Assessment of HDR brachytherapy-replicating prostate radiotherapy planning for tomotherapy, cyberknife and VMAT

Chavez, R; Grogan, Garry; Hug, Ben; Howe, Kate; Grigg, Alice; Waterhouse, David; Lane, Jonathan A.; Glyde, Alan; Brown, Elizabeth; Bydder, Sean; Pryor, David; Hargrave, Catriona; Charles, Paul; Hellyer, James; Ebert, Martin A.

doi:10.1016/j.meddos.2021.08.003

Cited by 3 publications

(3 citation statements)

References 22 publications

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Section: Discussionmentioning

confidence: 99%

“…For the delivery of SBRT, there are several radiation techniques used to deliver a large-fraction dose to the prostate [ 27 , 28 , 29 , 30 ]. RT modality, as provided by the robot-assisted technique Cyber Knife ® (CK), which can deliver such radiation within a high-fraction dose, is currently witnessing increased usage in the treatment of prostate cancer with low to intermediate risk [ 27 , 28 , 29 , 30 ]. IMRT techniques, including rotational approaches as helical tomotherapy and volumetric modulated arc therapy (VMAT), can also deliver a high daily fraction with high conformity and reduce the dose to the surrounding healthy tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al reported that, based on physical dosimetry and radiobiologic considerations, helical tomotherapy may have advantages over CK, specifically in rectal sparing, which could translate into the clinical benefit of decreased late toxicities [ 30 ]. The series of studies showing good dosimetric quality for several SBRT techniques for the treatment of localized prostate cancer was demonstrated [ 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Ultrahypofractionated Radiotherapy versus Conventional to Moderate Hypofractionated Radiotherapy for Clinically Localized Prostate Cancer

Yamazaki

Suzuki

Aibe

et al. 2021

Cancers

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The purpose of this study was to compare the toxicity (first endpoint) and efficacy (second endpoint) of ultrahypofractionated radiotherapy (UHF) and dose-escalated conventional to moderate hypofractionated radiotherapy (DeRT) for clinically localized prostate cancer. We compared 253 patients treated with UHF and 499 patients treated with DeRT using multi-institutional retrospective data. To analyze toxicity, we divided UHF into High-dose UHF (H-UHF; equivalent doses of 2 Gy per fraction: EQD2 > 100 Gy1.5) and low-dose UHF (L-UHF; EQD2 ≤ 100 Gy1.5). In toxicity, H-UHF elevated for 3 years accumulated late gastrointestinal and genitourinary toxicity grade ≥ 2 (11.1% and 9.3%) more than L-UHF (3% and 1.2%) and DeRT (3.1% and 4.8%, p = 0.00126 and p = 0.00549). With median follow-up periods of 32.0 and 61.7 months, the actuarial 3-year biochemical failure-free survival rates were 100% (100% and 100% in the L-UHF and H-UHF) and 96.3% in the low-risk group, 96.5% (97.1% and 95.6%) and 94.9% in the intermediate-risk group, and 93.7% (100% and 94.6%) and 91.7% in the high-risk group in the UHF and DeRT groups, respectively. UHF showed equivocal efficacy, although not conclusive but suggestive due to a short follow-up period of UHF. L-UHF using EQD2 ≤ 100 Gy1.5 is a feasible UHF schedule with a good balance between toxicity and efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrahypofractionated Radiotherapy versus Conventional to Moderate Hypofractionated Radiotherapy for Clinically Localized Prostate Cancer

Yamazaki

Suzuki

Aibe

et al. 2021

Cancers

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Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer

Song,

Chen,

et al. 2024

Eur J Med Res

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Background Stereotactic body radiation therapy (SBRT) has been widely used for pancreatic cancer. However, there is still a lack of studies comparing the latest SBRT techniques in terms of clinical efficacy and safety. Objectives: This study aims to evaluate three latest SBRT delivery platforms: CyberKnife (CK), Tomography Radixact (TOMO), and Halcyon volume rotation intensity modulation therapy (VMAT) for the treatment of pancreatic cancer. Methods Sixteen patients with pancreatic cancer treated with CK were retrospectively analyzed. SBRT plans were designed using Precision and Eclipse software. CK plans were optimized in two forms: fixed collimator (CK-Fixed) and multi-leaf grating collimator (CK-MLC). TOMO plans were designed with 2.5 cm Fixed Jaw, pitch 0.123–0.43 and 4.0 modulation factors in precision system. In Eclipse 15.6 system, photon optimizer (OP) algorithm was used to design the coplanar two-arc Halcyon VMAT. The median radiation dose was 40 Gy (35–45 Gy) in 5 fractions. The effectiveness of clinical treatment was evaluated by comparing the homogeneity index ( HI ), conformity index ( CI ), coverage of the planning target volume (PTV) and dose distribution parameters of organs at risk (OAR). Results All plans met the limits of clinical target dose and OAR. CK-MLC plans had the lowest maximum dose of 2 cm normal tissue from PTV margin (D 2cm ), indicating a low risk of peripheral radiation damage. Additionally, the CK-MLC plans had the lowest dose parameters and provided the best protection for the kidney, spinal cord, small intestine, and duodenum, with a paired t-test p < 0.05, indicating a statistical difference. Conclusion High conformity and adjustability of CK-MLC allowed for precise complex target localization and conformal dose distribution, benefiting tumor treatment while maximally reducing damage to OAR. This study provides valuable dosimetric evidence for SBRT technique selection for pancreatic cancer.

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Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer

Song,

Chen,

Wang

et al. 2024

Preprint

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Background Stereotactic body radiation therapy (SBRT) has been widely used for pancreatic cancer. However, there is still a lack of studies comparing the latest SBRT techniques in terms of clinical efficacy and safety. Objectives: This study aimed to evaluate three latest SBRT elivery platforms: CyberKnife (CK), Tomography Radixact (TOMO), and Halcyon volume rotation intensity modulation therapy (VMAT) for the treatment of pancreatic cancer. Methods Sixteen patients with pancreatic cancer treated with CK were retrospectively analyzed. SBRT plans were designed using Precision and Eclipse software. CK plans were optimized in two forms: fixed collimator (CK-Fixed) and multi-leaf grating collimator (CK-MLC). The median radiation dose was 40 Gy (35–45 Gy) in 5 fractions (3–6 f). The effectiveness of clinical treatment was evaluated by comparing the homogeneity index (HI), conformity index (CI), coverage of the planning target volume (PTV) and dose distribution parameters of organs at risk (OAR). Results All plans met the limits of clinical target dose and OAR. CK-MLC plans had the lowest maximum dose of 2 cm normal tissue from PTV margin (D2cm), indicating a low risk of peripheral radiation damage. Additionally, the CK-MLC plans had the lowest dose parameters and provided the best protection for the kidney, spinal cord, small intestine, and duodenum, with a paired t-test p-value < 0.05, indicating a statistical difference. Conclusion High conformity and adjustability of CK-MLC allowed for precise complex target localization and conformal dose distribution, benefiting tumor treatment while maximally reducing damage to OAR. This study provides valuable dosimetric evidence for SBRT technique selection for pancreatic cancer.

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Assessment of HDR brachytherapy-replicating prostate radiotherapy planning for tomotherapy, cyberknife and VMAT

Cited by 3 publications

References 22 publications

Ultrahypofractionated Radiotherapy versus Conventional to Moderate Hypofractionated Radiotherapy for Clinically Localized Prostate Cancer

Ultrahypofractionated Radiotherapy versus Conventional to Moderate Hypofractionated Radiotherapy for Clinically Localized Prostate Cancer

Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer

Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer

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