Assessment of frailty in cirrhosis using bedside measures and its correlation with Child-Turcotte-Pugh, MELD &amp; MELD-Na Scores

Zuberi, Bader Faiyaz; Rasheed, Tazeen; Ali, Faiza Sadaqat; Bader, Nimrah; Sadaf, Rabia

doi:10.12669/pjms.38.5.5545

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…The Child-Turcotte-Pugh (CTP)[ 24 ] scoring system was used as a clinical classification standard to quantitatively assess liver reserve function in patients with LC.…”

Section: Methodsmentioning

confidence: 99%

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

Hu,

Ding,

Liu

et al. 2024

World J Gastroenterol

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BACKGROUND Hepatitis B cirrhosis (HBC) is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction. Although the relationship between certain single probiotics and HBC has been explored, the impact of the complex ready-to-eat Lactobacillus paracasei N1115 (LP N1115) supplement on patients with HBC has not been determined. AIM To compare the changes in the microbiota, inflammatory factor levels, and liver function before and after probiotic treatment in HBC patients. METHODS This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December 2020. Patients were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment only. Fecal samples were collected at the onset and conclusion of the 12-wk intervention period. The structure of the intestinal microbiota and the levels of serological indicators, such as liver function and inflammatory factors, were assessed. RESULTS Following LP N1115 intervention, the intestinal microbial diversity significantly increased in the intervention group (P < 0.05), and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful bacteria. Additionally, the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors (P < 0.05). CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.

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“…The Child-Turcotte-Pugh (CTP)[ 24 ] scoring system was used as a clinical classification standard to quantitatively assess liver reserve function in patients with LC.…”

Section: Methodsmentioning

confidence: 99%

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

Hu,

Ding,

Liu

et al. 2024

World J Gastroenterol

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“…Fraility is as an age-related syndrome characterized by unintended loss of weight, tiredness, weakness, slow gait, and reduced physical activity. 6 Since the functional decline associated with frailty can be delineated by the morphological or quantitative change of sarcopenia, several researchers consider sarcopenia as an indicator of preoperative frailty. 7 Indeed, sarcopenia is now a recognized condition characterized by a progressive and generalized loss of skeletal muscle mass and strength.…”

Section: Introductionmentioning

confidence: 99%

Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis

Chen¹,

Xia²,

Liu³

et al. 2023

Pak J Med Sci

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Objective: This meta-analysis was designed to assess if pre-operative low skeletal muscle mass impacts mortality rates of patients undergoing abdominal aortic aneurysm (AAA) repair. Methods: Datasets of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched from 1st January 1980 to 15th December 2021 for studies assessing the role of low skeletal muscle mass on mortality rates of AAA repair. Studies measuring skeletal muscle mass on computed tomography scans and reporting long-term mortality (>1 year) were included. Multivariable adjusted ratios were combined in a random-effects model. Results: Fifteen studies with 3776 patients were included. Meta-analysis showed a statistically significant increased risk of all-cause mortality in patients with low skeletal muscle mass (HR: 2.07 95% CI: 1.56, 2.74 I2=65% p<0.00001) as compared to normal muscle mass patients. Pooled data indicated that low skeletal muscle mass was associated with statistically significant increased risk of mortality in studies on endovascular repair (HR: 2.86 95% CI: 1.95, 4.20 I2=58% p<0.00001) as well as those including a mixed group of patients (HR: 1.39 95% CI: 1.06, 1.82 I2=31% p=0.02). Conclusion: Low skeletal muscle mass in AAA patients undergoing surgical repair is associated with increased risk of long-term mortality. Current evidence is limited by the retrospective nature of data and variability in defining and measuring low skeletal muscle mass. There is a need for future prospective studies defining the optimal cut-off of low skeletal muscle mass in different populations. doi: https://doi.org/10.12669/pjms.39.2.7366 How to cite this: Chen J, Xia Y, Liu Y, Zhu H. Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7366 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prognosis of the clinical course of portal hypertension complicated by the acute variceal bleeding

Kedyk¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Variceal bleeding is one of the most dangerous complications of liver cirrhosis, which is associated with relatively high lethality. At the same time, the bleeding can trigger some other complications of liver cirrhosis that further worsen the prognosis for these patients. These factors determine the necessity not only for the diagnosis of variceal bleeding in patients with liver cirrhosis but also for the prognosis of possible recurrent bleeding and lethality. The aim of this study was to evaluate the possibility of predicting survival or lethality in patients with variceal bleeding. This study is based on the results of the investigation and treatment of 121 patients with liver cirrhosis complicated by variceal bleeding. To determine the prognostic value of the clinical course, the analysis of various markers of complete blood count, biochemical blood and coagulation markers, Child-Turcotte-Pugh and MELD criteria was performed. The ROC (receiver operating characteristic) curve was applied for the evaluation and comparison of various markers. Additionally, the specificity, sensitivity, accuracy, positive (PPV) and negative prognostic value (NPV), positive (LR+) and negative (LR-) likelihood ratio were used. The J-index (index Youden) was applied for the comparison of border values. Predicting the clinical course allows for identifying patients with a possible unfavorable prognosis who require intensive therapy, as well as those with minimal risk of fatal outcome. According to the study results, the International normalized ratio (sensitivity – 95%, specificity – 97%), potassium blood level (sensitivity – 95.2%, specificity – 89%), and MELD score (sensitivity – 95.2%, specificity – 86%) are the markers, which had the highest prognostic value for the unfavorable clinical course. Whereas the sodium blood level (sensitivity – 96%, specificity – 100%) was the best marker of favorable clinical course. Other analyzed indicators had limited prognostic significance. Thus, although the number of bleedings in the anamnesis increases the risk of a fatal outcome, it has limited importance for prognostics of a favorable or unfavorable course of variceal bleeding. The sodium blood level is the best marker for the prediction of a favorable clinical course. International normalized ratio, potassium blood level, and MELD score are the markers of an unfavorable clinical course.

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Assessment of frailty in cirrhosis using bedside measures and its correlation with Child-Turcotte-Pugh, MELD & MELD-Na Scores

Cited by 3 publications

References 22 publications

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

Effect of low skeletal muscle mass on long-term mortality after abdominal aortic aneurysm repair: A meta-analysis

Prognosis of the clinical course of portal hypertension complicated by the acute variceal bleeding

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