Many irradiation experiments performed in research reactors are used to assess the effects of nuclear radiations on material or fuel sample properties, and are therefore a crucial stage in most qualification and innovation studies regarding nuclear technologies. However, monitoring these experiments requires accurate and reliable instrumentation. Among all measurement systems implemented in irradiation devices, temperature-and more particularly high-temperature (above 1000 • C)-is a major parameter for future experiments related, for example, to the Generation IV International Forum (GIF) Program or the International Thermonuclear Experimental Reactor (ITER) Project. In this context, the French Commissariat à l'Energie Atomique (CEA) develops and qualifies innovative in-pile instrumentation for its irradiation experiments in current and future research reactors. Logically, a significant part of these research and development programs concerns the improvement of in-pile hightemperature measurements. This article describes the development and qualification of innovative high-temperature thermocouples specifically designed for in-pile applications. This key study has been achieved with technical contributions from the Thermocoax Company. This new kind of thermocouple is based on molybdenum and niobium thermoelements, which remain nearly unchanged by thermal neutron flux even under harsh nuclear environments, whereas typical high-temperature thermocouples such as Type C or Type S are altered by significant drifts caused by material transmutations under the same conditions. This improvement has a significant impact on the temperature measurement capabilities for future irradiation experiments. Details of the successive stages of this development are given, including the results of prototype qualification tests and the manufacturing process.