Assessment of FLUKA, PENELOPE and MCNP6 Monte Carlo codes for estimating gold fluorescence applied to the detection of gold-infused tumoral volumes

Malano, Francisco; Mattea, Facundo; Geser, Federico Alejandro; Pérez, Pedro; Barraco, Daniel E.; Santibáñez, M.; Figueroa, R.; Valente, M.

doi:10.1016/j.apradiso.2019.06.017

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Su nombre es un acrónimo del inglés PENetration and Energy LOss of Positrons and Electrons y el algoritmo se basa en un modelo de dispersión que combina bases de datos numéricas con modelos analíticos de secciones eficaces para los diferentes mecanismos de interacción. Cabe mencionar que el código base PENELOPE ha sido extensa y exitosamente aplicado al estudio de problemas en física de radiaciones y, en particular en física médica [7][8][9][10].…”

Section: Modelo Monte Carlo Basado En Penelopeunclassified

CHARACTERIZATION OF THE XR-100-CdTe AMPTEK SPECTROMETER RESPONSE BY MEANS OF MONTE CARLO SIMULATIONS USING THE PENELOPE CODE

Martín¹,

Haro²,

Valente³

2022

AnAFA

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In recent years, the study of X-ray spectrometry has promoted significant advances in various scientific areas, thus increasing the implementation of ionizing radiation in many applications of modern technology. Typical X-ray spectrometry systems consist of a set of devices that allow this radiation to be converted into a detectable electrical signal. The main spectrometer components include: the sensitive volume (detector), the multichannel pulse processing device, and the associated software. Cadmium telluride (CdTe) has been introduced as a suitable bulk-sensing semiconductor material that reports higher efficiency compared to silicon diodes. Then, the Amptek XR-100T-CdTe spectrometer has gained wide applications during the last years, mainly due to its performance achieving high efficiency up to 100 keV.The present work reports on the characterization of detector response for the Amptek XR using Monte Carlo simulations, while separately accounting for the contribution of the different spectrometer components. To this aim, the geometry along with the elemental composition properties of the different components have been carefully included in the simulation setup. A kernel-based approach has been implemented to study the response of the detector using narrow monoenergetic X-ray beams having incident kinetic energy within [5-1000] keV, and discriminating the relative contribution for each kernel attributable to the different spectrometer components. Finally, the simulation results have been compared with the efficiency curve reported by the manufacturer, showing good agreement with the kernel based approach characterization when the CdTe sensitive volume along with the Be vacuum window are taken into account.

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Section: Modelo Monte Carlo Basado En Penelopeunclassified

CHARACTERIZATION OF THE XR-100-CdTe AMPTEK SPECTROMETER RESPONSE BY MEANS OF MONTE CARLO SIMULATIONS USING THE PENELOPE CODE

Martín¹,

Haro²,

Valente³

2022

AnAFA

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“…These discrepancies could be due to the variations between Gate and PenRed in the implementation of the physics models, transport algorithms and the material database. Indeed, discrepancies between different Monte Carlo codes have been reported in the literature, specially when electron transport is involved [37], [38], [39], [40]. Finally, figure 8 shows the dose distributions for two Z planes generated by PenRed (left) and GATE (right).…”

Section: Dicom Testsmentioning

confidence: 99%

PenRed: An extensible and parallel Monte-Carlo framework for radiation transport based on PENELOPE

Giménez-Alventosa

Gómez

Oliver

2021

Computer Physics Communications

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“…Previous works [49][50][51] have demonstrated the feasibility of the technique here proposed. Furthermore, aimed at validating the methodology along with prototype design, dedicated Monte Carlo simulation tools 52,53 have been developed and implemented. The prototype design has been optimized in terms of SNR and dosimetry outputs adjusting collimation system design and the overall configuration.…”

Section: Introductionmentioning

confidence: 99%

OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

et al. 2021

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A novel and suitable energy‐dispersive X‐ray fluorescent (EDXRF) device, currently at the prototype stage, the Project OXIRIS (Orthovoltage X‐Ray–Induced Radiation System), is presented for the simultaneous detection and treatment of cancer diseases. Monte Carlo simulation and experimental results of EDXRF signals from a small deep artificial tumor consisting of a solution of gold nanoparticles bio‐targeted and immersed in a tissue‐bioequivalent matrix are presented and compared. Briefly, the device consists of a dynamic orthovoltage X‐ray fluence concentration coupled to confocal with an EDXRF system along with a sample holder for 3D scanning; all integrated and controlled by a dedicated software capable of controlling the whole operation functionalities: the X‐ray source, the rotating arm, the sample holder, and the detection system. The software also includes dedicated subroutines for X‐ray fluorescent spectra processing to correlate K‐lines signal at each acquisition position with the corresponding high atomic number elements' concentration to produce a 3D distribution according to the user‐defined grid. The confocal configuration ensures that the detected signal comes exclusively from the excited volume as defined by the bulk of the focal spot. Hence, the 3D image is achieved by scanning the sample holder through the movement of the sample‐carrier stretcher moved by step motors in the 3 coordinated axes. The feasibility of the proposed methodology and the design of the prototype have been successfully demonstrated experimentally, targeting gold nanoparticles in water‐equivalent phantoms.

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Assessment of FLUKA, PENELOPE and MCNP6 Monte Carlo codes for estimating gold fluorescence applied to the detection of gold-infused tumoral volumes

Cited by 7 publications

References 31 publications

CHARACTERIZATION OF THE XR-100-CdTe AMPTEK SPECTROMETER RESPONSE BY MEANS OF MONTE CARLO SIMULATIONS USING THE PENELOPE CODE

CHARACTERIZATION OF THE XR-100-CdTe AMPTEK SPECTROMETER RESPONSE BY MEANS OF MONTE CARLO SIMULATIONS USING THE PENELOPE CODE

PenRed: An extensible and parallel Monte-Carlo framework for radiation transport based on PENELOPE

OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

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