Assessment of Genetic Damage in Coal Miners of Punjab, Pakistan

Background. In the air of an industrial environment associated with the processing and combustion of coal contains a huge amount of coal dust, heavy metals, polycyclic aromatic hydrocarbons, which have a negative impact on genetic stability. In this regard, the purpose of the study is to study the genotoxic effects in workers of coal thermal power plants. Materials and methods. The paper presents a cytogenetic analysis of genomic damage in 455 coal-fired thermal power plant workers compared with 533 control donors from Kemerovo using a micronucleus test. The formation of genomic abnormalities in coal-fired thermal power plant workers was assessed in relation to sex, age, smoking status, presence of chronic diseases, length of service, and working shops. Results. A significant increase in the frequency of occurrence of lymphocytes with micronuclei, nucleoplasmic bridges, nuclear buds, as well as cells at the stage of apoptosis in workers of coal-fired thermal power plants compared to the control group was established. An increase in the frequency of occurrence of cells with cytogenetic disorders was revealed in women working in coal production and workers over 51 years of age. Work experience and professional specialization had a significant impact on the formation of genomic disorders. Conclusion. The obtained results indicate a significant contribution of environmental factors to the development of geno- and cytotoxic effects in workers of coal-fired thermal power plants.

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Quantification of Heavy Metals and Chemical Stressors in Ground Water of Coal Mining Areas and Associated Human Health Risk

Batool,

Idrees,

Khannum

et al. 2023

PJHS

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Acid mine drainage is one of the most obvious challenges in coal mining areas that is responsible for deteriorating soil and ground water quality of nearby communities thus posing serious human health risk. Objective: To quantify of heavy metals and chemical stressors in ground water and associated human health risk. Methods: Cross-sectional study with a combination of random sampling and Probability-Proportional-to-Size Sampling was used. Eight different sites were selected for water sample collection, and heavy metals were quantified. The analysis was carried out. Physicochemical properties of water were assessed using a portable photometer. Hematological parameters and antioxidants in the blood of study subjects were also measured. Results: Among the water samples, site S1 had the highest iron concentration at 0.354 ppm, exceeding the US limit of 0.3 ppm, with nickel being the next most abundant metal. Site S8 recorded the highest temperature at 36.4°C, while site S5 had the highest pH in the drinking water. The maximum electrical conductivity was found at S4 with 1387 s/m, and the total dissolved solvent parameter peaked at 1598 ppm in S8. Subjects exposed to acid mine drainage through water consumption displayed significant changes in antioxidant and blood parameters compared to the control group. In the exposed group, catalase (63.47), superoxide dismutase (33.26), and glutathione peroxidase (532.97) levels decreased, while malondialdehyde levels increased to 1.39. Conclusions: The physical and chemical properties of all water resources of mining areas were negatively altered due to heavy metals contamination thus poses a serious threat of oxidative stress in exposed subjects.

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Assessment of Genetic Damage in Coal Miners of Punjab, Pakistan

Cited by 3 publications

References 26 publications

Comment on the paper “Assessment of Genetic Damage in Coal Miners of Punjab, Pakistan” by Idrees et al.

Comment on the paper “Assessment of Genetic Damage in Coal Miners of Punjab, Pakistan” by Idrees et al.

Analysis of cytogenetic disorders in residents of an industrial region in connection with work at coal-fired thermal power plants

Quantification of Heavy Metals and Chemical Stressors in Ground Water of Coal Mining Areas and Associated Human Health Risk

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