Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study

Ayhan, Şule Göncü; Atalay, Altay; Sınacı, Selcan; Tokalıoğlu, Eda Özden; Şahın, Dilek; Tekın, Özlem Moraloğlu

doi:10.1515/jpm-2020-0512

Cited by 18 publications

(29 citation statements)

References 35 publications

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“…The possible effect of COVID-19 on fetal Doppler parameters was also investigated in current studies [68,69]. No difference was present between healthy pregnant women and those with mild/moderate COVID-19 in terms of fetal Doppler parameters [69]. However, the pulsatility and resistance indices of umbilical and uterine arteries showed a significant increase in pregnant women recovered from COVID-19 compared to the controls [68].…”

Section: Obstetric and Neonatal Complicationsmentioning

confidence: 79%

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Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Şahın¹,

Webster²,

Tekın³

2021

Turk J Med Sci

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Coronavirus disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Although more than 90% of pregnant women with COVID-19 recover without serious morbidity, rapid deterioration of disease and higher rates of obstetric complications may be observed. The risk of vertical transmission has not been clearly revealed, yet. Decreasing the number of prenatal visits, shortening the time allocated for the examinations, active use of telemedicine services, limiting the number of persons in health-care settings, combining prenatal tests in the same visit, restricting visitors during the visits, providing a safe environment in health-care facilities, strict hygene control and providing personal protective equipment during the visits are the main strategies to control the spread of disease according to current guidelines. Although new medication alternatives are being proposed every day for the treatment of COVID-19, our knowledge about the use of most of these drugs in pregnancy is limited. Preliminary results are promising for the administration of SARS-CoV-2 vaccines in the pregnant population. Timing of delivery should be decided based on maternal health condition, accompanying obstetric complications and gestational age. Cesarean delivery should be performed for obstetric indications. Breast feeding should be encouraged as long as necessary precautions for viral transmission are

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Section: Obstetric and Neonatal Complicationsmentioning

confidence: 79%

Section: Obstetric and Neonatal Complicationsmentioning

confidence: 80%

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Şahın¹,

Webster²,

Tekın³

2021

Turk J Med Sci

Self Cite

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“…Fetal Doppler assessment in COVID‐19 patients is reported to be similar to those in healthy patients, although disagreement exists 23–25 . Furthermore, in COVID‐19 pregnant patients, impaired placental function or Doppler abnormalities seem not to be linked with fetal growth restrictions in second half of pregnancy 9 .…”

Section: Discussionmentioning

confidence: 97%

Acute SARS‐CoV‐2 alpha variant infection leading to placental insufficiency and fetal distress

Dumont

Balduyck

Vanwalleghem

et al. 2021

Journal of Medical Virology

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The effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Alpha variant (also known as B.1.1.7 lineage, 20I/501Y.V1, the UK variant or VOC 202012/01) infection on pregnancy is currently unknown.We present a case of a 37-year-old woman admitted to our tertiary hospital at a gestational age of 29 weeks and 1 day because of oligohydramnios with reduced fetal movements for 10 days. About 20 days before admission, she tested positive for SARS-CoV-2 Alpha variant. The following day, due to abnormal cardiotocography, increased brain sparing, and absent end-diastolic flow in the umbilical artery, an urgent cesarean section was performed. The neonate had an uneventful admission to the neonatal intensive care unit. All neonatal samples proved negative for SARS-CoV-2.Pathological examination of the placenta revealed intervillous fibrin deposition, ischemic necrosis of villi and histiocytic intervillositis, corresponding with the SARS-CoV-2 placentitis triad. The placental tissue demonstrated a high viral load, possibly explaining the acute onset of placental insufficiently and subsequent fetal distress. This case demonstrates the importance of seeking medical care when experiencing reduced fetal movement in SARS-CoV-2 infected patients since acute infection can induce significant placental and subsequent fetal pathology.

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“…Regretfully, the fetal effects of SARS-CoV-2 infection are still uncertain. In our previous study, we found that COVID-19 infection has no negative effect on Doppler parameters in pregnant women (15). However, due to hyper inflammation, hypoxia, and stress-related conditions; fetal thymus size might be reduced in COVID-19 positive pregnancies.…”

Section: Introductionmentioning

confidence: 85%

Fetal Thymus Size in Pregnant Women with COVID-19 Infection

Ayhan¹,

Oluklu

Sınacı

et al. 2021

Gynecol Obstet Reprod Med

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OBJECTIVE: To determine the effect of SARS-CoV-2 infection on fetal thymus size by ultrasound. STUDY DESIGN: In this prospective study sonographic fetal thymus size was measured in pregnant women attending our hospital with confirmed SARS-CoV-2 infection by RT-PCR test and age-matched control group. The anteroposterior thymic and the intrathoracic mediastinal diameter was determined in the three-vessel view and their quotient, the thymic-thoracic ratio, was calculated. Results were compared between these two groups. RESULTS: Thirty-six SARS-CoV-2-infected and 47 control group pregnant women were included in this study. Two groups were similar in terms of demographic features and no difference was found for fetal thymus size. CONCLUSION: COVID-19 seems to have no adverse effect on fetal thymus size in mild and moderate patients during the acute phase of the infection.

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Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study

Cited by 18 publications

References 35 publications

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Acute SARS‐CoV‐2 alpha variant infection leading to placental insufficiency and fetal distress

Fetal Thymus Size in Pregnant Women with COVID-19 Infection

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