Assessment of Flow Mediated Dilatation of Brachial Artery by Angiodefender Device as Compared to Brachial Artery Ultrasound Imaging.

Sharma, Mukesh Kumar; Chandan, Chandra Bhanu; Shukla, Abhishek; Ameta, Deepak; Kurmi, Pradeep

doi:10.32553/ijmbs.v3i6.312

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…In brief, a proprietary software algorithm was used to analyze the high resolution continuous electrocardiogram-gated B-mode ultrasound imaging during reactive hyperemia in brachial artery. The equivalence of FMD determined by the AngioDefender™ and the classical ultrasound or Doppler flow based analysis has been verified ( 32 ).…”

Section: Methodsmentioning

confidence: 86%

Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

Dai

Sacirovic

et al. 2023

Front. Cardiovasc. Med.

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BackgroundWe investigated the association between leukocyte telomere length, mitochondrial DNA copy number, and endothelial function in patients with aging-related cardiovascular disease (CVD).MethodsIn total 430 patients with CVD and healthy persons were enrolled in the current study. Peripheral blood was drawn by routine venipuncture procedure. Plasma and peripheral blood mononuclear cells (PBMCs) were collected. Cell-free genomic DNA (cfDNA) and leukocytic genomic DNA (leuDNA) were extracted from plasma and PBMCs, respectively. Relative telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) were analyzed using quantitative polymerase chain reaction. Endothelial function was evaluated by measuring flow-mediated dilation (FMD). The correlation between TL of cfDNA (cf-TL), mtDNA-CN of cfDNA (cf-mtDNA), TL of leuDNA (leu-TL), mtDNA-CN of leuDNA (leu-mtDNA), age, and FMD were analyzed based on Spearman's rank correlation. The association between cf-TL, cf-mtDNA, leu-TL, leu-mtDNA, age, gender, and FMD were explored using multiple linear regression analysis.Resultscf-TL positively correlated with cf-mtDNA (r = 0.1834, P = 0.0273), and leu-TL positively correlated with leu-mtDNA (r = 0.1244, P = 0.0109). In addition, both leu-TL (r = 0.1489, P = 0.0022) and leu-mtDNA (r = 0.1929, P < 0.0001) positively correlated with FMD. In a multiple linear regression analysis model, both leu-TL (β = 0.229, P = 0.002) and leu-mtDNA (β = 0.198, P = 0.008) were positively associated with FMD. In contrast, age was inversely associated with FMD (β = −0.426, P < 0.0001).ConclusionTL positively correlates mtDNA-CN in both cfDNA and leuDNA. leu-TL and leu-mtDNA can be regarded as novel biomarkers of endothelial dysfunction.

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Section: Methodsmentioning

confidence: 86%

Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

Dai

Sacirovic

et al. 2023

Front. Cardiovasc. Med.

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Association of endothelial function and lower extremity perfusion in peripheral artery disease

Li,

Dai,

Sacirovic

et al. 2024

Vasa

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Summary: Background: The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD). Patients and methods: In total 229 patients with PAD (Rutherford stage 0–3) were enrolled in the current study. Endothelial function was assessed by measuring flow-mediated dilation (FMD) and endothelial cell proliferation capacity (ECPC). Lower extremity perfusion was assessed by measuring oscillometry-based ankle brachial index (oABI) and pulse wave index (PWI). In addition, carotid intima-media-thickness (cIMT) was also measured as a surrogate marker for atherosclerosis. Correlations between FMD, ECPC, oABI, PWI, and cIMT were analysed using Pearson correlation coefficient. The relationship between the above variables and the severity of PAD was investigated using ordinal logistic regression analysis. Results: Correlation analysis showed that FMD negatively associated with PWI (r = –0.183, p = 0.005), ECPC positively associated with oABI (r = 0.162, p = 0.014), and oABI negatively associated with PWI (r = –0.264, p < 0.001). Ordinal logistic regression analysis showed that ECPC ( β = –0.009, p = 0.048), oABI ( β = -5.290, p < 0.001), and age ( β = −0.058, p = 0.002) negatively associated with the PAD Rutherford stages. In addition, PWI ( β = 0.006, p < 0.001), cIMT ( β = 18.363, p = 0.043) positively associated with the PAD Rutherford stages. Conclusions: Endothelial function significantly associates with lower extremity perfusion in patients with PAD, and both are related to the severity of PAD.

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Assessment of Flow Mediated Dilatation of Brachial Artery by Angiodefender Device as Compared to Brachial Artery Ultrasound Imaging.

Cited by 2 publications

References 20 publications

Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

Association of endothelial function and lower extremity perfusion in peripheral artery disease

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