Assessment of greenness for the determination of voriconazole in reported analytical methods

Chanduluru, Hemanth Kumar; Sugumaran, Abimanyu

doi:10.1039/d1ra08858k

Cited by 24 publications

(9 citation statements)

References 108 publications

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“…Test tablets are considered bioequivalent to Dostinex tablets and could be approved as a good substitute for the generic product. Estimation for the greenness of the proposed LC/MS/MS method AGREE approach is simple and reliable for the assessment of eco-friendly characters of the analytical method [19,21,[36][37][38][39][40][41][42][43]. The final greenness numerical value was 0.63 with a relatively pale green color inside the pictogram as demonstrated in Additional file 1: Fig.…”

Section: Results Of Pharmacokinetic Parametersmentioning

confidence: 96%

A validated LC–MS/MS method for analysis of Cabergoline in human plasma with its implementation in a bioequivalent study: investigation of method greenness

et al. 2022

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Cabergoline (CAB) is effective prolactin lowering drug. Evaluation of the bioequivalence for the new test product (0.5 mg CAB film-coated tablets) in Egypt is strongly needed for approval of the drug by the official health authority. Therefore, a highly sensitive and rapid (LC–MS/MS) method was validated for CAB analysis in human plasma. CAB was extracted from plasma via diethyl ether using Quetiapine (QUE) as an internal standard. Multiple reaction monitoring (MRM) in positive ion mode was used, m/z 452.3 → 381.2 for CAB and 384.2 → 253.1 for QUE. Separation was accomplished on a reversed-phase C18. FDA procedures for the bio-analytical method were followed. The method was used in the bioequivalence study to compare the test product (0.5 mg CAB) versus Dostinex tablets, on 24 healthy Egyptian volunteers. The total analysis time was 5.5 min for each sample which permits analysis of various samples per day. The linearity range was from 2.00 to 200.00 pg/mL for CAB. LOD and LOQ were found to be 0.5 and 1.6 pg/mL, respectively. The final greenness numerical value was 0.63 using AGREE tool. The results of pharmacokinetic parameter Tmax were 2.17, and 2.33 h; for test and reference products, respectively. The generic formulation of test product is considered bioequivalent to the reference product Dostinex 0.5 mg tablets and satisfies the requirements of the Egyptian market. The merits of the method over the previous published methods are low cost; availability of cheap internal standard; rapidness; use of acetonitrile-free solvents mobile phase.

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Section: Results Of Pharmacokinetic Parametersmentioning

confidence: 96%

A validated LC–MS/MS method for analysis of Cabergoline in human plasma with its implementation in a bioequivalent study: investigation of method greenness

et al. 2022

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“…AGREE and GAPI analytical greenness approaches are dependable, simple and automated tools for evaluating an analytical method’s greenness (Chanduluru & Sugumaran, 2022; Gamal, Naguib, Panda, & Abdallah, 2021; Kannaiah & Sugumaran, 2022; Pena‐Pereira et al, 2020; Płotka‐Wasylka, 2018; Płotka‐Wasylka & Wojnowski, 2021; Sajid & Płotka‐Wasylka, 2022; Wojnowski et al, 2022). The overall AGREE score of 0.63 in Figure 5 denotes the satisfactory eco‐friendliness of the proposed method.…”

Section: Resultsmentioning

confidence: 99%

LC–MS/MS approach for simultaneous assessment of hyoscine N‐butyl bromide and ketoprofen in biological fluids and pharmaceuticals

Ali

Alsohaimi

Hasanin

et al. 2023

Biomedical Chromatography

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“…A more accurate estimate of greenness is provided by the GAPI, a relatively new comprehensive tool. A software application called AGREE that covers all 12 GAC principles produce numerical results with a high of 1 indicating complete greenness and a decreasing number indicating less greenness [34,35,40,41].…”

Section: Greenness Assessmentmentioning

confidence: 99%

“…These tools were largely based on those 12 principles. The primary factors that were found to have an impact on the greenness of chromatographic techniques were waste production, the use of nongreen or bio-accumulative solvents, and sample preparation [34,35].…”

Section: Introductionmentioning

confidence: 99%

High‐performance thin layer chromatographic method development and validation for simultaneous estimation of solifenacin succinate and silodosin using quality by design approach and greenness assessment

Lodha,

Pillai,

Kalyankar

et al. 2023

Separation Science Plus

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The current research developed a high‐performance thin layer chromatographic method based on green analytical chemistry and integrated experimental approaches of analytical quality by design for simultaneous estimation of solifenacin succinate and silodosin. The integration was planned to reduce energy and solvent usage, maximize efficacy, and minimize any negative environmental effects. Taguchi design for screening and optimization a Box–Behnken design was used. The n‐butanol:ethanol:triethylamine (6:4:0.1, v/v/v) mobile phase and ultraviolet detection at 221 nm were used to develop the method. As per International Council for Harmonization Q2(R1) specifications, the method was validated. Rf value for solifenacin succinate and silodosin was found to be 0.29 ± 0.02 and 0.58 ± 0.02 respectively. For solifenacin succinate and silodosin, the linearity was found over the concentration ranges of 500–2500 ng/band and 800–4000 ng/band. For solifenacin succinate, the limits of detection and quantification were found to be 13.00 and 39.34 ng/band, respectively, while for silodosin, they were 33.29 and 100.86 ng/band, respectively. For solifenacin succinate, the method revealed a percent recovery ranging from 98.49% to 99.50%, while for silodosin, it exhibited a range from 98.86% to 99.79%. The tools predicted greenness score to be 63 and 0.78, respectively, indicating the proposed method to be green.

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Assessment of greenness for the determination of voriconazole in reported analytical methods

Abstract: This report assessed the greenness profiles of various determination methods for voriconazole in bulk and pharmaceutical dosage forms using various assessment tools. The types of solvents utilized in the analysis were examined as well.

Cited by 24 publications

References 108 publications

A validated LC–MS/MS method for analysis of Cabergoline in human plasma with its implementation in a bioequivalent study: investigation of method greenness

A validated LC–MS/MS method for analysis of Cabergoline in human plasma with its implementation in a bioequivalent study: investigation of method greenness

LC–MS/MS approach for simultaneous assessment of hyoscine N‐butyl bromide and ketoprofen in biological fluids and pharmaceuticals

High‐performance thin layer chromatographic method development and validation for simultaneous estimation of solifenacin succinate and silodosin using quality by design approach and greenness assessment

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