Assessment of Graded Intestinal Hypoperfusion and Reperfusion Using Continuous Saline Tonometry in a Porcine Model

Abstract

Continuous saline tonometry detected intestinal ischemia as induced by graded reductions in IPP. A threshold could be defined above which intestinal ischemia does not occur.

Effects of simulated hypovolaemia on haemodynamics, left ventricular function, mesenteric blood flow and gastric Pco2

“…On the basis of the available evidence (28–31), we conclude that the degree of mesenteric hypoperfusion attained in our subjects (–38%), associated with a decrease in CO by 33%, was insufficient to induce gastric mucosal acidosis and a measurable increase in P g co 2 . However, this contrasts with the reported increase in P g co 2 and the P co 2 gap in volunteers in whom up to 25% of the estimated blood volume was progressively withdrawn (9).…”

Temporary Prosthetic Shunt to Permanent Aortic Prosthesis in a Patient with an Infected Thoracoabdominal Aneurysm to Shorten Ischemia Time~!2010-04-04~!2010-06-03~!2010-07-26~!

“…Portal hypertension also may have reduced collateral intestinal perfusion, thus aggravating the clampinduced ischemia. With a mean BP of 50 mm Hg, an abdominal pressure of 10 cm H 2 O, a CVP of 1-3 mm Hg, and a portal venous pressure of 5-10 mm Hg, intestinal perfusion pressure could have been in the range of 30-37 mm Hg, which may not be enough to maintain aerobic metabolism [12]. Aerobic metabolism may be essential in the period after clamp ischemia to allow restitution of the ischemic intestines.…”

Isquemia mesentérica e reposição do volume intravascular. Estudo comparativo entre duas soluções salinas com diferentes concentrações de cloreto de sódio nos eventos desencadeados pela reperfusão intestinal. Um modelo experimental em ratos

“…Como vimos, essa condição inicial pode ser considerada uma situação de hipervolemia relativa para o sistema circulatório (KHANNA et al, 2001). A exclusão de um extenso território visceral da circulação arterial leva a ajustes no sistema cardiocirculatório para acomodar o volume intravascular e o débito cardíaco a essa nova situação de diminuição de território a ser irrigado (FROJSE et al, 2004). Na situação oposta, após a liberação da artéria mesentérica superior, encontramos um menor volume intravascular para a perfusão da extensa área previamente excluída.…”