Assessment of Ginger Extract and Ginger Nanoparticles Protective Activity against Acetaminophen-Induced Hepatotoxicity and Nephrotoxicity in Rats

Bakr, Alaa F.

doi:10.29261/pakvetj/2019.060

Cited by 24 publications

(21 citation statements)

References 17 publications

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“…Thimerosal administration results in an increased TBARS level in doctored rats, that is in line with the increase in TBARS in the head and body of flies treated with thimerosal ( Bianchini et al, 2019 ). Natural antioxidants containing plant extracts have shown useful curative abilities against chemically persuaded damages ( Bakr et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A study on the potential reprotoxic effects of thimerosal in male albino rats

Ijaz

Batool²,

Ashraf

et al. 2020

Saudi Journal of Biological Sciences

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Thimerosal is ethyl mercury based compound which is being used as a preservative in vaccines since decades. Pharmaceutical products and vaccines that contain thimerosal are among the potential source of mercury exposure. Current research was intended to ascertain the reprotoxic effects of thimerosal on rat testes. Twenty-four adult male albino rats were sorted into four groups (n = 6). The first group was a control group. Rats of experimental Group 2, 3 and 4 were treated with various dosages of thimerosal (0.5, 10, 50 mg/kg) respectively. Rats were decapitated after thirty days of trial and different parameters were analyzed. Thimerosal exposure resulted in a significant decrease in antioxidant enzyme activities including catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), glutathione reductase (GSR) and increased levels of thiobarbituric acid reactive substances (TBARS). Different doses of thimerosal significantly decreased (p < 0.05) the concentration of plasma testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH). Additionally, Daily sperm production (DSP) and efficiency of daily sperm production were significantly reduced followed by thimerosal exposure. Moreover, thimerosal significantly (p < 0.05) decreased the primary spermatocytes, secondary spermatocytes, number of spermatogonia along with spermatids. Thimerosal induced adverse histopathological and morphological changes in testicular tissues such as decreased Leydig cells, diameter of seminiferous tubules, tunica albuginea height and epithelial height. On the other hand, the increase in tubular lumen and interstitial spaces was observed due to thimerosal. These outcomes indicated that thimerosal has potential reprotoxic effects in male albino rats.

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Section: Discussionmentioning

confidence: 99%

A study on the potential reprotoxic effects of thimerosal in male albino rats

Ijaz

Batool²,

Ashraf

et al. 2020

Saudi Journal of Biological Sciences

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“…Ginger (Zingiber officinale Roscoe), an indigenous plant in tropical Asia and probably in southern China and India, has a long life, cane-like plant with annual leafy stalks (Hassan & Hassan, 2018). The pharmacological properties of ginger are attributed to its active ingredients such as gingerols and shogaols, which Thus, in our in vitro study we assessed the hepatoprotective properties of isolating ginger nanoparticles relative to ginger extract using acetaminophen as a hepatotoxic compound and compare the results with our previous in vivo study (Bakr et al, 2019), to examine the possibility of using GNPs in drug delivery without causing any side effects.…”

Section: Introductionmentioning

confidence: 99%

Cytological Study on Rat Isolated Hepatocytes and Possible Protection of Ginger (Extract and Nanoparticles) Against Acetaminophen Toxicity

Abdelgayed¹,

Bakr²,

El-Tawil³

et al. 2021

J microb biotech food sci

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Ginger is one of most important medicinal plants which used in variable diseases. Recently, ginger nanoparticles have been isolated from ginger extract and exhibited anti-apoptotic activity, hepatoprotective effect against alcohol and may effectively reduce colitis. Our study aimed to compare between the effect of ginger extract and ginger nanoparticles at concentration of 60 µg/ml against hepatotoxicity caused by acetaminophen (APAP; N-acetyl-para-aminophenol) at concentration of 0.1 mg/ml using primary isolated rat hepatocytes. Cytotoxicity was determined by assessing cell viability and leakage of cytosolic enzymes, such as (ALT& AST). Oxidative stress was investigated by measuring levels of MDA and catalase enzymes. The cytopathological lesions were detected by light microscope. Exposure of isolated rat hepatocytes to APAP caused cytotoxicity and oxidative injury, manifested by loss of cell viability and significant increase of enzymes leakages. Also, APAP caused progressive depletion of catalase content and increase in intracellular MDA accumulation, in addition to alteration in histological structures of the cells. Pretreatment of hepatocytes with either GE or GNPs ameliorated the hepatotoxicity, oxidative stress and enzymatic leakage induced by APAP. However, GNPs were more effective compared to ginger extract pre-treated hepatocytes.

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“…So, in matter of achieving success in controlling this severe disease other options and protocols are effectively used in different countries of world (Zhang et al, 2018;Bakr et al, 2019;Sarwar et al, 2019). Among other options plant-derived compounds and their products have shown better anticoccidial effects (Gadelhaq et al, 2018;Farieha et al, 2019;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

In vitro anticoccidial activity of Vitis vinifera extract on oocysts of different Eimeria species of Broiler Chicken

Abbas¹,

Abbas

Iqbal

et al. 2020

J Hellenic Vet Med Soc

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In the current experiment, the in vitro anticoccidial effect of Vitis venifera (grape seed) extract was evaluated. For this purpose, an in vitro sporulation inhbition assay was used. Collected oocysts of four Eimeria species (E. tenella, E. necatrix, E. brunetti and E. mitis) were exposed to six different concentrations (w/v) of Vitis vinifera extract (VVE) in 10% Dimethylsulphoxide solution (DMSO), while Dimethylsulphoxide (DMSO) and Potassium dichromate solution (K2Cr2O7) served as control groups. The results of the present study revealed that V. vinifera extract showed inhibitory effect on sporulation (%) and damage (%) of Eimeria oocysts in a dose dependent manner as compared to both control groups. V. vinifera extract also damaged the morhology of oocysts in terms of shape, size and number of sporocysts.

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Assessment of Ginger Extract and Ginger Nanoparticles Protective Activity against Acetaminophen-Induced Hepatotoxicity and Nephrotoxicity in Rats

Cited by 24 publications

References 17 publications

A study on the potential reprotoxic effects of thimerosal in male albino rats

A study on the potential reprotoxic effects of thimerosal in male albino rats

Cytological Study on Rat Isolated Hepatocytes and Possible Protection of Ginger (Extract and Nanoparticles) Against Acetaminophen Toxicity

In vitro anticoccidial activity of Vitis vinifera extract on oocysts of different Eimeria species of Broiler Chicken

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