: 99%

Traditional and novel methods to assess and prevent chemotherapy-related cardiac dysfunction noninvasively

Schwartz

Jain

Storozynsky

2013

Journal of Nuclear Cardiology

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“…They demonstrated that combination therapy with taxane and carboplatin did not affect myocardial perfusion but could impair fatty acid metabolism (109). A decrease of myocardial 123 I-BMIPP uptake took place in 56% of patients after treatment.…”

Section: Fatty Acid Usementioning

confidence: 99%

“…As a result, uptake of free fatty acids by the mitochondria may be reduced. This process can be reflected by 123 I-15-(piodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) scintigraphy or 123 I-paraphenyl pentadecanoic acid scintigraphy (106,109).…”

Section: Fatty Acid Usementioning

confidence: 99%

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

et al. 2011

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New antitumor agents have resulted in significant survival benefits for cancer patients. However, several agents may have serious cardiovascular side effects. Left ventricular ejection fraction measurement by 99m Tc multigated radionuclide angiography is regarded as the gold standard to measure cardiotoxicity in adult patients. It identifies left ventricular dysfunction with high reproducibility and low interobserver variability. A decrease in left ventricular ejection fraction, however, is a relatively late manifestation of myocardial damage. Nuclear cardiologic techniques that visualize pathophysiologic processes at the tissue level could detect myocardial injury at an earlier stage. These techniques may give the opportunity for timely intervention to prevent further damage and could provide insights into the mechanisms and pathophysiology of cardiotoxicity caused by anticancer agents. This review provides an overview of past, current, and promising newly developed radiopharmaceuticals and describes the role and recent advances of scintigraphic techniques to measure cardiotoxicity. Both first-order functional imaging techniques (visualizing mechanical [pump] function), such as 99m Tc multigated radionuclide angiography and 99m Tc gated blood-pool SPECT, and third-order functional imaging techniques (visualizing pathophysiologic and neurophysiologic processes at the tissue level) are discussed. Third-order functional imaging techniques comprise 123 I-metaiodobenzylguanidine scintigraphy, which images the efferent sympathetic nervous innervations; sympathetic neuronal PET, with its wide range of tracers; 111 In-antimyosin, which is a specific marker for myocardial cell injury and necrosis; 99m Tc-annexin V scintigraphy, which visualizes apoptosis and cell death; fatty-acid-use scintigraphy, which visualizes the storage of free fatty acids in the lipid pool of the cytosol (which can be impaired by cardiotoxic agents); and 111 In-trastuzumab imaging, to study trastuzumab targeting to the myocardium. To define the prognostic importance and clinical value of each of these functional imaging techniques, prospective clinical trials are warranted.

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“…A study by Saito, et al, demonstrated early decreased uptake of 123 I-BMIPP in patients with preserved LV function after treatment with an anthracycline; similar decreases in 123 I-BMIPP uptake were observed in patients experiencing a decline in LVEF after receipt of a taxane and carboplatin (104,105). Recently, Carboni, et al, evaluated mitochondrial metabolism with 99m Tc-sestamibi (MIBI) in patients receiving multi-agent chemotherapy.…”

Section: Myocardial Metabolism Imagingmentioning

confidence: 80%

Noninvasive Imaging of Cardiovascular Injury Related to the Treatment of Cancer

Kongbundansuk

Hundley

2014

JACC: Cardiovascular Imaging

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The introduction of multiple treatments for cancer, including chemotherapeutic agents and radiation therapy, has significantly reduced cancer-related morbidity and mortality. However, these therapies can promote a variety of toxicities, among the most severe being the ones involving the cardiovascular system. Currently, for many surviving cancer patients, cardiovascular (CV) events represent the primary cause of morbidity and mortality. Recent data suggests that CV injury occurs early during cancer treatment, creating a substrate for subsequent cardiovascular events. Researchers have investigated the utility of noninvasive imaging strategies to detect the presence of CV injury during and after completion of cancer treatment because it starts early during cancer therapy, often preceding the development of chemotherapy or cancer therapeutics related cardiac dysfunction. In this state of the art article, we review the utility of current clinical and investigative CV noninvasive modalities for the identification and characterization of cancer treatment-related CV toxicity.

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Assessment of fatty acid metabolism in taxan-induced myocardial damage with iodine-123 BMIPP SPECT: Comparative study with myocardial perfusion, left ventricular function, and histopathological findings

Abstract: Taxan impairs myocardial fatty acid metabolism. 123I-BMIPP myocardial SPECT is useful for evaluating the cardiotoxicity induced by taxan.

Cited by 27 publications

References 16 publications

Traditional and novel methods to assess and prevent chemotherapy-related cardiac dysfunction noninvasively

Traditional and novel methods to assess and prevent chemotherapy-related cardiac dysfunction noninvasively

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

Noninvasive Imaging of Cardiovascular Injury Related to the Treatment of Cancer

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