2020
DOI: 10.3390/s20133678
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Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms

Abstract: The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarker… Show more

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Cited by 15 publications
(19 citation statements)
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“…This represents a homogeneous layer of densely packed biorecognition elements, which provides a highly packed transducing surface for the interaction with the target species. [47] The response registered for the antibody coverage in this study was comparable with those reported in the literature, with equivalent working conditions, for which an angular response of Δθ SPR % 0.18 was recorded. [51,52] The error bars have been estimated as the relative standard deviation of the surface coverages on two different replicates and four different sampled areas, to provide an estimation of the homogeneity of the biolayer uniformity.…”
Section: Specificationsupporting
confidence: 88%
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“…This represents a homogeneous layer of densely packed biorecognition elements, which provides a highly packed transducing surface for the interaction with the target species. [47] The response registered for the antibody coverage in this study was comparable with those reported in the literature, with equivalent working conditions, for which an angular response of Δθ SPR % 0.18 was recorded. [51,52] The error bars have been estimated as the relative standard deviation of the surface coverages on two different replicates and four different sampled areas, to provide an estimation of the homogeneity of the biolayer uniformity.…”
Section: Specificationsupporting
confidence: 88%
“…This represents a homogeneous layer of densely packed biorecognition elements, which provides a highly packed transducing surface for the interaction with the target species. [ 47 ]…”
Section: Resultsmentioning
confidence: 99%
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“…Therefore, under these assumptions, and by including Equation (2) in Equation ( 1), the surface coverage Γ can be expressed as a function of the experimental angular shift (∆θ SPR , deg) [7,30]:…”
Section: Gold Layer Bio-modificationmentioning
confidence: 99%
“…Many efforts have been made to study suitable immobilization techniques of biorecognition elements on metal surfaces [5][6][7][8]. Some advantages may arise from the stable anchoring of biomolecules by covalent immobilization by forming chemical bonds between complementary functional groups present on the biomolecules and on the solid surface, compared to their direct adsorption on sensor surfaces [3].…”
Section: Introductionmentioning
confidence: 99%