Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction using 2-dimensional strain imaging

Abstract

The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular (LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their ejection fraction (EF) values (group A: LVEF≥50%; group B: LVEF < 50%), and 35 normal people served as the control group. Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26AE1.89 vs 10.74AE2.67; 9.71AE1.71 vs 11.36AE2.29, both P < 0.05), but the radial displacement and global twist were maintained (P > 0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly, especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both P < 0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification of left ventricular global and segment twist and radial displacement in patients with coronary artery disease.

Quantitative MRI biomarkers to characterize regional left ventricular perfusion and function in nonhuman primates during dobutamine-induced stress: A reproducibility and reliability study

“…Changes in underlying myocyte stiffness may thus be reflected through changes in the areas under the torsion‐strain loops. Previous publications have shown alterations in twist displacement loops for various pathological conditions . During the early stage of the disease, when resting function is normal, these alterations in the ECM collagen content and in the myocyte stiffness may manifest as functional abnormalities under conditions of stress.…”

“…Previous publications have shown alterations in twist displacement loops for various pathological conditions. 34,35 During the early stage of the disease, when resting function is normal, these alterations in the ECM collagen content and in the myocyte stiffness may manifest as functional FIGURE 6: a: Bland-Altman plots for functional and perfusion biomarkers computed at rest and during stress. The x-axis represents the mean((test1retest)/2), while the y-axis represents the difference(test-retest).…”